Patents by Inventor Anna-Maria Hays

Anna-Maria Hays has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220033518
    Abstract: This invention relates to prostate-specific membrane antigen (PSMA) antibodies and antibody drug conjugates comprising at least one non-naturally-encoded amino acid. Disclosed herein are ?PSMA antibodies with one or more non-naturally encoded amino acids and further disclosed are antibody drug conjugates wherein the ?PSMA antibodies of the invention are conjugated to one or more toxins. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid antibody drug conjugates, dolastatin analogs, and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Application
    Filed: August 26, 2020
    Publication date: February 3, 2022
    Applicant: Ambrx,Inc.
    Inventors: Richard Barnett, Feng Tian, Anna-Maria A. Hays Putnam, Marco Gymnopoulos, Nickolas Knudsen, Andrew Beck, Ying Sun
  • Publication number: 20210261637
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Application
    Filed: February 2, 2021
    Publication date: August 26, 2021
    Inventors: Thomas P. CUJEC, Roberto MARIANI, Anna-Maria A. HAYS PUTNAM, William M. KEEFE, Nick KNUDSEN, Lillian SKIDMORE, Jason PINKSTAFF, Vadim KRAYNOV
  • Patent number: 10961291
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: March 30, 2021
    Assignee: AMBRX, INC.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Skidmore, Jason Pinkstaff, Vadim Kraynov
  • Patent number: 10800856
    Abstract: This invention relates to prostate-specific membrane antigen (PSMA) antibodies and antibody drug conjugates comprising at least one non-naturally-encoded amino acid. Disclosed herein are ?PSMA antibodies with one or more non-naturally encoded amino acids and further disclosed are antibody drug conjugates wherein the ?PSMA antibodies of the invention are conjugated to one or more toxins. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid antibody drug conjugates, dolastatin analogs, and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: October 13, 2020
    Assignee: Ambrx, Inc.
    Inventors: Richard S. Barnett, Feng Tian, Anna-Maria A. Hays Putnam, Marco Gymnopoulos, Nick Knudsen, Andrew Beck, Ying Sun
  • Publication number: 20200031894
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Application
    Filed: June 17, 2019
    Publication date: January 30, 2020
    Inventors: Thomas P. CUJEC, Roberto MARIANI, Anna-Maria A. HAYS PUTNAM, William M. KEEFE, Nick KNUDSEN, Lillian SKIDMORE, Jason PINKSTAFF, Vadim KRAYNOV
  • Patent number: 10377805
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: August 13, 2019
    Assignee: AMBRX, INC.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Skidmore, Jason Pinkstaff, Vadim Kraynov
  • Publication number: 20190071482
    Abstract: Modified bovine G-CSF polypeptides and uses thereof are provided.
    Type: Application
    Filed: October 19, 2018
    Publication date: March 7, 2019
    Inventors: Anna-Maria A. HAYS PUTNAM, Nick KNUDSEN, Thea NORMAN, Alan KODER, Vadim KRAYNOV, Lillian HO, Peter C. CANNING
  • Patent number: 10138283
    Abstract: Modified bovine G-CSF polypeptides and uses thereof are provided.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: November 27, 2018
    Assignees: AMBRX, INC., ELANCO US INC.
    Inventors: Anna-Maria A. Hays Putnam, Nick Knudsen, Thea Norman, Alan Koder, Vadim Kraynov, Lillian Ho, Peter C. Canning
  • Publication number: 20180298073
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Application
    Filed: April 13, 2018
    Publication date: October 18, 2018
    Inventors: Thomas P. CUJEC, Roberto MARIANI, Anna-Maria A. HAYS PUTNAM, William M. KEEFE, Nick KNUDSEN, Lillian SKIDMORE, Jason PINKSTAFF, Vadim KRAYNOV
  • Patent number: 9975936
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: May 22, 2018
    Assignee: AMBRX, INC.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Skidmore, Jason Pinkstaff, Vadim Kraynov
  • Patent number: 9938333
    Abstract: Modified human leptin polypeptides and uses thereof are provided.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: April 10, 2018
    Assignee: Ambrx, Inc.
