Patents by Inventor Annalee Nguyen

Annalee Nguyen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIGH AFFINITY ENGINEERED T-CELL RECEPTORS TARGETING CMV INFECTED CELLS
    Publication number: 20220144916
    Abstract: Provided herein are engineered T-cell receptors (TCRs) having nanomolar affinity for the immuno-dominant pp65 peptide residing between residues 495-503 (NLV) in complex with HLA-A2*02:01. The TCRs may be membrane-hound TCRs, soluble TCRs, chimeric TCRs, or chimeric antigen receptors. Also provided are methods of using the engineered TCRs to treat diseases, monitor disease progression, monitor vaccine efficacy, and detecting NLV/A2 presentation on the surface of cells.
    Type: Application
    Filed: February 12, 2020
    Publication date: May 12, 2022
    Inventors: Jennifer A. MAYNARD, Ellen WAGNER, Ahlam N. QERQEZ, Annalee NGUYEN
  • STABILIZED PERTUSSIS ANTIBODIES WITH EXTENDED HALF-LIFE
    Publication number: 20210332112
    Abstract: The present invention relates, in part, to modified humanized antibodies which bind the pertussis toxin protein and their use as therapeutic agents. In particular, the present invention is directed, in part, to improved humanized 1B7 and 11E6 antibodies with extended in vivo half-lives.
    Type: Application
    Filed: August 15, 2017
    Publication date: October 28, 2021
    Inventors: Jennifer MAYNARD, Annalee NGUYEN, Michael KALEKO
  • Humanized pertussis antibodies and used thereof
    Patent number: 10526400
    Abstract: The present invention relates to humanized antibodies which bind the pertussis toxin protein and their use as therapeutic agents. In particular, the present invention is directed to improved humanized 1B7 and 11E6 antibodies which bind the pertussis toxin protein.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: January 7, 2020
    Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, SYNTHETIC BIOLOGICS, INC.
    Inventors: Jennifer Maynard, Annalee Nguyen, Eduardo Padlan, Ellen Wagner
  • Compositions for in situ nucleic acid analysis
    Patent number: 10501780
    Abstract: Sample preparation processes for in situ RNA or DNA analysis, methods and compositions therefor are provided. Processes provided herein allow DNA or RNA analysis to be carried out in the same tube or on an aliquot of the prepared sample without centrifugation or extraction. The preparation process can be carried out at room temperature in as little as seven minutes and is amenable to high throughput processing using manual or robotic platforms.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: December 10, 2019
    Assignee: APPLIED BIOSYSTEMS, LLC
    Inventors: Richard A. Fekete, Annalee Nguyen
  • HUMANIZED PERTUSSIS ANTIBODIES AND USES THEREOF
    Publication number: 20180362621
    Abstract: The present invention relates to humanized antibodies which bind the pertussis toxin protein and their use as therapeutic agents. In particular, the present invention is directed to improved humanized 1B7 and 11E6 antibodies which bind the pertussis toxin protein.
    Type: Application
    Filed: June 25, 2018
    Publication date: December 20, 2018
    Inventors: Jennifer Maynard, Annalee Nguyen, Eduardo Padlan, Ellen Wagner
  • Humanized pertussis antibodies and uses thereof
    Patent number: 10035846
    Abstract: The present invention relates to humanized antibodies which bind the pertussis toxin protein and their use as therapeutic agents. In particular, the present invention is directed to improved humanized 1B7 and 11E6 antibodies which bind the pertussis toxin protein.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: July 31, 2018
    Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, SYNTHETIC BIOLOGICS, INC.
    Inventors: Jennifer Maynard, Annalee Nguyen, Eduardo Padlan, Ellen Wagner
  • HUMANIZED PERTUSSIS ANTIBODIES AND USES THEREOF
    Publication number: 20170066816
    Abstract: The present invention relates to humanized antibodies which bind the pertussis toxin protein and their use as therapeutic agents. In particular, the present invention is directed to improved humanized 1B7 and 11E6 antibodies which bind the pertussis toxin protein.
    Type: Application
    Filed: November 18, 2016
    Publication date: March 9, 2017
    Inventors: Jennifer Maynard, Annalee Nguyen, Eduardo Padlan, Ellen Wagner
  • Humanized pertussis antibodies and uses thereof
    Patent number: 9512204
    Abstract: The present invention relates to humanized antibodies which bind the pertussis toxin protein and their use as therapeutic agents. In particular, the present invention is directed to improved humanized 1B7 and 11E6 antibodies which bind the pertussis toxin protein.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: December 6, 2016
    Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, SYNTHETIC BIOLOGICS, INC.
    Inventors: Jennifer Maynard, Annalee Nguyen, Eduardo Padlan, Ellen Wagner
  • SAMPLE PREPARATION FOR IN SITU NUCLEIC ACID ANALYSIS, METHODS AND COMPOSITIONS THEREFOR
    Publication number: 20160230220
    Abstract: Sample preparation processes for in situ RNA or DNA analysis, methods and compositions therefor are provided. Processes provided herein allow DNA or RNA analysis to be carried out in the same tube or on an aliquot of the prepared sample without centrifugation or extraction. The preparation process can be carried out at room temperature in as little as seven minutes and is amenable to high throughput processing using manual or robotic platforms.
