Patents by Inventor Anna Maria Cornelia Francisca Castelijns
Anna Maria Cornelia Francisca Castelijns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10221124Abstract: The present invention relates to a process for the preparation of diaminobutane from ornithine, comprising steps of: i. preparing a solution of (a) a salt of ornithine and an acid; and (b) an aldehyde or a ketone, or a mixture thereof; in (c) a solvent, wherein the solvent comprises a protic organic solvent or a dipolar aprotic organic solvent, or a mixture thereof and ii. heating the solution to a temperature above 100° C., thereby inducing decarboxylation of the ornithine and formation of diaminobutane.Type: GrantFiled: March 15, 2016Date of Patent: March 5, 2019Assignee: DSM IP ASSETS B.V.Inventors: Rinke Marcel Altink, Anna Maria Cornelia Francisca Castelijns
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Publication number: 20180050981Abstract: The present invention relates to a process for the preparation of diaminobutane from ornithine, comprising steps of: i. preparing a solution of (a) a salt of ornithine and an acid; and (b) an aldehyde or a ketone, or a mixture thereof; in (c) a solvent, wherein the solvent comprises a protic organic solvent or a dipolar aprotic organic solvent, or a mixture thereof and ii. heating the solution to a temperature above 100° C., thereby inducing decarboxylation of the ornithine and formation of diaminobutane.Type: ApplicationFiled: March 15, 2016Publication date: February 22, 2018Inventors: Rinke Marcel ALTINK, Anna Maria Cornelia Francisca CASTELIJNS
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Patent number: 9334224Abstract: This invention relates to a process for the preparation of alkenoic acid esters comprising contacting a lactone with an alcohol and an acidic catalyst in the gas phase, characterized in that the process is carried out in the presence of at least 0.26 wt. % water, relative to the amount of the lactone. The process may result in a good production yield and selectivity with respect to the production of alkenoic acid esters and may also result in less formation of dialkylethers. The improved yield advantageously allows energy conservation.Type: GrantFiled: September 21, 2012Date of Patent: May 10, 2016Assignee: DSM IP ASSETS B.V.Inventor: Anna Maria Cornelia Francisca Castelijns
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Patent number: 9328052Abstract: This invention relates to a process for the preparation of alkenoic acid esters comprising contacting a lactone with an alcohol and an acidic heterogeneous catalyst, characterized in that the process is carried out in the presence of at least 20 ppm of an acid having a pKa of 5 or less, relative to the amount of the lactone. The presence of at least 20 ppm of an acid having a pKa of 5 or less may stabilize the catalyst during the reaction and may also be used for reactivating an acidic heterogeneous catalyst. The improved yield advantageously allows energy conservation.Type: GrantFiled: December 20, 2012Date of Patent: May 3, 2016Assignee: DSM IP ASSETS B.V.Inventor: Anna Maria Cornelia Francisca Castelijns
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Patent number: 8680316Abstract: The present invention relates to a novel process for the preparation of cis-1-ammonium-4-alkoxycyclohexanecarbonitrile salts and to novel intermediates or starting compounds which are passed through or used in the process according to the invention.Type: GrantFiled: December 19, 2011Date of Patent: March 25, 2014Assignee: Bayer CropScience AGInventors: Frank Volz, Albert Schnatterer, Bernardus Kaptein, Anna Maria Cornelia Francisca Castelijns
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Patent number: 8598303Abstract: The invention provides a process for the preparation of valerolactone, said process comprising reacting levulinic acid with hydrogen by using a solid Ru catalyst, characterized in that the process is carried out in the presence of at least 0.08% (w/w) water relative to the amount of levulinic acid. Said process may be faster and more selective. This process advantageously allows the production of valerolactone from renewable sources. The valerolactone may be used in the preparation of methylpentenoate, adipic acid dimethylester, adipic acid, hexamethylenediamine, and polyamide 6,6 (all claimed).Type: GrantFiled: June 20, 2012Date of Patent: December 3, 2013Assignee: DSM IP Assets B.V.Inventors: Anna Maria Cornelia Francisca Castelijns, Michele Catherine Christianne Janssen, Henricus Wilhemus Leonardus Marie Vaessen
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Publication number: 20130310577Abstract: Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R4 being a branched C3-6 alkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10).Type: ApplicationFiled: July 11, 2013Publication date: November 21, 2013Applicant: DSM IP ASSETS B.V.Inventors: Ben DE LANGE, Anna Maria Cornelia Francisca CASTELIJNS, Johannes Gerardus DE VRIES, Andreas Hendrikus Maria DE VRIES, Jeroen Antonius Franciscus BOOGERS
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Patent number: 8563279Abstract: Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R4 being a branched C3—6 alkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10).Type: GrantFiled: December 19, 2008Date of Patent: October 22, 2013Assignee: DSM IP Assets B.V.Inventors: Ben De Lange, Anna Maria Cornelia Francisca Castelijns, Johannes Gerardus De Vries, Andreas Hendrikus Maria De Vries, Jeroen Antonius Franciscus Boogers, Quirinus Bernardus Broxterman
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Publication number: 20120329981Abstract: The invention provides a process for the preparation of valerolactone, said process comprising reacting levulinic acid with hydrogen by using a solid Ru catalyst, characterised in that the process is carried out in the presence of at least 0.08% (w/w) water relative to the amount of levulinic acid. Said process may be faster and more selective. This process advantageously allows the production of valerolactone from renewable sources. The valerolactone may be used in the preparation of methylpentenoate, adipic acid dimethylester, adipic acid, hexamethylenediamine, and polyamide 6,6 (all claimed).Type: ApplicationFiled: June 20, 2012Publication date: December 27, 2012Applicant: DSM IP ASSETS B.V.Inventors: Anna Maria Cornelia Francisca Castelijns, Michele Catherine Christianne Janssen, Henricus Wilhemus Leonardus Marie Vaessen
