Patents by Inventor Anne Frederica Grobler
Anne Frederica Grobler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200114007Abstract: A formulation and method for administration of at least one therapeutic mammalian protein to a mammal or a protein selected from the group, and for enhancing the absorption, distribution and release of the at least one therapeutic mammalian protein in or on the mammal, comprising at least one therapeutic mammalian protein in a micro-emulsion comprising a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous or other pharmacologically acceptable carrier in which nitrous oxide is dissolved, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids.Type: ApplicationFiled: December 13, 2019Publication date: April 16, 2020Applicant: North-West UniversityInventors: Jeanetta DU PLESSIS, Anne Frederica GROBLER, Abraham Frederik KOTZE
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Patent number: 10363324Abstract: This invention relates to a pharmaceutical composition for parenteral or oral administration containing a radioactive compound which can be used diagnostically or therapeutically. The composition comprises a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous or other pharmacologically acceptable carrier in which nitrous oxide is dissolved, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids, and the radioactive compound.Type: GrantFiled: November 4, 2014Date of Patent: July 30, 2019Assignees: The South African Nuclear Energy Corporation Limited, North-West UniversityInventors: Anne Frederica Grobler, Jan Rijn Zeevaart
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Patent number: 10321681Abstract: A plant supporting formulation which is also suitable for use as a delivery vehicle, or a component of a delivery vehicle, for the delivery of one or more phytologically beneficial substances to a plant, and for enhancing the translocation of such delivered substance(s) in or on the plant, the formulation comprising a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous carrier, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids. The dispersion is preferably characterized in that at least 50% of the vesicles or microsponges are of a diametrical size of between 50 nm and 5 micrometer. The dispersion is further also characterized in that the micro-emulsion has a zeta potential of between ?25 mV and ?60 mV.Type: GrantFiled: March 12, 2014Date of Patent: June 18, 2019Assignee: NORTH-WEST UNIVERSITYInventor: Anne Frederica Grobler
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Patent number: 10308929Abstract: This invention pertains to a method of preparing biological material from a biological sample selected from the group consisting of blood and sputum samples. The method includes the step of altering at least one constitutive characteristic of the biological sample in the presence of a capturing scaffold by adding a lysis buffer containing a solubilising agent and a detergent to the biological sample, for simultaneously inhibiting coagulation of the biological sample; lysing the biological sample to release the biological material from the biological sample, thus making the biological material available; and capturing at least one fraction of the biological material on the capturing scaffold.Type: GrantFiled: September 6, 2012Date of Patent: June 4, 2019Assignee: North-West UniversityInventors: Anne Frederica Grobler, Oksana Levanets
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Publication number: 20180296196Abstract: This invention relates to a method and device for collecting a Mycobacterium complex species, such Mycobacterium tuberculosis (MTB) from the oral cavities of particularly children and infants. A device is provided which has a distal end and an operative end portion manufactured from a parent polymer which has been functionalised with a chemical compound having an affinity to the Mycobacterium complex species to collect same such that the presence thereof in the sample can be detected. The invention further extends to a method of preparing biological material obtained from such collected sample.Type: ApplicationFiled: June 1, 2016Publication date: October 18, 2018Inventors: Anne Frederica GROBLER, Lizl CRONJE, Hendrik VILJOEN
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Patent number: 9585955Abstract: The invention provides for a method of enhancing immunological responses to an antigen in a vaccine formulation, and for a vaccine formulation that provides for an enhanced immunological response to an antigen. In the method and formulation the antigen is administered with an adjuvant which adjuvant comprises a solution of nitrous oxide gas in a pharmaceutically acceptable carrier solvent for the gas and which adjuvant includes at least one fatty acid or ester or other suitable derivative thereof selected from the group consisting of oleic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, arachidonic acid, eicosapentaenoic acid [C20: 5?3], decosahexaenoic acid [C22: 6?3], ricinoleic acid and derivatives thereof selected from the group consisting of the C1 to C6 alkyl esters thereof, the glycerol-polyethylene glycol esters thereof and the reaction product of hydrogenated natural oils composed largely of ricinoleic acid based oils, such as castor oil with ethylene oxide.Type: GrantFiled: November 8, 2013Date of Patent: March 7, 2017Assignee: North-West UniversityInventors: Anne Frederica Grobler, Abraham Frederik Kotze
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Publication number: 20160271279Abstract: This invention relates to a pharmaceutical composition for parenteral or oral administration containing a radioactive compound which can be used diagnostically or therapeutically. The composition comprises a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous or other pharmacologically acceptable carrier in which nitrous oxide is dissolved, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids, and the radioactive compound.Type: ApplicationFiled: November 4, 2014Publication date: September 22, 2016Inventors: Anne Frederica Grobler, Jan Rijn Zeevaart