    Type: Application
    Filed: February 11, 2016
    Publication date: August 11, 2016
    Inventors: Richard A. FEKETE, Annalee Nguyen
  • Sample preparation for in situ nucleic acid analysis, methods and compositions therefor
    Patent number: 9279152
    Abstract: Sample preparation processes for in situ RNA or DNA analysis, methods and compositions therefor are provided. Processes provided herein allow DNA or RNA analysis to be carried out in the same tube or on an aliquot of the prepared sample without centrifugation or extraction. The preparation process can be carried out at room temperature in as little as seven minutes and is amenable to high throughput processing using manual or robotic platforms.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: March 8, 2016
    Assignee: Applied Biosystems, LLC
    Inventors: Richard Fekete, Annalee Nguyen
  • HUMANIZED PERTUSSIS ANTIBODIES AND USES THEREOF
    Publication number: 20150353628
    Abstract: The present invention relates to humanized antibodies which bind the pertussis toxin protein and their use as therapeutic agents. In particular, the present invention is directed to improved humanized 1B7 and 11E6 antibodies which bind the pertussis toxin protein.
    Type: Application
    Filed: March 31, 2015
    Publication date: December 10, 2015
    Inventors: Jennifer Maynard, Annalee Nguyen, Eduardo Padlan
  • Sample Preparation for in Situ Nucleic Acid Analysis, Methods and Compositions Therefor
    Publication number: 20150050653
    Abstract: Sample preparation processes for in situ RNA or DNA analysis, methods and compositions therefor are provided. Processes provided herein allow DNA or RNA analysis to be carried out in the same tube or on an aliquot of the prepared sample without centrifugation or extraction. The preparation process can be carried out at room temperature in as little as seven minutes and is amenable to high throughput processing using manual or robotic platforms.
    Type: Application
    Filed: August 14, 2014
    Publication date: February 19, 2015
    Inventors: Richard FEKETE, Annalee NGUYEN
  • Sample preparation for in situ nucleic acid analysis, methods and compositions therefor
    Patent number: 8828664
    Abstract: Sample preparation processes for in situ RNA or DNA analysis, methods and compositions therefor are provided. Processes provided herein allow DNA or RNA analysis to be carried out in the same tube or on an aliquot of the prepared sample without centrifugation or extraction. The preparation process can be carried out at room temperature in as little as seven minutes and is amenable to high throughput processing using manual or robotic platforms.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: September 9, 2014
    Assignee: Applied Biosystems, LLC.
    Inventors: Richard Fekete, Annalee Nguyen
  • Sample Preparation for in Situ Nucleic Acid Analysis, Methods and Compositions Therefor
    Publication number: 20140127692
    Abstract: Sample preparation processes for in situ RNA or DNA analysis, methods and compositions therefor are provided. Processes provided herein allow DNA or RNA analysis to be carried out in the same tube or on an aliquot of the prepared sample without centrifugation or extraction. The preparation process can be carried out at room temperature in as little as seven minutes and is amenable to high throughput processing using manual or robotic platforms.
    Type: Application
    Filed: December 20, 2013
    Publication date: May 8, 2014
    Applicant: APPLIED BIOSYSTEMS, LLC
    Inventors: RICHARD FEKETE, ANNALEE NGUYEN
  • Sample preparation for in situ nucleic acid analysis, methods and compositions therefor
    Patent number: 8288106
    Abstract: Sample preparation processes for in situ RNA or DNA analysis, methods and compositions therefor are provided. Processes provided herein allow DNA or RNA analysis to be carried out in the same tube or on an aliquot of the prepared sample without centrifugation or extraction. The preparation process can be carried out at room temperature in as little as seven minutes and is amenable to high throughput processing using manual or robotic platforms.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: October 16, 2012
    Assignee: Applied Biosystems, LLC
    Inventors: Richard A. Fekete, Annalee Nguyen
  • SAMPLE PREPARATION FOR IN SITU NUCLEIC ACID ANALYSIS, METHODS AND COMPOSITIONS THEREFOR
    Publication number: 20120003656
    Abstract: Sample preparation processes for in situ RNA or DNA analysis, methods and compositions therefor are provided. Processes provided herein allow DNA or RNA analysis to be carried out in the same tube or on an aliquot of the prepared sample without centrifugation or extraction. The preparation process can be carried out at room temperature in as little as seven minutes and is amenable to high throughput processing using manual or robotic platforms.
    Type: Application
    Filed: June 10, 2011
    Publication date: January 5, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Richard A. Fekete, Annalee Nguyen
  • Sample preparation for in situ nucleic acid analysis
    Patent number: 7964350
    Abstract: Sample preparation processes for in situ RNA or DNA analysis, methods and compositions therefor are provided. Processes provided herein allow DNA or RNA analysis to be carried out in the same tube or on an aliquot of the prepared sample without centrifugation or extraction. The preparation process can be carried out at room temperature in as little as seven minutes and is amenable to high throughput processing using manual or robotic platforms.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: June 21, 2011
    Assignee: Applied Biosystems, LLC
    Inventors: Richard A. Fekete, Annalee Nguyen