Abstract: Composition and methods for treating Niemann-Pick disease type C are disclosed, utilizing lipid nanoparticles (LNPs) encapsulating mRNA sequences coding for NPC1 and/or NPC2 proteins.

Abstract: The present invention relates to compositions comprising nanoparticles associated with or without one or more tolerogenic antigens, and compositions comprising an immunomodulatory agent (e.g., interleukin-2 (IL-2) or an IL-2 variant or an IL-2/IC)), and related methods involving co-administration of such compositions for purposes of inducing amplification of regulatory T cells (Tregs) (e.g., antigen-specific regulatory Tregs). The present invention further provides methods of treating autoimmune disorders through administering to a subject a composition comprising nanoparticles associated with or without one or more tolerogenic antigens associated with the autoimmune disorder prior to administering to the subject a composition comprising an immunomodulatory agent.

Abstract: Accordingly, the present invention relates compositions comprising synthetic HDL (sHDL) nanoparticles, methods for synthesizing such sHDL nanoparticles, as well as systems and methods utilizing such sHDL nanoparticles (e.g., in diagnostic and/or therapeutic settings). In particular, the present invention provides compositions comprising sHDL nanoparticles for purposes of preventing, attenuating, and/or treating sepsis and sepsis related disorders in a subject, conditions and symptoms caused by a viral infection (e.g., COVID-19)) in a subject, and conditions and symptoms caused by thrombosis in a subject.

Abstract: The present invention relates to nanoparticles complexed with N-2-benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]-benzenesulfonamide (ML355) configured for treating cardiovascular related disorders. In particular, the present invention is directed to compositions comprising synthetic HDL (sHDL) nanoparticles carrying ML355 configured for treating cardiovascular related disorders (e.g., inhibit platelet aggregation; inhibit thrombosis formation; inhibit vessel occlusion; inhibit platelet associated 12-LOX activity, as well as systems and methods utilizing such sHDL nanoparticles (e.g., therapeutic settings).

Abstract: Provided herein are compositions and methods for the treatment of diseases, such as hyperproliferative diseases, employing compounds formulated for pharmaceutical and research use via nanoparticles.

Abstract: Provided herein are compositions and methods for the treatment of diseases, such as hyperproliferative diseases, employing compounds formulated for pharmaceutical and research use via nanoparticles.

Abstract: The present invention relates to peptide-phospholipid formulations, methods of generating these formulations and methods of administering these formulations for treatment. The present disclosure also provides methods for increasing cholesterol efflux, inducing anti-atherosclerotic activity, increasing pre-? HDL, inducing anti-inflammatory activity, inhibiting cytokine release (including cytokines TNF-?, IL-1?, and/or IL-6 or a combination thereof) and increasing cholesterol mobilization and/or esterification by administering the peptide-phospholipid formulations disclosed.