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Publication number: 20140370508Abstract: This invention pertains to a method of preparing biological material from a biological sample selected from the group consisting of blood and sputum samples. The method includes the step of altering at least one constitutive characteristic of the biological sample in the presence of a capturing scaffold by adding a lysis buffer containing a solubilising agent and a detergent to the biological sample, for simultaneously inhibiting coagulation of the biological sample; lysing the biological sample to release the biological material from the biological sample, thus making the biological material available; and capturing at least one fraction of the biological material on the capturing scaffold.Type: ApplicationFiled: September 6, 2012Publication date: December 18, 2014Applicant: North-West UniversityInventors: Anne Frederica Grobler, Oksana Levanets
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Publication number: 20140255504Abstract: A formulation for administration of at least one therapeutic mammalian protein to a mammal or a protein selected from the group, and for enhancing the absorption, distribution and release of the at least one therapeutic mammalian protein in or on the mammal, comprising at least one therapeutic mammalian protein in a micro-emulsion comprising a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous or other pharmacologically acceptable carrier in which nitrous oxide is dissolved, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids. A method for effective delivery of at least one therapeutic mammalian protein to a mammal and for enhancing the therapeutic efficacy of such at least one therapeutic mammalian protein, comprising the step of administering the at least one therapeutic mammalian protein to the mammal in such a formulation.Type: ApplicationFiled: May 20, 2014Publication date: September 11, 2014Applicant: North-West UniversityInventors: Jeanetta DU PLESSIS, Anne Frederica GROBLER, Abraham Frederik KOTZE
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Publication number: 20140194288Abstract: A plant supporting formulation which is also suitable for use as a delivery vehicle, or a component of a delivery vehicle, for the delivery of one or more phytologically beneficial substances to a plant, and for enhancing the translocation of such delivered substance(s) in or on the plant, the formulation comprising a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous carrier, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids. The dispersion is preferably characterized in that at least 50% of the vesicles or microsponges are of a diametrical size of between 50 nm and 5 micrometer. The dispersion is further also characterized in that the micro-emulsion has a zeta potential of between ?25 mV and ?60 mV.Type: ApplicationFiled: March 12, 2014Publication date: July 10, 2014Applicant: NORTH-WEST UNIVERSITYInventor: Anne Frederica GROBLER
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Publication number: 20130344157Abstract: A formulation for administration of at least one therapeutic mammalian protein to a mammal or a protein selected from the group, and for enhancing the absorption, distribution and release of the at least one therapeutic mammalian protein in or on the mammal, comprising at least one therapeutic mammalian protein in a micro-emulsion comprising a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous or other pharmacologically acceptable carrier in which nitrous oxide is dissolved, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids. A method for effective delivery of at least one therapeutic mammalian protein to a mammal and for enhancing the therapeutic efficacy of such at least one therapeutic mammalian protein, comprising the step of administering the at least one therapeutic mammalian protein to the mammal in such a formulation.Type: ApplicationFiled: August 26, 2013Publication date: December 26, 2013Applicant: North-West UniversityInventors: Jeanetta DU PLESSIS, Anne Frederica GROBLER, Abraham Frederik KOTZE
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Publication number: 20120302442Abstract: A plant supporting formulation which is also suitable for use as a delivery vehicle, or a component of a delivery vehicle, for the delivery of one or more phytologically beneficial substances to a plant, and for enhancing the translocation of such delivered substance(s) in or on the plant, the formulation comprising a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous carrier, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids. The dispersion is preferably characterized in that at least 50% of the vesicles or microsponges are of a diametrical size of between 50 nm and 5 micrometer. The dispersion is further also characterized in that the micro-emulsion has a zeta potential of between ?25 mV and ?60 mV.Type: ApplicationFiled: April 6, 2012Publication date: November 29, 2012Applicant: NORTH-WEST UNIVERSITYInventor: Anne Frederica GROBLER
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Publication number: 20100297249Abstract: The invention provides a formulation for the administration of at least one therapeutic mammalian protein to a mammal, and for enhancing the absorption, distribution and release of the at least one therapeutic mammalian protein in or on the mammal, the formulation consisting of at least one therapeutic mammalian protein in a micro-emulsion which micro-emulsion is constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous or other pharmacologically acceptable earner in which nitrous oxide is dissolved, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids It further provides a method of the effective delivery of at least one therapeutic mammalian protein to a mammal and for enhancing the therapeutic efficacy of such at least one therapeutic mammalian protein, the method comprising the step of administering the at least one therapeutic mammaType: ApplicationFiled: July 5, 2007Publication date: November 25, 2010Applicant: NORTH-WEST UNIVERSITYInventors: Jeanetta Du Plessis, Anne Frederica Grobler, Abraham Frederik Kotze
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Publication number: 20090192040Abstract: The invention provides a plant supporting formulation which is also suitable for use as a delivery vehicle, or a component of a delivery vehicle, for the delivery of one or more phytologically beneficial substances to a plant, and for enhancing the translocation of such delivered substance(s) in or on the plant, the formulation comprising a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous carrier, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids. The dispersion is preferably characterized in that at least 50% of the vesicles or microsponges are of a diametrical size of between 50 nm and 5 micrometers.Type: ApplicationFiled: February 23, 2007Publication date: July 30, 2009Applicant: North-West UniversityInventor: Anne Frederica Grobler