Patents by Inventor Anna M. Leech
Anna M. Leech has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11433267Abstract: Doped metal oxide compositions are provided that consist essentially of: fluoride; alumina; and less than 10% H2O. Detoxification reactions are provided that can include a mixture of less than 50% by weight doped metal oxide composition and chemical warfare agent. Cartridges are provided that can include a doped metal oxide composition, the composition including: fluoride and alumina. Methods for detoxifying a chemical warfare agent are also provided. The methods can include exposing the chemical warfare agent to a doped metal oxide composition, wherein the doped metal oxide composition is less than 50% by mass of the chemical warfare agent.Type: GrantFiled: September 23, 2019Date of Patent: September 6, 2022Assignee: TELEDYNE FLIR DETECTION, INC.Inventors: Anna M. Leech, Jeremy P. Walker, Jennifer L. Poole, Robert J. Sovesky
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Patent number: 10808238Abstract: The present invention provides a biomolecule conjugate having one or more functionalized biomolecules wherein the biomolecule is functionalized with one or more reactive sites, and at least one polymer capable of undergoing a polymer growth reaction, wherein the polymer is attached to at least one of the reactive sites of the functionalized biomolecule and wherein the polymer envelopes the functionalized biomolecule to form a reversible nanoparticle structure which protects the biomolecule by dynamically collapsing to preserve the biomolecule when an adverse environmental stimulus is present. A method of protecting a biomolecule from environmental conditions is also provided.Type: GrantFiled: December 23, 2014Date of Patent: October 20, 2020Assignee: FLIR DETECTION, INC.Inventors: Jeremy P. Walker, David C. Wilson, Anna M. Leech, Jessica J. Sinclair
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Patent number: 9452237Abstract: A smart antimicrobial material and dressing to inhibit microbial growth is provided. Endogenous chemicals, such as metabolites produced from bacteria are utilized as chemical substrates and converted by enzymes to produce a disinfecting compound that will in turn inhibit the targeted microorganism. The material shall remain passive until such time as it encounters a microbe which expresses and/or secretes specific metabolites or markers. The enzyme or enzymes embedded in the smart material converts the metabolite into a disinfecting compound, which in turn either kills the microorganism or prevents it from multiplying on the surface of the material.Type: GrantFiled: June 12, 2013Date of Patent: September 27, 2016Assignee: FLIR Detection, Inc.Inventors: Anna M. Leech, Jeremy P. Walker, Scott Donahue, Jermaine D. Johnson, Jessica J. Sinclair
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Publication number: 20150376594Abstract: The present invention provides a biomolecule conjugate having one or more functionalized biomolecules wherein the biomolecule is functionalized with one or more reactive sites, and at least one polymer capable of undergoing a polymer growth reaction, wherein the polymer is attached to at least one of the reactive sites of the functionalized biomolecule and wherein the polymer envelopes the functionalized biomolecule to form a reversible nanoparticle structure which protects the biomolecule by dynamically collapsing to preserve the biomolecule when an adverse environmental stimulus is present. A method of protecting a biomolecule from environmental conditions is also provided.Type: ApplicationFiled: December 23, 2014Publication date: December 31, 2015Inventors: Jeremy P. Walker, David C. Wilson, Anna M. Leech, Jessica J. Sinclair
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Patent number: 9121017Abstract: The present invention provides a thermoresponsive nanoparticle useful for the stabilization of enzymes in environments having a temperature greater than thirty degrees Centigrade. The thermoresponsive nanoparticle has (a) a functionalized enzyme conjugate having one or more enzymes or biological catalysts, the enzymes or biological catalysts are modified with palmitic acid N-hydroxysuccinimide ester and acryclic acid N-hydroxysuccinimide ester, and (b) a thermally responsive polymer, wherein the functionalized enzyme conjugate is encapsulated within the thermally responsive polymer. A nanocatalyst is provided that has one or more proteins. The proteins are covalently immobilized and encapsulated within a thermally responsive polymer shell. The proteins are one or more enzymes or biological catalysts. A method for protecting the proteins is also set forth.Type: GrantFiled: May 7, 2013Date of Patent: September 1, 2015Assignee: FLIR Detection, Inc.Inventors: Jeremy P. Walker, Anna M. Leech
