Patents by Inventor Anna M. Wobus

Anna M. Wobus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Embryonal cardiac muscle cells, their preparation and their use
    Patent number: 5928943
    Abstract: The invention concerns embryonal (cardiomyocytary and cardiomyoblastary) cardiac muscle cells, their preparation and their use, in particular for cell-mediated gene transplant. The areas of application of the invention are medicine and genetic engineering. The embryonal cardiac muscle cells according to the invention contain two gene constructs comprising: a) a regulatory, 1.2-kb long DNA sequence of the ventricle-specific myosin light-chain-2 (MLC-2v) promoter, the selectable marker gene .beta.-galactosidase in fusion with the reporter gene neomycin; and b) a regulatory DNA sequence of the herpes simplex virus thymidine kinase promoter and the selectable marker gene hygromycin, and optionally immortalizing genes and/or optionally genes inactivated by homologous recombination and/or optionally one or a plurality of therapeutic genes.
    Type: Grant
    Filed: August 22, 1997
    Date of Patent: July 27, 1999
    Assignee: Institut fur Pflanzengenetik und Kulturpflanzenforschung
    Inventors: Wolfgang-Michael Franz, Anna M. Wobus