Patent number: 9585942
Abstract: The invention relates to an insulin analogue or its pharmaceutically acceptable salt, pharmaceutical composition with prolonged therapeutic effect, application of the insulin analogue, dosage method and method of treatment of diabetes. In more detail, the solution pertains to compounds being stable insulin analogues which are pharmaceutically active and characterized by a prolonged, flat, truly peakless course of glucose concentration vs. time during repeated administration and which do not show strong 24 hours fluctuations of glucose concentration, or the so-called “sawteeth effect”, during this time. Results of studies of compounds included in the scope of this application indicate an improvement in the effects of diabetes treatment by avoiding the hitherto occurring adverse influence of changes in glucose concentration throughout the entire day on a patient's organism, e.g.
Type:
Grant
Filed:
May 22, 2013
Date of Patent:
March 7, 2017
Assignee:
Instytut Biotechnologii i Antybiotykow
Inventors:
Piotr Borowicz, Andrzej Płucienniczak, Jerzy Mikołajczyk, Jarosław Antosik, Jacek Pstrzoch, Justyna Bernat, Diana Mikiewicz-Syguła, Monika Bogiel, Dorota Stadnik, Graźyna Płucienniczak, Boźena Tejchman-Małecka, Tadeusz Głąbski, Iwona Sokołowska, Dariusz Kurzynoga, Anna Wojtowicz-Krawiec, Marcin Zieliński, Malgorzata Kęsik-Brodacka, Natalia Łukasiewicz, Violetta Cecuda-Adamczewska, Monika Pawłowska, Tomasz Pawlukowiec, Jacek Stępniewski