Abstract: Provided are compositions and methods of treating impaired glucose tolerance which substantially increase the islet donor pool and safety as well as remove the need for anti-rejections drugs. Described are methods of making cell clusters comprising: expanding pancreatic islet cells; and forming cell clusters comprising: the expanded islet cells and mesenchymal/adipose stem cells. Expansion of the islet cells may include=>five population doublings. The islet cells may be primary islet cells obtained from an adult, non-diabetic donor having a North America Islet Donor Score (NAIDS) of <80. Described are cell clusters produced by the methods.

Abstract: The present disclosure relates to compositions for the treatment of microvascular diseases. Such compositions may comprise mesenchymal and/or adipose stem cells; and/or exosomes isolated from mesenchymal and/or adipose stem cells. Further included are methods of treating microvascular disease using the compositions and methods of making the compositions.