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Publication number: 20150174283Abstract: A smart antimicrobial material and dressing to inhibit microbial growth is provided. Endogenous chemicals, such as metabolites produced from bacteria are utilized as chemical substrates and converted by enzymes to produce a disinfecting compound that will in turn inhibit the targeted microorganism. The material shall remain passive until such time as it encounters a microbe which expresses and/or secretes specific metabolites or markers. The enzyme or enzymes embedded in the smart material converts the metabolite into a disinfecting compound, which in turn either kills the microorganism or prevents it from multiplying on the surface of the material.Type: ApplicationFiled: March 2, 2015Publication date: June 25, 2015Inventors: Anna M. Leech, Jeremy P. Walker, Scott Donahue, Jermaine D. Johnson, Jessica J. Sinclair
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Publication number: 20130344130Abstract: A smart antimicrobial material and dressing to inhibit microbial growth is provided. Endogenous chemicals, such as metabolites produced from bacteria are utilized as chemical substrates and converted by enzymes to produce a disinfecting compound that will in turn inhibit the targeted microorganism. The material shall remain passive until such time as it encounters a microbe which expresses and/or secretes specific metabolites or markers. The enzyme or enzymes embedded in the smart material converts the metabolite into a disinfecting compound, which in turn either kills the microorganism or prevents it from multiplying on the surface of the material.Type: ApplicationFiled: June 12, 2013Publication date: December 26, 2013Inventors: Anna M. Leech, Jeremy P. Walker, Scott Donahue, Jermaine D. Johnson, Jessica J. Sinclair
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Publication number: 20130244301Abstract: The present invention provides a thermoresponsive nanoparticle useful for the stabilization of enzymes in environments having a temperature greater than thirty degrees Centigrade. The thermoresponsive nanoparticle has (a) a functionalized enzyme conjugate having one or more enzymes or biological catalysts, the enzymes or biological catalysts are modified with palmitic acid N-hydroxysuccinimide ester and acryclic acid N-hydroxysuccinimide ester, and (b) a thermally responsive polymer, wherein the functionalized enzyme conjugate is encapsulated within the thermally responsive polymer. A nanocatalyst is provided that has one or more proteins. The proteins are covalently immobilized and encapsulated within a thermally responsive polymer shell. The proteins are one or more enzymes or biological catalysts. A method for protecting the proteins is also set forth.Type: ApplicationFiled: May 7, 2013Publication date: September 19, 2013Inventors: Jeremy P. Walker, Anna M. Leech
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Patent number: 8460907Abstract: The present invention provides a thermoresponsive nanoparticle useful for the stabilization of enzymes in environments having a temperature greater than thirty degrees Centigrade. The thermoresponsive nanoparticle has (a) a functionalized enzyme conjugate having one or more enzymes or biological catalysts, the enzymes or biological catalysts are modified with palmitic acid N-hydroxysuccinimide ester and acrylic acid N-hydroxysuccinimide ester, and (b) a thermally responsive polymer, wherein the functionalized enzyme conjugate is encapsulated within the thermally responsive polymer. A nanocatalyst is provided that has one or more proteins. The proteins are covalently immobilized and encapsulated within a thermally responsive polymer shell. The proteins are one or more enzymes or biological catalysts. A method for protecting the proteins is also set forth.Type: GrantFiled: November 11, 2010Date of Patent: June 11, 2013Assignee: ICx-AgentaseInventors: Jeremy P. Walker, Anna M. Leech
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Patent number: 8017352Abstract: An enzyme based nondestructive sensor for the qualitative detection of spoilage in seafood is provided wherein the sensor does not alter the physical composition of the seafood specimen. The sensor comprises a sampling matrix, at least three or more enzymes in contact with the sampling matrix, and at least one indicator compound in contact with the sampling matrix. The enzymes are capable of interacting with four target chemicals comprising putrescine, cadaverine, histamine and tyramine, which are located on the surface of the seafood specimen. The indicator compound is capable of changing the color of the sampling matrix thereby indicating a qualitative visually detectable color change. A method for the nondestructive detection of the quality of a seafood specimen at any given time and for determining the remaining usable shelf life of the seafood specimen is disclosed.Type: GrantFiled: June 9, 2009Date of Patent: September 13, 2011Assignee: Agentase, LLCInventors: Anna M. Leech, Jessica L. Palumbo, Jason A. Berberich, Keith E. LeJeune
