Abstract: Provided herein are methods and systems to selectively deplete a biological sample of host compartments and/or host nucleic acid while enriching the sample microbial compartments and/or related microbial nucleic acid. In addition, provided herein are compositions, methods and systems related to said host depletion and microbial enrichment methods and systems.

Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to the use of volatile compositions to limit, decrease or eliminate the perception of malodor. Such compositions include at least one malodor antagonist optionally combined with perfuming ingredients. Such compositions, their use in combination with delivery systems and their applications in consumer products are also objects of the present disclosure.

Abstract: An unmanned aerial vehicle (UAV) device and the manufacturing process to make the UAV. The UAV device comprises a monocoque shell with a single-piece molded construction that includes a central body and arms that extend outward from the central body. Each of the arms includes a terminal end that is spaced away from the central body. The monocoque shell has a cupped shape with a closed first side and an open second side that includes sidewalls that extend around an interior space. The UAV device comprises a plurality of motors and rotors attached to the first side of the monocoque shell with one of said plurality of motors and rotors positioned at the terminal end of each of the arms.

Abstract: A system and method for mapping text phrases to geographical locations is provided. Entities, each comprising one of a location, person, and place, are identified in one or more documents. Possible candidate locations associated with each entity are determined. An initial score is assigned to each location. The initial scores are adjusted and the candidate location with the highest adjusted score is selected for each entity. The selected candidate location is applied to all occurrences of the entity in the documents.

Abstract: The application discloses an unmanned aerial vehicle (UAV) device and the manufacturing process to make the UAV. The UAV device comprises a monocoque shell with a single-piece molded construction that includes a central body and arms that extend outward from the central body. Each of the arms includes a terminal end that is spaced away from the central body. The monocoque shell has a cupped shape with a closed first side and an open second side that includes sidewalls that extend around an interior space. The UAV device comprises a plurality of motors and rotors attached to the first side of the monocoque shell with one of said plurality of motors and rotors positioned at the terminal end of each of the arms.

Abstract: A system and method for mapping text phrases to geographical locations is provided. Entities, each comprising one of a location, person, and place, are identified in one or more documents. Possible candidate locations associated with each entity are determined. An initial score is assigned to each location. The initial scores are adjusted and the candidate location with the highest adjusted score is selected for each entity. The selected candidate location is applied to all occurrences of the entity in the documents.

Abstract: Embodiments of the present invention utilize a more efficient CDR grafting technique to generate humanized versions of the T84.66 antibody. The technique used to generate these antibodies utilizes crystallographic structural data to select an immunoglobulin framework having maximum structural overlap with a non-human donor molecule. This technique was used to develop humanized T84.66 antibodies exhibiting in vitro binding affinity and specificity for carcinoembryonic antigen (CEA) nearly identical to that of T84.66 and the ability to specifically target tumors expressing CEA in vivo.

Abstract: The present invention provides anti-CD20 antibody fragments for use as in vivo imaging probes and as therapeutic moieties for the diagnosis and treatment of NHL.

Abstract: Prostate stem cell antigen (PSCA) is expressed in the majority of prostate cancer patients, making it an ideal target for cancer immunotherapy. Murine monoclonal antibody 1G8 binds to PSCA with nanomolar affinity, but its efficacy as a therapeutic agent is limited by the generation of a HAMA response. The present invention discloses humanized 1G8 antibodies in which the majority of the mouse-derived epitopes have been removed. These humanized antibodies bind PSCA with high affinity and specificity, and have been shown to reduce human bladder tumor take in a nude mouse model. These characteristics make the humanized antibodies of the present invention attractive agents for the treatment and detection of tumors expressing PSCA.

Abstract: Embodiments of the present invention utilize a more efficient CDR grafting technique to generate humanized versions of the T84.66 antibody. The technique used to generate these antibodies utilizes crystallographic structural data to select an immunoglobulin framework having maximum structural overlap with a non-human donor molecule. This technique was used to develop humanized T84.66 antibodies exhibiting in vitro binding affinity and specificity for carcinoembryonic antigen (CEA) nearly identical to that of T84.66 and the ability to specifically target tumors expressing CEA in vivo.

Abstract: Genetically engineered, CD20-specific redirected T cells expressing a cell surface protein-having an extracellular domain comprising a receptor which is specific for CD20, an intracellular signaling domain, and a transmembrane domain. Use of such cells for cellular immunotherapy of CD20+ malignancies and for abrogating any untoward B cell function. In one embodiment, the cell surface protein is a single chain FvFc:&zgr; receptor where Fv designates the VH and VL chains of a single chain monoclonal antibody to CD20 linked by peptide, Fc represents a hinge-CH2-CH3 region of a human IgG1, and &zgr; represents the intracellular signaling domain of the zeta chain of human CD3. A method of making a redirected T cell expressing a chimeric T cell receptor by electroporation using naked DNA encoding the receptor.