Patents by Inventor Anne B. Mason

Anne B. Mason has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant transferrins, transferrin half-molecules and mutants thereof
    Patent number: 8080640
    Abstract: Recombinant transferrin, non-glycosylated recombinant transferrin, transferrin half-molecules and mutant transferrins having altered metal-binding or other properties are described. The recombinant transferrin molecules are expressed in functional form by stable eukaryotic cell lines such as baby hamster kidney cells transformed with an expression vector encoding the recombinant molecule. The recombinant transferrins can be used in metal chelation therapy to bind and clear excess toxic metals in patients suffering from metal overloads or as tissue culture medium supplements or replacements.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: December 20, 2011
    Assignees: University of Vermont, The University of British Columbia
    Inventors: Walter D. Funk, Robert C. Woodworth, Anne B. Mason, Ross T. A. MacGillivray
  • CANCER DRUG DELIVERY USING MODIFIED TRANSFERRIN
    Publication number: 20110288023
    Abstract: The invention provides modified Transferrin (Tf) molecules and conjugates of the Tf molecules with a therapeutic agent. The invention also provides methods of treating cancer wherein the therapeutic agents are chemotherapeutic agents. The modified Tf molecules improve the delivery of the conjugated agent to a target tissue. In some embodiments, the modified Tf molecule has a mutation which decreases the release of bound iron from a Tf complex. The complex can also contain, for instance, a carbonate, oxalate, or other anion to stabilize the Tf iron complex.
    Type: Application
    Filed: December 6, 2010
    Publication date: November 24, 2011
    Applicants: The Regents of the University of California Office of Technology Transfer, Office of Technology Transfer, University of Vermont
    Inventors: Daniel T. Kamei, Bert J. Lao, Wen-Lin P. Tsai, Foad Mashayekhi, Edward A. Pham, Anne B. Mason
  • CANCER DRUG DELIVERY USING MODIFIED TRANSFERRIN
    Publication number: 20090181048
    Abstract: The present invention provides transferrin (Tf) conjugates of anti-cancer agents with increased cellular association and increased cellular internalization. The present invention also provides methods of treating cancer comprising administration of a Tf conjugate with increased cellular association to a subject with cancer. The present invention additionally provides methods of making, as well as screening for, Tf conjugates with increased cellular association or cellular internalization. The present invention also provides Tf conjugates with increased cellular association and internalization for delivering nucleic acids to cancer cells.
    Type: Application
    Filed: June 6, 2008
    Publication date: July 16, 2009
    Applicant: The Regents of the University of California
    Inventors: Daniel T. Kamei, Bert J. Lao, Wen-Lin P. Tsai, Foad Mashayekhi, Edward A. Pham, Anne B. Mason
  • Recombinant transferrins, transferrin half-molecules and mutants thereof
    Patent number: 6825037
    Abstract: Recombinant transferrin, non-glycosylated recombinant transferrin, transferrin half-molecules and mutant transferrins having altered metal-binding or other properties are described. The recombinant transferrin molecules are expressed in functional form by stable eukaryotic cell lines such as baby hamster kidney cells transformed with an expression vector encoding the recombinant molecule. The recombinant transferrins can be used in metal chelation therapy to bind and clear excess toxic metals in patients suffering from metal overloads or as tissue culture medium supplements or replacements.
    Type: Grant
    Filed: November 15, 1999
    Date of Patent: November 30, 2004
    Assignees: University of Vermont, University of British Columbia
    Inventors: Walter D. Funk, Ross T.A. MacGillivray, Anne B. Mason, Robert C. Woodworth
  • Recombinant transferrins, transferrin half-molecules and mutants thereof
    Patent number: 5986067
    Abstract: Recombinant transferrin, non-glycosylated recombinant transferrin, transferrin half-molecules and mutant transferrins having altered metal-binding or other properties are described. The recombinant transferrin molecules are expressed in functional form by stable eukaryotic cell lines such as baby hamster kidney cells transformed with an expression vector encoding the recombinant molecule. The recombinant transferrins can be used in metal chelation therapy to bind and clear excess toxic metals in patients suffering from metal overloads or as tissue culture medium supplements or replacements.
    Type: Grant
    Filed: December 28, 1993
    Date of Patent: November 16, 1999
    Assignees: The University of Vermont and State Agricultural College, The University of British Columbia
    Inventors: Walter D. Funk, Ross T. A. MacGillivray, Anne B. Mason, Robert C. Woodworth