Patents by Inventor Anne Chew

Anne Chew has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR TREATING CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)
    Publication number: 20230302052
    Abstract: The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes.
    Type: Application
    Filed: May 4, 2023
    Publication date: September 28, 2023
    Inventors: Carl H. June, Bruce L. Levine, Anne Chew, Stephen J. Schuster
  • Methods for treating chronic lymphocytic leukemia (CLL)
    Patent number: 11648270
    Abstract: The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: May 16, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Carl H. June, Bruce L. Levine, Anne Chew, Stephen J. Schuster
  • PROSTATE-SPECIFIC MEMBRANE ANTIGEN CARS AND METHODS OF USE THEREOF
    Publication number: 20210137980
    Abstract: The present disclosure provides modified immune cells (e.g., modified T cells) comprising a chimeric antigen receptor (CAR) having affinity for a prostate-specific membrane antigen (PSMA) (e.g., human PSMA). The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor. The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor, wherein the modified cell is capable of expressing and secreting a bispecific antibody.
    Type: Application
    Filed: March 5, 2020
    Publication date: May 13, 2021
    Inventors: Yangbing Zhao, Szu Hua Sharon Lin, Xiaojun Liu, Anne Chew
  • PROSTATE-SPECIFIC MEMBRANE ANTIGEN CARS AND METHODS OF USE THEREOF
    Publication number: 20200345778
    Abstract: The present disclosure provides modified immune cells (e.g., modified T cells) comprising a chimeric antigen receptor (CAR) having affinity for a prostate-specific membrane antigen (PSMA) (e.g., human PSMA). The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor. The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor, wherein the modified cell is capable of expressing and secreting a bispecific antibody.
    Type: Application
    Filed: July 20, 2020
    Publication date: November 5, 2020
    Inventors: Yangbing Zhao, Szu Hua Sharon Lin, Xiaojun Liu, Anne Chew
  • Prostate-specific membrane antigen cars and methods of use thereof
    Patent number: 10780120
    Abstract: The present disclosure provides modified immune cells (e.g., modified T cells) comprising a chimeric antigen receptor (CAR) having affinity for a prostate-specific membrane antigen (PSMA) (e.g., human PSMA). The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor. The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor, wherein the modified cell is capable of expressing and secreting a bispecific antibody.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: September 22, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Yangbing Zhao, Szu Hua Sharon Lin, Xiaojun Liu, Anne Chew
  • METHODS FOR TREATING CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)
    Publication number: 20190336530
    Abstract: The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes.
    Type: Application
    Filed: March 8, 2019
    Publication date: November 7, 2019
    Inventors: Carl H. June, Bruce L. Levine, Anne Chew, Stephen J. Schuster
  • PROSTATE-SPECIFIC MEMBRANE ANTIGEN CARS AND METHODS OF USE THEREOF
    Publication number: 20190275083
    Abstract: The present disclosure provides modified immune cells (e.g., modified T cells) comprising a chimeric antigen receptor (CAR) having affinity for a prostate-specific membrane antigen (PSMA) (e.g., human PSMA). The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor. The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor, wherein the modified cell is capable of expressing and secreting a bispecific antibody.
    Type: Application
    Filed: March 5, 2019
    Publication date: September 12, 2019
    Inventors: Yangbing Zhao, Szu Hua Sharon Lin, Xiaojun Liu, Anne Chew
  • Methods for treating chronic lymphocytic leukemia (CLL)
    Patent number: 10046008
    Abstract: The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: August 14, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Carl H. June, Bruce L. Levine, Anne Chew, Stephen J. Schuster
  • METHODS FOR TREATING CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)
    Publication number: 20160000829
    Abstract: The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes.
    Type: Application
    Filed: September 10, 2015
    Publication date: January 7, 2016
    Inventors: Carl H. June, Bruce L. Levine, Anne Chew, Stephen J. Schuster
  • Method for treating chronic lymphocytic leukemia (CC)
    Patent number: 9161971
    Abstract: The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: October 20, 2015
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Carl H. June, Bruce Levine, Anne Chew, Stephen J. Schuster
  • Methods for treating progressive multifocal leukoencephalopathy (PML)
    Patent number: 8415150
    Abstract: The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: April 9, 2013
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Carl H. June, Bruce Levine, Anne Chew, Stephen J. Schuster
  • Methods for Treating Progressive Multifocal Leukoencephalopathy (PML)
    Publication number: 20120263693
    Abstract: The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes.
