Patents by Inventor Anna Tampieri
Anna Tampieri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11628602Abstract: Filter made entirely with natural and biodegradable materials, for the protection of the respiratory tract of patients in the medical-surgical field and process for making it. The filter has a porosity or 80-98% and pore diameters of 100-350 micrometers and the pores have a shape of channels open at the ends, which are parallel to each other. The filter is obtained by preparing an aqueous solution of chitosan and an aqueous solution of gelatin, mixing them, pouring it into a container, keeping the container closed until obtaining a hydrogel and freeze-drying. A cross-linking step takes place by (a) adding a chemical cross-linker to the mixture of the chitosan and gelatine solutions and cross-linking before freeze-drying, or (b) subjecting the freeze-drying product to a thermal dehydration treatment.Type: GrantFiled: February 27, 2018Date of Patent: April 18, 2023Assignee: CONSIGLIO NAZIONALE DELLE RICERCHEInventors: Monica Sandri, Anna Tampieri, Simone Sprio
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Stabilized amorphous calcium phosphate doped with fluoride ions and a process for producing the same
Patent number: 11377353Abstract: The invention relates to a process for the preparation of a citrate-coated amorphous calcium phosphate nanoparticle which comprises the following steps: 1) providing a first solution of a salt of calcium and a citrate salt wherein the molar ratio of citrate ion to calcium ion is in the range from 1 to 2 thus obtaining a clear first solution; 2) providing a second solution of a salt capable to give phosphate anion and a carbonate salt; 3) mixing together the first and the second solution at a pH in the range from 8 to 11; 4) precipitating the nanoparticle; and 5) drying the nanoparticle obtained from step 4). Preferably and advantageously the invention provides for the addition of a fluoride compound in step 2) for obtaining a fluorine-doped citrate-coated calcium phosphate nanoparticle or a nanoparticle agglomerate. The nanoparticle/nanoparticle agglomerate of the invention has a peculiar superficial area and a diameter that allow to use it as a biomaterial for dentistry application.Type: GrantFiled: June 27, 2019Date of Patent: July 5, 2022Assignee: CURASEPT A.D.S. S.R.L.Inventors: Michele Iafisco, Anna Tampieri -
Patent number: 11357886Abstract: The present disclosure relates to a hydroxyapatite obtained from porous wood, having high compressive strength and dimensions suitable for clinical applications. The porous wood has a porosity of between about 60% and about 95%, said porosity being measured after subjecting the wood to a step of pyrolysis, and is selected from among rattan, pine, abachi, balsa, sipo, oak, rosewood, kempas and walnut wood. The hydroxyapatite may be substituted with one or more ions such as magnesium, strontium, silicon, titanium, carbonate, potassium, sodium, silver, gallium, copper, iron, zinc, manganese, europium, gadolinium. Also disclosed is a bone substitute comprising hydroxyapatite obtained from porous wood. The bone substitute is utilized for the substitution and regeneration of a bone or a bone portion, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, fibula, femur, humerus and radius.Type: GrantFiled: May 15, 2020Date of Patent: June 14, 2022Assignee: GREENBONE ORTHO S.R.L.Inventors: Anna Tampieri, Simone Sprio, Andrea Ruffini
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Patent number: 11213605Abstract: The present disclosure relates to a hydroxyapatite obtained from porous wood, having high compressive strength and dimensions suitable for clinical applications. The porous wood has a porosity of between about 60% and about 95%, said porosity being measured after subjecting the wood to a step of pyrolysis, and is selected from among rattan, pine, abachi, balsa, sipo, oak, rosewood, kempas and walnut wood. The hydroxyapatite may be substituted with one or more ions such as magnesium, strontium, silicon, titanium, carbonate, potassium, sodium, silver, gallium, copper, iron, zinc, manganese, europium, gadolinium. Also disclosed is a bone substitute comprising hydroxyapatite obtained from porous wood. The bone substitute is utilized for the substitution and regeneration of a bone or a bone portion, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, fibula, femur, humerus and radius.Type: GrantFiled: May 15, 2020Date of Patent: January 4, 2022Assignee: GREENBONE ORTHO S.P.A.Inventors: Anna Tampieri, Simone Sprio, Andrea Ruffini
