Abstract: This disclosure provides a composition and a method for enhancing urolithin B production. As a result of this, due to known impact of urolithin B, this can enhance reverse cholesterol transport and HDL function and management of plasma lipid profile through enhanced production of urolithin B from pomegranate polyphenols by administering a composition comprising a synergistic mixture of pomegranate polyphenols, lycopene and quercetin. The improved HDL function and lipid profile of such composition may be attributed to the enhanced urolithin B production made possible by the combination. Increasing the levels of urolithin B through modulation of the intestinal microbiome metabolism of pomegranate polyphenols is a potential therapeutic target for managing these diseases.

Abstract: This disclosure provides a composition comprising a synergistic mixture of hemp oil extract and palmitoylethanolamide (PEA), and a method for suppressing inflammatory and neuropathic pain by administering the composition to a subject. The anti-inflammatory and antinociceptive properties of the composition may be attributed by the entourage effect on the endocannabinoid system. Increasing the levels of endocannabinoids by inhibiting either their degradation or transport from the extracellular space back into the cells is a potential therapeutic target for managing these diseases.