Patents by Inventor Annamalai Selvakumar

Annamalai Selvakumar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunogenic WT-1 peptides and methods of use thereof
    Patent number: 10815274
    Abstract: This invention provides peptides, immunogenic compositions and vaccines, and methods of treating, reducing the incidence of, and inducing immune responses to a WT-1-expressing cancer, comprising peptides derived from the WT-1 protein.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: October 27, 2020
    Assignee: MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: Richard O'Reilly, Ekaterina Doubrovina, Annamalai Selvakumar
  • USE OF THE IL-15/IL-15RA COMPLEX IN THE GENERATION OF ANTIGEN-SPECIFIC T CELLS FOR ADOPTIVE IMMUNOTHERAPY
    Publication number: 20200157502
    Abstract: Provided herein are methods of generating antigen-specific T cells for therapeutic administration to a human patient having or suspected of having a pathogen or cancer, utilizing soluble IL-15/IL-15R? complexes ex vivo, in cell culture during ex vivo sensitizing of T cells to the antigen or during ex vivo culturing of antigen-specific T cells. Also disclosed are antigen-specific T cells generated by such methods, and methods of treating a human patient using such antigen-specific T cells. Cell culture systems comprising human T cells, antigen-presenting cells, and soluble IL-15/IL-15R? complexes are also provided.
    Type: Application
    Filed: May 25, 2017
    Publication date: May 21, 2020
    Applicant: Memorial Sloan Kettering Cancer Center
    Inventors: Richard John O'Reilly, Bo Dupont, Aisha Nasreen Hasan, Annamalai Selvakumar, Xiao-Rong Liu
  • IMMUNOGENIC WT-1 PEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20190092813
    Abstract: This invention provides peptides, immunogenic compositions and vaccines, and methods of treating, reducing the incidence of, and inducing immune responses to a WT-1-expressing cancer, comprising peptides derived from the WT-1 protein.
    Type: Application
    Filed: September 7, 2018
    Publication date: March 28, 2019
    Applicant: Memorial Sloan Kettering Cancer Center
    Inventors: Richard O'REILLY, EKATERINA DOUBROVINA, ANNAMALAI SELVAKUMAR
  • Immunogenic WT-1 peptides and methods of use thereof
    Patent number: 10100087
    Abstract: This invention provides peptides, immunogenic compositions and vaccines, and methods of treating, reducing the incidence of, and inducing immune responses to a WT-1-expressing cancer, comprising peptides derived from the WT-1 protein.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: October 16, 2018
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: Richard J. O'Reilly, Ekaterina Doubrovina, Annamalai Selvakumar
  • IMMUNOGENIC WT-1 PEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20170334951
    Abstract: This invention provides peptides, immunogenic compositions and vaccines, and methods of treating, reducing the incidence of, and inducing immune responses to a WT-1-expressing cancer, comprising peptides derived from the WT-1 protein.
    Type: Application
    Filed: May 30, 2017
    Publication date: November 23, 2017
    Applicant: Memorial Sloan Kettering Cancer Center
    Inventors: Richard J. O'Reilly, Ekaterina Doubrovina, Annamalai Selvakumar
  • IMMUNOGENIC WT-1 PEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20150104413
    Abstract: This invention provides peptides, immunogenic compositions and vaccines, and methods of treating, reducing the incidence of, and inducing immune responses to a WT-1-expressing cancer, comprising peptides derived from the WT-1 protein.
    Type: Application
    Filed: January 14, 2013
    Publication date: April 16, 2015
    Applicant: MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: Richard J. O'Reilly, Ekaterina Doubrovina, Annamalai Selvakumar