Patents by Inventor Annamaria Casazza

Annamaria Casazza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antitumor anthracycline glycosides, their preparation, intermediates therefor, and compositions and use thereof
    Patent number: 4393052
    Abstract: Novel antitumor anthracycline glycosides are prepared by condensing daunomycinone with 2,3,4,6-tetradeoxy-4-C-methylene-3-trifluoroacetamido-L-threo-hexopyranosy l chloride; 2,3,4,6-tetradeoxy-4-C-methylene-3-trifluoroacetamido-L-arabino-hexopyrano syl chloride or 2,3,6-trideoxy-4-C-trifluoroacetamidomethyl-3-trifluoroacetamido-3-O-trifl uoroacetyl-L-lyxo-hexopyranosyl chloride.
    Type: Grant
    Filed: October 29, 1981
    Date of Patent: July 12, 1983
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Alberto Bargiotti, Giuseppe Cassinelli, Sergio Penco, Federico Arcamone, Annamaria Casazza
  • Antitumor anthracycline glycosides, their preparation, intermediates therefor, and compositions and use thereof
    Patent number: 4366149
    Abstract: Novel antitumor anthracycline glycosides are prepared by condensing daunomycinone with 2,3,4,6-tetradeoxy-3,4-ditrifluoroacetamido-L-lyxo-[or L-arabino-]hexopyranosyl chloride.
    Type: Grant
    Filed: October 29, 1981
    Date of Patent: December 28, 1982
    Inventors: Alberto Bargiotti, Giuseppe Cassinelli, Sergio Penco, Federico Arcamone, Annamaria Casazza
  • 4-Demethoxy-4'-deoxydoxorubicin
    Patent number: 4325947
    Abstract: A new anthracycline glycoside, which is 4-demethoxy-4'-deoxydoxorubicin, provided with outstanding antitumoral activity also by oral route, has been prepared by condensation of 4-demethoxydaunomycinone with 2,3,4,6-tetradeoxy-3-trifluoroacetamido-L-threo-hexopyranosyl chloride.By elimination of the protecting group from the so obtained glycoside through a mild alkaline hydrolysis, 4-demethoxy-4'-deoxydaunorubicin was obtained which was successively brominated to give the corresponding 14-bromo derivative. By a subsequent hydrolysis with sodium formate the brominated intermediate was transformed into 4-demethoxy-4'-deoxydoxorubicin eventually isolated as its hydrochloride.
    Type: Grant
    Filed: May 12, 1981
    Date of Patent: April 20, 1982
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Sergio Penco, Giuliano Franchi, Federico Arcamone, Annamaria Casazza