Abstract: The present invention provides pathogen-inactivated red blood cell compositions.

Abstract: The present invention is based on the identification of a cohort of polyurethane block copolymers that are particularly suited for use in pharmaceutical polymeric drug-device units and which offer improved control of drug release. In particular, there is provided a polymeric drug-device unit comprising a polyurethane block copolymer obtainable by reacting together a poly(alkylene oxide); a difunctional compound; a difunctional isocyanate; and optionally a block copolymer comprising poly(alkylene oxide) blocks; and quinagolide as a pharmaceutically active agent. The drug-device units may find application in the treatment and/or prevention of endometriosis.

Abstract: The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ?3 destaurases, ?5 elongases and ?6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof (Formula (I)) in which m, X, R1, R2, R3 and R5 are as defined in the specification, processes for their preparation, pharmaceutical compositions N containing them and their use in therapy.

Abstract: The invention relates to a rotary shaft (23) for processing foodstuffs, wherein the rotary shaft (23) has a rotation axis and the rotary shaft comprises at least one tool (11). The at least one tool (11) extends along the rotation axis. The tool (11) further has an airfoil profile such that the tool comprises a leading edge, a trailing edge, an upper surface and a lower surface, wherein the leading edge and the trailing edge are different.

Abstract: Suspension of gas-filled microvesicles comprising a targeting ligand for binding to KDR or VEGF/KDR complex. The suspension is obtained by reconstituting a freeze-dried residue with a carbohydrate-containing solution in the presence of a physiologically acceptable gas and is stabilized by the presence of histidine.

Abstract: A diamine 2-(3,3,5-trimethylcyclohexyl)propane-1,3-diamine of formula 1 and a process for producing 2-(3,3,5-trimethylcyclohexyl)propane-1,3-diamine by A) reacting isophorone (IP) and malononitrile to afford the intermediate 2-(3,5,5-trimethylcyclohex-2-en-1-ylidene)malononitrile, and B) hydrogenating 2-(3,5,5-trimethylcyclohex-2-en-1-ylidene)malononitrile in the presence of at least one catalyst. In another embodiment, the hydrogenation in step B) of the process is performed at 20-120° C. and at 20-300 bar.

Abstract: An expandable threaded connection includes: first and second tubular components including respective male and female ends including respective first and second and third and fourth threaded zones, insertion regions, first and second annular tongues, prominent abutment faces, and first and second concavities; the first and second tongues are respectively engaged in the second and first concavities in a made up condition, the abutment face of at least one tongue in contact with at least one concavity; the male end including a first surface between the first threaded zone and the first tongue, and the female end including a second surface between the third threaded zone and the second concavity; in the made up condition, the first and second surfaces define an annular space include large and small radial dimension zones which, after expansion, can form a metal-metal contact seal, the first tongue bearing on the second tongue.

Abstract: The present invention provides a device for displaying hazard indicia, having a stanchion defining a first end and a second end, whereby the first end defines a first cross section that is smaller than a second cross section of the second end; a base adapted to removably receive the second end of the stanchion so as to maintain the stanchion in a vertical position; and a means for allowing the device to be collinearly stacked on top of a second device such that only the second end of the device and the second end of the second device contact.

Abstract: Displaying a comparison of genotypic information between relatives is disclosed, including receiving an indication that a first individual is a grandparent, receiving an indication that a second individual is a grandchild of the first individual, comparing the genotypic information of the first individual and the second individual and calculating a similarity score, and displaying an indication of the similarity score graphically using colors.

Abstract: The present invention relates to a bearing assembly that provides a magnetic sensor; a shaft; and a bearing. One of the shaft and the bearing is provided with a surface having a bearing steel and including a magnetic pattern disposed thereon for indicating a rotation of the shaft relative to the bearing. The magnetic pattern is provided by the microstructure of the surface; and the sensor is arranged to sense the pattern and output a signal indicative of a rotation of the shaft relative to the bearing.

Abstract: An illuminated light guide assembly includes a first light guide panel coupled to a first light source; a first light-extracting system on the first light guide panel; a second light guide panel coupled to a second light source different from the first light source; a second light-extracting system offset from the first extracting system; and a first optical isolator coupled to the first light guide panel with a first lamination interlayer and coupled to the second light guide panel with a second lamination interlayer.

Abstract: A system for metering flow of a fluid has a vibratable flowtube for receiving a multiphase fluid flow. A driver is configured to vibrate the flowtube. A pair of sensors is positioned to detect movement of the flowtube at different locations on the flowtube. Pressure and temperature sensors are positioned to measure a pressure of the fluid. One or more processors are configured to use a phase difference between the sensor signals to determine a fluid flow rate through the flowtube. The one or more processors are further configured to determine an amount of dissolved gas in the multiphase fluid using the pressure, the temperature, and the relative amounts the multiple liquids in the multiphase fluid.

Abstract: Body containment constructions, materials, and methods of use for bio-cremation processes are disclosed. Preferably, the containment constructions of the present invention provide the functionality of liquid containment and also the functionality of body presentment for viewing purposes, if desired, in addition to bio-degradability. Advantageously, liquid containment is provided in a body containment construction that is sufficiently liquid impervious, allows for body transport by sufficient structural support, and is decomposable within the time period for a bio-cremation process. More preferably, the containment construction will dissolve or decompose within a normal procedural time period without leaving any component remaining from the containment construction.

Abstract: The present invention relates to a cosmetic composition in the form of a nano- or micro-emulsion, comprising: (a) at least one oil; (b) at least one polyglyceryl fatty acid ester, preferably with a polyglyceryl moiety derived from 3 to 6 glycerins, and more preferably 5 or 6 glycerins; (c) at least one alkyl (poly)glucoside type surfactant; (d) at least one amphoteric surfactant; and (e) water. The cosmetic composition according to the present invention has a dispersed phase which has a smaller diameter due to a combination of the (b) polyglyceryl fatty acid ester and the (c) alkyl (poly)glucoside type surfactant, and the (d) amphoteric surfactant. Therefore, the cosmetic composition can be in the form of a nano- or micro-emulsion with a transparent or slightly translucent aspect.

Abstract: Peptide compounds based on the CAP37 (cationic antimicrobial protein of Mr 37 kDa) protein are disclosed, along with methods for treating various infections, wounds, and conditions, and methods of promoting healing and acceptance of grafts, using compositions containing these peptides.

Abstract: A time-of-flight (TOF) sensor device is configured to perform classification analytics on a waveform signal representing a reflected light pulse, and to classify an object from which the light pulse was received based on characteristic properties of the reflected pulse. The TOF sensor device can compare the reflected pulse waveform with stored characteristic waveform profiles indicative of different types of objects or atmospheric particulates, including but not limited to snow, aerosol, water, fog, or mist. Some embodiments of TOF sensor device can also detect excessive levels of mist or suspended particulates that may reduce the detection accuracy of the sensor. To this end, such embodiments project focused light beams according to a defined pattern, and compare the reflected pattern with the defined pattern to determine a degree of pattern distortion attributable to the presence of mist.

Abstract: A laminate comprising a first nonwoven layer comprising a plurality of apertures and a second nonwoven layer is provided. One of the first and second nonwoven layers is a pre-strained layer and is joined to the other one of the first and second nonwoven layers. The other one of the first and second nonwoven layers is a non-pre-strained layer. The pre-strained layer and the non-pre-strained layer together form a three-dimensional laminate.