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Publication number: 20210316263Abstract: A system for chemical transformation of 3D state materials is disclosed wherein, a reaction group having a main body arranged to shape a reaction chamber in which a component configured to support a sample of 3D state arranged to be chemically transform is expected. The system further includes an oven arranged to heat the reaction chamber and a GAS supply group arranged to release a first gas in the reaction chamber and/or a casing component, inside the main body, which has a chemical agent suitable for releasing a second gas into the reaction chamber. The main body has at least two turbines arranged to converge into the reaction chamber, the first and/or the second gas on the samples. The invention relates also to a method for chemical transformation of 3D state materials.Type: ApplicationFiled: July 26, 2019Publication date: October 14, 2021Applicant: GREENBONE ORTHO S.P.A.Inventors: Lorenzo Giuseppe PRADELLA, Alberto BALLARDINI, Lorenzo SANTI, Anna TAMPIERI, Simone SPRIO, Andrea RUFFINI
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STABILIZED AMORPHOUS CALCIUM PHOSPHATE DOPED WITH FLUORIDE IONS AND A PROCESS FOR PRODUCING THE SAME
Publication number: 20210276869Abstract: The invention relates to a process for the preparation of a citrate-coated amorphous calcium phosphate nanoparticle which comprises the following steps: 1) providing a first solution of a salt of calcium and a citrate salt wherein the molar ratio of citrate ion to calcium ion is in the range from 1 to 2 thus obtaining a clear first solution; 2) providing a second solution of a salt capable to give phosphate anion and a carbonate salt; 3) mixing together the first and the second solution at a pH in the range from 8 to 11; 4) precipitating the nanoparticle; and 5) drying the nanoparticle obtained from step 4). Preferably and advantageously the invention provides for the addition of a fluoride compound in step 2) for obtaining a fluorine-doped citrate-coated calcium phosphate nanoparticle or a nanoparticle agglomerate. The nanoparticle/nanoparticle agglomerate of the invention has a peculiar superficial area and a diameter that allow to use it as a biomaterial for dentistry application.Type: ApplicationFiled: June 27, 2019Publication date: September 9, 2021Inventors: Michele IAFISCO, Anna TAMPIERI -
Patent number: 10813856Abstract: The present invention relates to a composition for the protection against solar radiation, consisting of an organic matrix, preferably a gelatin, and hydroxyapatite nanoparticles modified by the substitution of part of the phosphorus with titanium, and part of the calcium with iron.Type: GrantFiled: March 6, 2017Date of Patent: October 27, 2020Assignee: CONSIGLIO NAZIONALE DELLE RICERCHEInventors: Anna Tampieri, Monica Sandri, Simone Sprio
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Publication number: 20200276356Abstract: The present disclosure relates to a hydroxyapatite obtained from porous wood, having high compressive strength and dimensions suitable for clinical applications. The porous wood has a porosity of between about 60% and about 95%, said porosity being measured after subjecting the wood to a step of pyrolysis, and is selected from among rattan, pine, abachi, halsa, sipo, oak, rosewood, kempas and walnut wood. The hydroxyapatite may be substituted with one or more ions such as magnesium, strontium, silicon, titanium, carbonate, potassium, sodium, silver, gallium, copper, iron, zinc, manganese, europium, gadolinium. Also disclosed is a bone substitute comprising hydroxyapatite obtained from porous wood. The bone substitute is utilized for the substitution and regeneration of a bone or a bone portion, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, fibula, femur, humerus and radius.Type: ApplicationFiled: May 15, 2020Publication date: September 3, 2020Inventors: Anna TAMPIERI, Simone Sprio, Andrea Ruffini