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Publication number: 20120197035Abstract: The present invention relates to a novel process for the preparation of cis-1-ammonium-4-alkoxycyclohexanecarbonitrile salts and to novel intermediates or starting compounds which are passed through or used in the process according to the invention.Type: ApplicationFiled: December 19, 2011Publication date: August 2, 2012Applicant: Bayer CropScience AGInventors: Frank Volz, Albert Schnatterer, Bernardus Kaptein, Anna Maria Cornelia Francisca Castelijns
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Patent number: 8088955Abstract: This invention relates to novel alpha-substituted ?,?-unsaturated E- or Z-aldehydes, or isomer mixture thereof, of the formula (I) in which R1 and R2 may be identical or different and are each H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms and R3 and R4 may be identical or different and are each a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, and R5 may be identical or different and is H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, to the use thereof, and to processes for their preparation. The invention further relates to the preparation of further intermediates for pharmaceuticals and to the preparation of the pharmaceuticals.Type: GrantFiled: July 11, 2008Date of Patent: January 3, 2012Assignee: DSM Fine Chemicals Austria NFG GmbH & Co. KGInventors: Gerhard Steinbauer, Martina Kotthaus, Klaus Edegger, Stefaan Marie Andre De Wildeman, Henricus Martinus Maria Gerardus Straatman, Anna Maria Cornelia Francisca Castelijns, Andreas Hendrikus Maria De Vries
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Publication number: 20110301365Abstract: This invention relates to novel alpha-substituted ?,?-unsaturated E- or Z-aldehydes, or isomer mixture thereof, of the formula in which R1 and R2 may be identical or different and are each H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms and R3 and R4 may be identical or different and are each a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, and R5 may be identical or different and is H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, to the use thereof, and to processes for their preparation. The invention further relates to the preparation of further intermediates for pharmaceuticals and to the preparation of the pharmaceuticals.Type: ApplicationFiled: August 8, 2011Publication date: December 8, 2011Applicant: DSM IP Assets B.V.Inventors: Gerhard STEINBAUER, Martina Kotthaus, Klaus Edegger, Stefaan Marie Andre De Wildeman, Henricus Martinus Maria Gerardus Straatman, Anna Maria Cornelia Francisca Castelijns, Andreas Hendrikus Maria De Vries
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Publication number: 20110251397Abstract: The present invention relates to a method for the preparation of 3-methylpyridin by reacting 2-methyl-2,5-di-aminopentane and/or 3-methylpiperidin at about atmospheric pressure and a temperature of 180° C. to 400° C. in a hydrogen atmosphere free of oxygen gas in the presence of a suitable catalyst and of water and/or a volatile alcohol.Type: ApplicationFiled: September 8, 2009Publication date: October 13, 2011Inventors: Anna Maria Cornelia Francisca Castelijns, Pierre Louis Woestenborghs, Henricus Wilhelmus Leonardus Marie Vaessen
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Publication number: 20110244531Abstract: The invention relates to a process for the preparation of compounds that are important building blocks in convergent synthesis routes to 2(S),4(S),5(S),7(S)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amides or pharmaceutically acceptable salts thereof, such as the compound Aliskiren, and to a process for the preparation of these octanoyl amides, comprising reacting said building block.Type: ApplicationFiled: July 23, 2009Publication date: October 6, 2011Inventors: Andreas Hendrikus Maria De Vries, Gerardus Karel Maria Verzijl, Petrus Johannes Hermsen, Anna Maria Cornelia Francisca Castelijns
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Publication number: 20110008852Abstract: Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R4 being a branched C3—6 alkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10).Type: ApplicationFiled: December 19, 2008Publication date: January 13, 2011Inventors: Ben De Lange, Anna Maria Cornelia Francisca Castelijns, Johannes Gerardus De Vries, Andreas Hendrikus Maria De Vries, Jeroen Antonius Boogers, Quirinus Bernardus Broxterman
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Patent number: 6603043Abstract: Process for the preparation of a Schiff base of an &agr;-alkyl-&agr;-amino acid amide and an aldehyde, wherein the corresponding &agr;-aminonitrile is contacted with a base and the aldehyde and wherein it is ensured that the reagents are in good contact. The Schiff base obtained may be further hydrolysed to form the &agr;-alkyl-&agr;-amino acid amide and the aldehyde. Preferably a substituted or unsubstituted benzaldehyde is used as the aldehyde. The reaction is preferably carried out in a practically homogeneously mixed phase obtained by using a solvent, for example methanol or ethanol. Preferably NaOH or KOH is used as the base.Type: GrantFiled: July 13, 2001Date of Patent: August 5, 2003Assignee: DSM N.V.Inventors: Dominique Monique Charles Callant, Daniel Mink, Anna Maria Cornelia Francisca Castelijns
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Publication number: 20020072634Abstract: Process for the preparation of a Schiff base of an &agr;-alkyl-&agr;-amino acid amide and an aldehyde, wherein the corresponding &agr;-aminonitrile is contacted with a base and the aldehyde and wherein it is ensured that the reagents are in good contact. The Schiff base obtained may be further hydrolysed to form the &agr;-alkyl-&agr;-amino acid amide and the aldehyde.Type: ApplicationFiled: July 13, 2001Publication date: June 13, 2002Inventors: Dominique Monique Charles Callant, Daniel Mink, Anna Maria Cornelia Francisca Castelijns