Patents by Inventor Anna V. ELISEENKOVA

Anna V. ELISEENKOVA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibiting binding of FGF23 to the binary FGFR-Klotho complex for the treatment of hypophosphatemia
    Patent number: 8889621
    Abstract: The present invention is directed to a method of treating hypophosphatemia in a subject. This method involves selecting a subject with hypophosphatemia associated with elevated or normal FGF23 and administering to the selected subject an inhibitor of FGF23-Klotho-FGF receptor complex formation under conditions effective to treat the hypophosphatemia.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: November 18, 2014
    Assignee: New York University
    Inventors: Moosa Mohammadi, Regina Goetz, Anna V. Eliseenkova
  • Methods of identifying inhibitors of FGF23 binding to the binary FGFR-klotho complex for the treatment of hypophosphatemia
    Patent number: 8889426
    Abstract: The present invention is directed to a method of treating hypophosphatemia in a subject. The present invention is also directed to a method of screening for compounds suitable for treatment of hypophosphatemia associated with elevated or normal FGF23. This method involves providing FGF23, FGFR-Klotho complex, and one or more candidate compounds. The FGF23, the FGFR-Klotho complex, and the candidate compounds are combined under conditions effective for the FGF23 and the binary FGFR-Klotho complex to form a ternary complex if present by themselves. This method also involves identifying the candidate compounds, which prevent formation of the complex as being potentially suitable in treating hypophosphatemic conditions associated with elevated or normal FGF23. A method of screening the specificity of compounds which prevent formation of the FGF23-Klotho-FGFR complex is also disclosed.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: November 18, 2014
    Assignee: New York University
    Inventors: Moosa Mohammadi, Regina Goetz, Anna V. Eliseenkova
  • INHIBITING BINDING OF FGF23 TO THE BINARY FGFR-KLOTHO COMPLEX FOR THE TREATMENT OF HYPOPHOSPHATEMIA
    Publication number: 20120288886
    Abstract: The present invention is directed to a method of treating hypophosphatemia in a subject. The present invention is also directed to a method of screening for compounds suitable for treatment of hypophosphatemia associated with elevated or normal FGF23. This method involves providing FGF23, FGFR-Klotho complex, and one or more candidate compounds. The FGF23, the FGFR-Klotho complex, and the candidate compounds are combined under conditions effective for the FGF23 and the binary FGFR-Klotho complex to form a ternary complex if present by themselves. This method also involves identifying the candidate compounds, which prevent formation of the complex as being potentially suitable in treating hypophosphatemic conditions associated with elevated or normal FGF23. A method of screening the specificity of compounds which prevent formation of the FGF23-Klotho-FGFR complex is also disclosed.
    Type: Application
    Filed: May 18, 2012
    Publication date: November 15, 2012
    Applicant: NEW YORK UNIVERSITY
    Inventors: Moosa MOHAMMADI, Regina GOETZ, Anna V. ELISEENKOVA
  • INHIBITING BINDING OF FGF23 TO THE BINARY FGFR-KLOTHO COMPLEX FOR THE TREATMENT OF HYPOPHOSPHATEMIA
    Publication number: 20110190207
    Abstract: The present invention is directed to a method of treating hypophosphatemia in a subject. This method involves selecting a subject with hypophosphatemia associated with elevated or normal FGF23 and administering to the selected subject an inhibitor of FGF23-Klotho-FGF receptor complex formation under conditions effective to treat the hypophosphatemia. The present invention is also directed to a method of screening for compounds suitable for treatment of hypophosphatemia associated with elevated or normal FGF23. This method involves providing FGF23, FGFR-Klotho complex, and one or more candidate compounds. The FGF23, the FGFR-Klotho complex, and the candidate compounds are combined under conditions effective for the FGF23 and the binary FGFR-Klotho complex to form a ternary complex if present by themselves.
    Type: Application
    Filed: October 29, 2010
    Publication date: August 4, 2011
    Applicant: NEW YORK UNIVERSITY
    Inventors: Moosa MOHAMMADI, Regina GOETZ, Anna V. ELISEENKOVA