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Publication number: 20200276355Abstract: The present disclosure relates to a hydroxyapatite obtained from porous wood, having high compressive strength and dimensions suitable for clinical applications. The porous wood has a porosity of between about 60% and about 95%, said porosity being measured after subjecting the wood to a step of pyrolysis, and is selected from among rattan, pine, abachi, balsa, sipo, oak, rosewood, kempas and walnut wood. The hydroxyapatite may be substituted with one or more ions such as magnesium, strontium, silicon, titanium, carbonate, potassium, sodium, silver, gallium, copper, iron, zinc, manganese, europium, gadolinium. Also disclosed is a bone substitute comprising hydroxyapatite obtained from porous wood. The bone substitute is utilized for the substitution and regeneration of a bone or a bone portion, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, fibula, femur, humerus and radius.Type: ApplicationFiled: May 15, 2020Publication date: September 3, 2020Inventors: Anna TAMPIERI, Simone SPRIO, Andrea RUFFINI
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Patent number: 10729660Abstract: The invention relates to a process for the preparation of a product comprising one or more nanoparticles of calcium phosphate (CaP-NP) with negative surface charge having a ?-potential in the range from ?41.0 mV to ?27.0 mV comprising the steps of: a) maintaining a mixture having a pH in the range from 7 to 10 and comprising an aqueous solution of calcium, an aqueous solution of phosphate and a solution of citrate ions at a temperature in the range from 20° C. to 40° C. for a time in the range from 30 seconds to 10 minutes; b) removing non-reacted ions from the solution of step a), thus obtaining a suspension of one or more nanoparticles of calcium phosphate (CaP-NP); c) recovering the product of one or more nanoparticles of calcium phosphate (CaP-NP) from the suspension of step b). In an advantageous embodiment, the process of the invention provides, in the mixture of step a), also an aqueous solution of one or more therapeutic/diagnostic compounds.Type: GrantFiled: December 22, 2015Date of Patent: August 4, 2020Assignees: CONSIGLIO NAZIONALE DELLE RICHERCHE ISTITUTO NAZIONALE PER L'ASSICURAZIONE, CONTRO GLI INFORTUNI SUL LAVOROInventors: Daniele Catalucci, Michele Miragoli, Michele Iafisco, Anna Tampieri
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Patent number: 10688218Abstract: The present disclosure relates to a hydroxyapatite obtained from porous wood, having high compressive strength and dimensions suitable for clinical applications. The porous wood has a porosity of between about 60% and about 95%, said porosity being measured after subjecting the wood to a step of pyrolysis, and is selected from among rattan, pine, abachi, balsa, sipo, oak, rosewood, kempas and walnut wood. The hydroxyapatite may be substituted with one or more ions such as magnesium, strontium, silicon, titanium, carbonate, potassium, sodium, silver, gallium, copper, iron, zinc, manganese, europium, gadolinium. Also disclosed is a bone substitute comprising hydroxyapatite obtained from porous wood. The bone substitute is utilized for the substitution and regeneration of a bone or a bone portion, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, fibula, femur, humerus and radius.Type: GrantFiled: August 3, 2016Date of Patent: June 23, 2020Assignee: GREENBONE ORTHO S.R.L.Inventors: Anna Tampieri, Simone Sprio, Andrea Ruffini
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Publication number: 20200030566Abstract: Filter made entirely with natural and biodegradable materials, for the protection of the respiratory tract of patients in the medical-surgical field and process for making it. The filter has a porosity or 80-98% and pore diameters of 100-350 micrometers and the pores have a shape of channels open at the ends, which are parallel to each other. The filter is obtained by preparing an aqueous solution of chitosan and an aqueous solution of gelatin, mixing them, pouring it into a container, keeping the container closed until obtaining a hydrogel and freeze-drying. A cross-linking step takes place by (a) adding a chemical cross-linker to the mixture of the chitosan and gelatine solutions and cross-linking before freeze-drying, or (b) subjecting the freeze-drying product to a thermal dehydration treatment.Type: ApplicationFiled: February 27, 2018Publication date: January 30, 2020Inventors: Monica SANDRI, Anna TAMPIERI, Simone SPRIO