    Type: Application
    Filed: June 29, 2012
    Publication date: October 18, 2012
    Inventors: Carl H. June, Bruce Levine, Anne Chew, Stephen J. Schuster
  • Methods for Treating Progressive Multifocal Leukoencephalopathy (PML)
    Publication number: 20120034249
    Abstract: The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes.
    Type: Application
    Filed: February 24, 2010
    Publication date: February 9, 2012
    Inventors: Carl H. June, Bruce Levine, Anne Chew, Stephen J. Schuster
  • Haplotypes of the FCER1A gene
    Publication number: 20050196829
    Abstract: Novel genetic variants of the Fc Fragment Of Ige, High Affinity I, Receptor For; Alpha Polypeptide (FCER1A) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the FCER1A gene. Compositions and methods for haplotyping and/or genotyping the FCER1A gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
    Type: Application
    Filed: February 11, 2002
    Publication date: September 8, 2005
    Inventors: Anne Chew, R. Denton, Amy Duda, Stefanie Kliem, Elizabeth Brown, Krishnan Nandabalan, J. Stephens
  • Haplotypes of the UCP2 gene
    Publication number: 20030207284
    Abstract: Novel genetic variants of the Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the UCP2 gene. Compositions and methods for haplotyping and/or genotyping the UCP2 gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
    Type: Application
    Filed: July 16, 2002
    Publication date: November 6, 2003
    Inventors: Anne Chew, R. Rex Denton, Christopher Raleigh Gilson, Krishnan Nandabalan, Katie E. Parks
  • Haplotypes of the TNFRSF11B gene
    Publication number: 20030175710
    Abstract: Novel genetic variants of the Tumor Necrosis Factor Receptor Superfamily, Member 11b (Osteoprotegerin) (TNFRSF11B) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the TNFRSF11B gene. Compositions and methods for haplotyping and/or genotyping the TNFRSF11B gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
    Type: Application
    Filed: January 9, 2002
    Publication date: September 18, 2003
    Inventors: Anne Chew, R. Rex Denton, Karyn M. Bieglecki, Krishnan Nandabalan, J. Claiborne Stephens
  • Haplotypes of the TNFRSF1A gene
    Publication number: 20030165844
    Abstract: Novel genetic variants of the Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the TNFRSF1A gene. Compositions and methods for haplotyping and/or genotyping the TNFRSF1A gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
    Type: Application
    Filed: August 31, 2001
    Publication date: September 4, 2003
    Applicant: Genaissance Pharmaceuticals, Inc.
    Inventors: Alison E. Anastasio, Anne Chew, R. Rex Denton, Krishnan Nandabalan, Katie E. Parks, J. Claiborne Stephens
  • Haplotypes of the icam2 gene
    Publication number: 20030082555
    Abstract: Novel genetic variants of the Intercellular Adhesion Molecule 2 (ICAM2) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the ICAM2 gene. Compositions and methods for haplotyping and/or genotyping the ICAM2 gene in an individual are also disclosed. Polynucleotides defined by the sequence the haplotypes disclosed herein are also described.
    Type: Application
    Filed: November 14, 2001
    Publication date: May 1, 2003
    Inventors: Anne Chew, Julie Y. Choi, R. Rex Denton, Stefanie E. Kliem, Helen H. Lee, Krishnan Nandabalan
  • Drug target isogenes: polymorphisms in the Interleukin 4 Receptor Alpha gene
    Publication number: 20030078220
    Abstract: Polynucleotides comprising one or more of 38 novel single nucleotide polymorphisms in the human Interleukin 4 Receptor Alpha(IL4R&agr;) gene are described. Compositions and methods for detecting one or more of these polymorphisms are also disclosed. In addition, various genotypes and haplotypes for IL4R&agr; gene that exist in the population are described.
    Type: Application
    Filed: November 9, 2001
    Publication date: April 24, 2003
    Inventors: Anne Chew, R. Rex Denton, Amy Duda, Krishnan Nandabalan, Joel Claiborne Stephens, Andreas K. Windemuth