Patents by Inventor Anna SantaMaria

Anna SantaMaria has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hinokitiol analogues, methods of preparing and pharmaceutical compositions thereof
    Patent number: 12084411
    Abstract: Disclosed are analogues of hinokitiol, methods for preparing them, and pharmaceutical compositions thereof. Also disclosed are methods for their use in treating iron-related diseases.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: September 10, 2024
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, Anthony S. Grillo, Alexander G. Cioffi, Anna SantaMaria, Daniel Blair, Andrew Blake
  • Hybrid Amphotericin B derivatives with reduced toxicity
    Patent number: 11198705
    Abstract: Disclosed are derivatives of amphotericin B (AmB) characterized by improved clinical efficacy with reduced toxicity compared to AmB. Also disclosed are pharmaceutical compositions comprising the AmB derivatives, therapeutic methods of using the AmB derivatives and methods of making the AmB derivatives.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: December 14, 2021
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, Anuj Khandelwal, Jiabao Zhang, Anna SantaMaria
  • HINOKITIOL ANALOGUES, METHODS OF PREPARING AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20210163393
    Abstract: Disclosed are analogues of hinokitiol, methods for preparing them, and pharmaceutical compositions thereof. Also disclosed are methods for their use in treating iron-related diseases.
    Type: Application
    Filed: April 12, 2019
    Publication date: June 3, 2021
    Inventors: Martin D. Burke, Anthony S. Grillo, Alexander G. Cioffi, Anna SantaMaria, Daniel Blair, Andrew Blake
  • RESTORATION OF TRANSMEMBRANE COPPER TRANSPORT
    Publication number: 20210030725
    Abstract: Disclosed are methods of treating a disease or condition characterized by a deficiency of or a defect in a copper transporter using a small molecule. For example, the method may increase copper transport, or it may increase copper release. Additionally, the small molecule may be hinokitiol, or it may be selected from the group consisting of amphotericin B, calcimycin, nonactin, deferiprone, purpurogallin, and maltol. Also provided is a method of identifying a small molecule capable of treating a disease or condition characterized by a deficiency of or a defect in a copper transporter.
    Type: Application
    Filed: March 27, 2019
    Publication date: February 4, 2021
    Inventors: Martin D. Burke, Chritopher Nardone, Anddrew Blake, Anna SantaMaria, Anthony S. Grillo, Alexander G. Cioffi, Yinghuan Lyu
  • HYBRID AMPHOTERICIN B DERIVATIVES WITH REDUCED TOXICITY
    Publication number: 20200079811
    Abstract: Disclosed are derivatives of amphotericin B (AmB) characterized by improved clinical efficacy with reduced toxicity compared to AmB. Also disclosed are pharmaceutical compositions comprising the AmB derivatives, therapeutic methods of using the AmB derivatives and methods of making the AmB derivatives.
    Type: Application
    Filed: September 6, 2019
    Publication date: March 12, 2020
    Inventors: Martin D. Burke, Anuj Khandelwal, Jiabao Zhang, Anna SantaMaria