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Publication number: 20190070079Abstract: The present invention relates to a composition for the protection against solar radiation, consisting of an organic matrix, preferably a gelatin, and hydroxyapatite nanoparticles modified by the substitution of part of the phosphorus with titanium, and part of the calcium with iron.Type: ApplicationFiled: March 6, 2017Publication date: March 7, 2019Inventors: Anna TAMPIERI, Monica SANDRI, Simone SPRIO
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Publication number: 20190008997Abstract: The present disclosure relates to a hydroxyapatite obtained from porous wood, having high compressive strength and dimensions suitable for clinical applications. The porous wood has a porosity of between about 60% and about 95%, said porosity being measured after subjecting the wood to a step of pyrolysis, and is selected from among rattan, pine, abachi, balsa, sipo, oak, rosewood, kempas and walnut wood. The hydroxyapatite may be substituted with one or more ions such as magnesium, strontium, silicon, titanium, carbonate, potassium, sodium, silver, gallium, copper, iron, zinc, manganese, europium, gadolinium. Also disclosed is a bone substitute comprising hydroxyapatite obtained from porous wood. The bone substitute is utilized for the substitution and regeneration of a bone or a bone portion, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, fibula, femur, humerus and radius.Type: ApplicationFiled: August 3, 2016Publication date: January 10, 2019Inventors: Anna TAMPIERI, Simone SPRIO, Andrea RUFFINI
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Patent number: 10105390Abstract: Process for obtaining fluoride-doped citrate-coated amorphous calcium phosphate nanoparticles. This material has applications in biomedicine due to its biodegradability and bioactivity; it also promotes cell adhesion and osteogeneration. In dentistry, it may be used in toothpastes, mouthwashes, chewing gums, gels and fluoride varnishes as a remineralising agent of dentine and enamel. It is based on two solutions formed by calcium chloride and sodium citrate on the one hand, and by sodium monohydrogenophosphate and sodium carbonate with a fluoride compound on the other, which are mixed at room temperature. The process is eco-efficient and eco-friendly, as it does not leave any acid residue; it consists of a single stage and it is the first time that an amorphous calcium phosphate coated with citrate and doped with fluoride, which enhances its remineralising action, is obtained.Type: GrantFiled: July 21, 2015Date of Patent: October 23, 2018Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)Inventors: Jose Manuel Delgado Lopez, Jaime Gomez Morales, Raquel Fernandez Penas, Michele Iafisco, Anna Tampieri, Silvia Panseri
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Publication number: 20170348245Abstract: The invention relates to a process for the preparation of a product comprising one or more nanoparticles of calcium phosphate (CaP-NP) with negative surface charge having a ?-potential in the range from ?41.0 mV to ?27.0 mV comprising the steps of: a) maintaining a mixture having a pH in the range from 7 to 10 and comprising an aqueous solution of calcium, an aqueous solution of phosphate and a solution of citrate ions at a temperature in the range from 20° C. to 40° C. for a time in the range from 30 seconds to 10 minutes; b) removing non-reacted ions from the solution of step a), thus obtaining a suspension of one or more nanoparticles of calcium phosphate (CaP-NP); c) recovering the product of one or more nanoparticles of calcium phosphate (CaP-NP) from the suspension of step b). In an advantageous embodiment, the process of the invention provides, in the mixture of step a), also an aqueous solution of one or more therapeutic/diagnostic compounds.Type: ApplicationFiled: December 22, 2015Publication date: December 7, 2017Inventors: Daniele CATALUCCI, Michele MIRAGOLI, Michele IAFISCO, Anna TAMPIERI