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Publication number: 20110117623Abstract: The present invention provides a thermoresponsive nanoparticle useful for the stabilization of enzymes in environments having a temperature greater than thirty degrees Centigrade. The thermoresponsive nanoparticle has (a) a functionalized enzyme conjugate having one or more enzymes or biological catalysts, the enzymes or biological catalysts are modified with palmitic acid N-hydroxysuccinimide ester and acryclic acid N-hydroxysuccinimide ester, and (b) a thermally responsive polymer, wherein the functionalized enzyme conjugate is encapsulated within the thermally responsive polymer. A nanocatalyst is provided that has one or more proteins. The proteins are covalently immobilized and encapsulated within a thermally responsive polymer shell. The proteins are one or more enzymes or biological catalysts. A method for protecting the proteins is also set forth.Type: ApplicationFiled: November 11, 2010Publication date: May 19, 2011Inventors: Jeremy P. Walker, Anna M. Leech
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Publication number: 20100028927Abstract: An enzyme based nondestructive sensor for the qualitative detection of spoilage in seafood is provided wherein the sensor does not alter the physical composition of the seafood specimen. The sensor comprises a sampling matrix, at least three or more enzymes in contact with the sampling matrix, and at least one indicator compound in contact with the sampling matrix. The enzymes are capable of interacting with four target chemicals comprising putrescine, cadaverine, histamine and tyramine, which are located on the surface of the seafood specimen. The indicator compound is capable of changing the color of the sampling matrix thereby indicating a qualitative visually detectable color change. A method for the nondestructive detection of the quality of a seafood specimen at any given time and for determining the remaining usable shelf life of the seafood specimen is disclosed.Type: ApplicationFiled: June 9, 2009Publication date: February 4, 2010Applicant: Agentase, LLCInventors: Anna M. Leech, Jessica L. Palumbo, Jason A. Berberich, Keith E. LeJeune
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Patent number: 7560271Abstract: An enzyme based nondestructive sensor for the qualitative detection of spoilage in seafood is provided wherein the sensor does not alter the physical composition of the seafood specimen. The sensor comprises a sampling matrix, at least three or more enzymes in contact with the sampling matrix, and at least one indicator compound in contact with the sampling matrix. The enzymes are capable of interacting with four target chemicals comprising putrescine, cadaverine, histamine and tyramine, which are located on the surface of the seafood specimen. The indicator compound is capable of changing the color of the sampling matrix thereby indicating a qualitative visually detectable color change. A method for the nondestructive detection of the quality of a seafood specimen at any given time and for determining the remaining usable shelf life of the seafood specimen is disclosed.Type: GrantFiled: December 20, 2006Date of Patent: July 14, 2009Assignee: Agentase, LLCInventors: Anna M. Leech, Jessica L. Palumbo, Jason A. Berberich, Keith E. LeJeune
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Publication number: 20080153079Abstract: An enzyme based nondestructive sensor for the qualitative detection of spoilage in seafood is provided wherein the sensor does not alter the physical composition of the seafood specimen. The sensor comprises a sampling matrix, at least three or more enzymes in contact with the sampling matrix, and at least one indicator compound in contact with the sampling matrix. The enzymes are capable of interacting with four target chemicals comprising putrescine, cadaverine, histamine and tyramine, which are located on the surface of the seafood specimen. The indicator compound is capable of changing the color of the sampling matrix thereby indicating a qualitative visually detectable color change. A method for the nondestructive detection of the quality of a seafood specimen at any given time and for determining the remaining usable shelf life of the seafood specimen is disclosed.Type: ApplicationFiled: December 20, 2006Publication date: June 26, 2008Inventors: Anna M. Leech, Jessica L. Palumbo, Jason A. Berberich, Keith E. LeJeune