Patents by Inventor Anna Moshnikova

Anna Moshnikova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • pHLIP® peptide mediated epitope tethering at cell surfaces
    Publication number: 20240066096
    Abstract: The invention features methods and compositions for eliciting an anti-tumor response in a subject comprising administering to the subject a pHLIP? construct comprising an antibody recruiting molecule linked to one or more pHLIP? peptides by a non-cleavable linker compound. The construct increases the amount of the antibody recruiting molecule on the surface of a diseased cell.
    Type: Application
    Filed: May 30, 2023
    Publication date: February 29, 2024
    Inventors: Yana K. RESHETNYAK, Oleg A. ANDREEV, Anna MOSHNIKOVA, Donald M. Engelman
  • PHLIP®-MEDIATED INTRACELLULAR DELIVERY OF IMMUNO-STIMULATORY COMPOUNDS
    Publication number: 20220088208
    Abstract: The invention features a composition comprising an immuno-stimulatory compound and a pHLIP® peptide, e.g., an immunostimulatory compound that comprises a cyclic purine dinucleotide, which binds to a stimulator of interferon genes (STING) such as a cGAMP cyclic compound inside a cell.
    Type: Application
    Filed: January 28, 2020
    Publication date: March 24, 2022
    Applicants: University of Rhode Island Board of Trustees, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman, Anna Moshnikova, John Deacon
  • Carbohydrate tethering at cell surfaces to induce immune response
    Patent number: 11267853
    Abstract: The invention features a compositions and methods for inducing an immune response to targeted cells. The compositions induce targeting of a cell by positioning carbohydrate epitopes on the surface of the cell by conjugation of the epitope to a pH-triggered membrane peptide (pHLIP®).
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: March 8, 2022
    Assignees: University of Rhode Island Board of Trustees, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Anna Moshnikova, Donald M. Engelman
  • PHLIP®-MEDIATED TARGETING OF CORTICOSTEROIDS TO DISEASED TISSUE
    Publication number: 20200323882
    Abstract: The invention features a composition comprising a corticosteroid and a pHLIP® peptide. pHLIP® peptides target corticosteroids to cell surface acidity in inflamed and fibrotic tissues, where they translocate corticosteroids across plasma membranes into the cytoplasms of cells, thereby suppressing inflammation in the targeted tissues while avoiding the side effects resulting from non-targeted administration.
    Type: Application
    Filed: March 13, 2020
    Publication date: October 15, 2020
    Inventors: Yana K. Reshetnyak, David Wolfsohn, Anna Moshnikova, Oleg A. Andreev, Donald M. Engelman
  • pHLIP-Mediated Carbohydrate Tethering at Cell Surfaces to Induce Immune Response
    Publication number: 20200262881
    Abstract: The invention features a compositions and methods for inducing an immune response to targeted cells. The compositions induce targeting of a cell by positioning carbohydrate epitopes on the surface of the cell by conjugation of the epitope to a pH-triggered membrane peptide (pHLIP®).
    Type: Application
    Filed: January 28, 2020
    Publication date: August 20, 2020
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Anna Moshnikova, Donald M. Engelman
  • pHLIP® peptide-mediated epitope tethering at cell surfaces
    Publication number: 20200246420
    Abstract: The invention features methods and compositions for eliciting an anti-tumor response in a subject comprising administering to the subject a pHLIP® construct comprising an antibody recruiting molecule linked to one or more pHLIP® peptides by a non-cleavable linker compound. The construct increases the amount of the antibody recruiting molecule on the surface of a diseased cell.
    Type: Application
    Filed: January 28, 2020
    Publication date: August 6, 2020
    Applicants: Rhode Island Council on Postsecondary Education, Yale University, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Anna Moshnikova, Donald M. Engelman
  • pHLIP® targeted delivery of potent cytotoxic compounds
    Publication number: 20200237926
    Abstract: The invention features a composition comprising a potent cytotoxic compound and a pHLIP® peptide, where, e.g., the cytotoxic compound cannot be used alone due to a lack of targeting. pHLIP® peptide targets cytotoxic compounds to acidic diseased tissue, translocates cytotoxic compounds across plasma membranes into the cytosols of cells in acidic diseased tissues and induces cell death predominantly in the targeted acidic diseased tissue.
    Type: Application
    Filed: January 28, 2020
    Publication date: July 30, 2020
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Anna Moshnikova, Donald M. Engelman