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Publication number: 20170209491Abstract: Process for obtaining fluoride-doped citrate-coated amorphous calcium phosphate nanoparticles. This material has applications in biomedicine due to its biodegradability and bioactivity; it also promotes cell adhesion and osteogeneration. In dentistry, it may be used in toothpastes, mouthwashes, chewing gums, gels and fluoride varnishes as a remineralising agent of dentine and enamel. It is based on two solutions formed by calcium chloride and sodium citrate on the one hand, and by sodium monohydrogenophosphate and sodium carbonate with a fluoride compound on the other, which are mixed at room temperature. The process is eco-efficient and eco-friendly, as it does not leave any acid residue; it consists of a single stage and it is the first time that an amorphous calcium phosphate coated with citrate and doped with fluoride, which enhances its remineralising action, is obtained.Type: ApplicationFiled: July 21, 2015Publication date: July 27, 2017Applicants: Consejo Superior De Investigaciones Científicas (C SIC), Consiglio Nazionale Delle RicercheInventors: Jose Manuel Delgado Lopez, Jaime Gomez Morales, Raquel Fernandez Penas, Michele Iafisco, Anna Tampieri, Silvia Panseri
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Patent number: 9327027Abstract: The present invention relates to hydroxyapatite doped with Fe2+ ions and Fe3+ ions which partially substitute the calcium ions in the crystal lattice. The hydroxyapatite is characterized by an intrinsic magnetism of 0.05 to 8 emu/g, measured by applying a magnetic field of 34 Oe, due to the presence of magnetic nano-domains in the crystal lattice of HA, given the limited amount of magnetic secondary phases present, less than about 3% by volume. The intrinsically magnetic hydroxyapatite can be loaded with biological substances selected in the group consisting of proteins, genes, stem cells, growth factors, vascularization factors, active substances and drugs, under the control of an external magnetic field, as a carrier and release agent for biological substances or drugs, as a contrast agent in diagnostics or for bone or osteocartilage regeneration.Type: GrantFiled: July 28, 2011Date of Patent: May 3, 2016Assignees: CONSIGLIO NAZIONALE DELLE RICERCHE, UNIVERSIDADE DE SANTIAGO DE COMPOSTELA, FIN-CERAMICA FAENZA S.P.A.Inventors: Anna Tampieri, Elena Landi, Monica Sandri, Daniele Pressato, José Rivas Rey, Manuel Banobre López, Maurilio Marcacci
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Patent number: 9326948Abstract: The present invention relates to a bone substitute comprising a core based on hydroxyapatite (HA), obtained from at least one porous wood, or based on collagen fibers and hydroxyapatite, and a shell, based on hydroxyapatite (HA) or silicon carbide (SiC), obtained from at least one wood having a lower porosity than the at least one wood of the core. The porous wood has a total porosity of between 60% and 95%, preferably between 65% and 85%, and it is selected from amongst the choices of rattan, pine, abachi and balsa wood. The wood of the shell has a porosity of between 20% and 60%, preferably between 30% and 50%. The bone substitute is utilized for the substitution and regeneration of bone, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, metatarsus, femur, humerus or radius.Type: GrantFiled: November 8, 2011Date of Patent: May 3, 2016Assignee: CONSIGLIO NAZIONALE DELLE RICERCHEInventors: Anna Tampieri, Simone Sprio, Andrea Ruffini, Julia Will, Peter Greil, Frank Muller, Julian Martinez Fernandez, Carmen Torres Raya, Francisco Manuel Varela Feria, Joaquin Ramirez Rico, Marie-Francoise Harmand
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Patent number: 9327976Abstract: The present invention relates to a hydroxyapatite multi-substituted with, physiologically compatible ion species and to its biohybrid composite with a natural and/or synthetic polymer, which are useful in the preparation of a biomimetic bone substitute for treating bone tissue defects. Furthermore, the present invention relates to a method for their preparation and uses.Type: GrantFiled: October 12, 2006Date of Patent: May 3, 2016Assignees: C.N.R. CONSIGLIO NAZIONALE DELLE RICERCHE, FIN-CERAMICA FAENZA S.P.A.Inventors: Elena Landi, Anna Tampieri, Giancarlo Celotti, Simone Sprio, Daniele Pressato, Claudio De Luca