Patents by Inventor Anna Nowak

Anna Nowak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regulatory T cell expressing a chimeric antigen receptor
    Patent number: 12178872
    Abstract: The present invention provides a regulatory T (Treg) cell expressing an antigen chimeric receptor (CAR) comprising a) at least one antigen binding domain, b) a transmembrane domain, and c) a cytoplasmic signaling domain comprising at least one primary cytoplasmic signaling domain and at least the co-stimulatory signaling domain of CD137, wherein said antigen binding domain specifically binds an antigen that is expressed on the surface of a target cell or a tag of a tagged polypeptide that binds to an antigen expressed on the surface of a target cell or a soluble antigen. Compositions comprising said Treg cells, and methods of enrichment and analysis of activated Tregs that express said CAR are also disclosed.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: December 31, 2024
    Assignees: Miltenyi Biotec B.V. & Co. KG, Charité—Universitätsmedizin Berlin
    Inventors: Anna Nowak, Dominik Lock, Andrew Kaiser, Alexander Scheffold
  • Regulatory T Cell Expressing a Chimeric Antigen Receptor
    Publication number: 20200353004
    Abstract: The present invention provides a regulatory T (Treg) cell expressing an antigen chimeric receptor (CAR) comprising a) at least one antigen binding domain, b) a transmembrane domain, and c) a cytoplasmic signaling domain comprising at least one primary cytoplasmic signaling domain and at least the co-stimulatory signaling domain of CD137, wherein said antigen binding domain specifically binds an antigen that is expressed on the surface of a target cell or a tag of a tagged polypeptide that binds to an antigen expressed on the surface of a target cell or a soluble antigen. Compositions comprising said Treg cells, and methods of enrichment and analysis of activated Tregs that express said CAR are also disclosed.
    Type: Application
    Filed: January 17, 2019
    Publication date: November 12, 2020
    Inventors: Anna Nowak, Dominik Lock, Andrew Kaiser, Alexander Scheffold