    Inventors: Vadim Kraynov, Anna-Maria A. Hays Putnam, Nick Knudsen, Jason Pinkstaff, Heather Myler, Lorraine Sullivan
  • Patent number: 9644014
    Abstract: Modified animal erythropoietin polypeptides and uses thereof are provided.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: May 9, 2017
    Assignees: Ambrx, Inc., Eli Lilly and Company
    Inventors: Feng Tian, Anna-Maria A. Hays Putnam, Frank Song, Stephanie Chu, Joseph Sheffer, Richard S. Barnett, Marc Siladi, Kyle Atkinson, Darin Lee, Peter C. Canning
  • Publication number: 20170096463
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Application
    Filed: October 13, 2016
    Publication date: April 6, 2017
    Inventors: Thomas P. CUJEC, Roberto Mariani, Anna-Maria A. Hays Putnam, Wiliam M. Keefe, Nick Knudsen, Lillian Skidmore, Jason Pinkstaff, Vadim Kraynov
  • Patent number: 9517273
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: December 13, 2016
    Assignee: AMBRX, INC.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, Wiliam M. Keefe, Nick Knudsen, Lillian Skidmore, Jason Pinkstaff, Vadim Kraynov
  • Patent number: 9488660
    Abstract: Disclosed herein are methods of detecting non-natural amino acids and polypeptides that include at least one non-natural amino acid. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of functionalities, including but not limited to oxime, carbonyl, and/or hydroxylamine groups. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, and methods for detecting such polypeptides.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: November 8, 2016
    Assignee: AMBRX, INC.
    Inventors: Zhenwei Miao, Feng Tian, Anna-Maria A. Hays Putnam, Ying Buechler
  • Patent number: 9260472
    Abstract: Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: February 16, 2016
    Assignee: AMBRX, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Richard D. Dimarchi, Anna-Maria A. Hays, Troy E. Wilson, Bee-Cheng Sim, David C. Litzinger
  • Publication number: 20160024166
    Abstract: Modified animal erythropoietin polypeptides and uses thereof are provided.
    Type: Application
    Filed: September 15, 2015
    Publication date: January 28, 2016
    Inventors: Feng TIAN, Anna-Maria A. HAYS PUTNAM, Frank SONG, Stephanie CHU, Joseph SHEFFER, Richard S. BARNETT, Marc SILADI, Kyle ATKINSON, Darin LEE, Peter C. CANNING
  • Patent number: 9175083
    Abstract: Novel antigen-binding polypeptides (ABP) and uses thereof are provided.
    Type: Grant
    Filed: October 16, 2007
    Date of Patent: November 3, 2015
    Assignee: AMBRX, INC.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Troy E. Wilson, Thomas P. Cujec, Feng Tian, Anna-Maria A. Hays, Bruce E. Kimmel, Lillian Ho
  • Publication number: 20150299288
    Abstract: Modified insulin polypeptides and their uses thereof are provided
    Type: Application
    Filed: December 19, 2014
    Publication date: October 22, 2015
    Applicant: AMBRX, INC.
    Inventors: Zhenwei MIAO, Denise KRAWITZ, Vadim KRAYNOV, Tian FENG, Bee-Cheng SIM, Lillian SKIDMORE, Anna-Maria A. HAYS PUTNAM, Nick KNUDSEN, Michael DEGUZMAN
  • Patent number: 9156899
    Abstract: Modified animal erythropoietin polypeptides and uses thereof are provided.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: October 13, 2015
    Assignees: ELI LILLY AND COMPANY, AMBRX, INC.
    Inventors: Feng Tian, Anna-Maria A. Hays Putnam, Frank Song, Stephanie Chu, Joseph Sheffer, Richard S. Barnett, Marc Siladi, Kyle Atkinson, Darin Lee, Peter C. Canning