Patents by Inventor Anne Arens

Anne Arens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Determination of in vivo DNA double-strand break localization and application thereof
    Patent number: 9493827
    Abstract: The present invention relates to a method for determining the in vivo localization of double-strand breaks in a host cell, comprising incubating a host cell suspected to comprise DNA double-strand breaks and a linear polynucleotide comprising a known sequence, detecting the in vivo insertion sites of said polynucleotide in the genome of said host cell, and assessing the in vivo localization of double-strand breaks. Further envisaged by the present invention is a method for obtaining an endonuclease with altered in vivo specificity. Finally, the present invention is directed to a kit for determining in vivo specificity of an endonuclease.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: November 15, 2016
    Assignees: Deutsches Krebsforschungszentrum, Ospedale San Raffaele SRL
    Inventors: Christof Von Kalle, Manfred Schmidt, Richard Gabriel, Ali Nowrouzi, Anne Arens, Angelo Lombardo, Luigi Naldini
  • DETERMINATION OF IN VIVO DNA DOUBLE-STRAND BREAK LOCALIZATION AND APPLICATION THEREOF
    Publication number: 20130143204
    Abstract: The present invention relates to a method for determining the in vivo localization of double-strand breaks in a host cell, comprising incubating a host cell suspected to comprise DNA double-strand breaks and a linear polynucleotide comprising a known sequence, detecting the in vivo insertion sites of said polynucleotide in the genome of said host cell, and assessing the in vivo localization of double-strand breaks. Further envisaged by the present invention is a method for obtaining an endonuclease with altered in vivo specificity. Finally, the present invention is directed to a kit for determining in vivo specificity of an endonuclease.
    Type: Application
    Filed: January 13, 2011
    Publication date: June 6, 2013
    Inventors: Christof Von Kalle, Manfred Schmidt, Richard Gabriel, Ali Nowrouzi, Anne Arens, Angelo Lombardo, Luigi Naldini