Patents by Inventor Annarita DiLorenzo

Annarita DiLorenzo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ApoM-Fc fusion proteins, complexes thereof with sphingosine 1-phosphate (S1P), and methods for treating vascular and non-vascular diseases
    Patent number: 10870689
    Abstract: The present disclosure is directed to an engineered phospholipid or lysophospholipid (e.g., sphingosine 1-phosphate (S1P)) chaperone derived from an Apolipoprotein M (ApoM)-Fc fusion protein having an extended half life in vivo. The disclosed ApoM-Fc fusion protein provides a safe, efficient and effective means of delivering S1P to endothelial cells and to all tissues of the body.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: December 22, 2020
    Assignee: The Children's Medical Center Corporation
    Inventors: Timothy T. Hla, Steven L. Swendeman, Annarita DiLorenzo, Teresa Sanchez
  • APOM-FC FUSION PROTEINS, COMPLEXES THEREOF WITH SPHINGOSINE 1-PHOSPHATE (S1P), AND METHODS FOR TREATING VASCULAR AND NON-VASCULAR DISEASES
    Publication number: 20190185545
    Abstract: The present disclosure is directed to an engineered phospholipid or lysophospholipid (e.g., sphingosine 1-phosphate (S1P)) chaperone derived from an Apolipoprotein M (ApoM)-Fc fusion protein having an extended half life in vivo. The disclosed ApoM-Fc fusion protein provides a safe, efficient and effective means of delivering S1P to endothelial cells and to all tissues of the body.
    Type: Application
    Filed: August 15, 2017
    Publication date: June 20, 2019
    Applicant: Children's Medical Center Corporation
    Inventors: Timothy T. Hla, Steven L. Swendeman, Annarita DiLorenzo, Theresa Sanchez