Abstract: A multi-layered flexible sparger (100) that has a bottom film layer (102), a middle film layer (106), and a top film layer (110); a first inner mesh (104) disposed between the bottom film layer and the middle film layer; a second inner mesh (114) disposed between the middle film layer and the top film layer; and a port capable of delivering a gas to the multi-layered flexible sparger disposed between the top film layer and the bottom film layer, wherein the middle film layer comprises drill holes and the top film layer comprises drill holes.

Abstract: The present invention relates to compositions and methods for characterizing cancer. In particular, the present invention relates to compositions and methods for identifying bowel cancers at increased risk of metastasis.

Abstract: Methods, apparatus, systems, and articles of manufacture for training a neural network are disclosed. An example apparatus includes a training data segmenter to generate a partial set of labeled training data from a set of labeled training data. A matrix constructor is to create a design of experiments matrix identifying permutations of hyperparameters to be tested. A training controller is to cause a neural network trainer to train a neural network using a plurality of the permutations of hyperparameters in the design of experiments matrix and the partial set of labeled training data, and access results of the training corresponding of each of the permutations of hyperparameters. A result comparator is to select a permutation of hyperparameters based on the results, the training controller to instruct the neural network trainer to train the neural network using the selected permutation of hyperparameters and the labeled training data.

Abstract: A system for processing a biological fluid that includes a bioreactor, wherein the bioreactor includes a window, at least one port for allowing delivery of a processing aid; a control system, a sensor; a transmitter for transmitting the signal; a signal converter; a controller for receiving the signal; and a valve for delivering the processing aid to the port, wherein the sensor senses a process condition, transmits the signal, and the signal is compared with a reference signal and wherein a process action is optionally taken based on the comparison.

Abstract: A container, such as a disposable or single use bioreactor, optionally having one or more inlets and one or more outlets and a mixer associated with the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The container includes a flexible baffle shaped and positioned within the container to improve mixing, particularly to improve low shear mixing. The baffle is positioned within the container so as to disrupt the vortex formed by the mixer, or prevent formation of a vortex. The baffle is shaped with both horizontal and vertical elements to enhance disruption of the vortex across the entire vessel height and provide homogeneous mixing throughout all operating volumes. In certain embodiments, the baffle is X-shaped.

Abstract: The present invention relates to a process for producing nanocapsules employable as thermo latent polymerization catalysts, in particular for the polymerization of polyurethanes, by means of a high shear process, wherein the process comprises: (i) emulsifying a first reaction mixture (a) in a continuous aqueous phase comprising at least one stabilizer; (ii) emulsifying a second reaction mixture (b) in a continuous aqueous phase comprising at least one stabilizer; (iii) combining the first reaction to the nanocapsules produced by means of the described processes, to the use thereof, and to agents which contain these nanocapsules.

Abstract: Methods, apparatus, systems, and articles of manufacture for training a neural network are disclosed. An example apparatus includes a training data segmenter to generate a partial set of labeled training data from a set of labeled training data. A matrix constructor is to create a design of experiments matrix identifying permutations of hyperparameters to be tested. A training controller is to cause a neural network trainer to train a neural network using a plurality of the permutations of hyperparameters in the design of experiments matrix and the partial set of labeled training data, and access results of the training corresponding of each of the permutations of hyperparameters. A result comparator is to select a permutation of hyperparameters based on the results, the training controller to instruct the neural network trainer to train the neural network using the selected permutation of hyperparameters and the labeled training data.

Abstract: The invention relates to a method for producing special nanocapsules, which can be used as thermolatent polymerization catalysts, in particular for the polarization of polyurethanes, by means of a high shear process, wherein the method comprises: (i) emulsification of a reaction mixture into a continuous aqueous phase comprising at least one stabilizer, wherein the reaction mixture comprises, based on the total weight of the reaction mixture: (a) 10.0 to 99.0 wt. % of a monomer mixture which comprises, based on the total weight of the monomer mixture: (a1) 2.5 to 19.0 wt. % of at least one simply ethylenically unsaturated C3-5-carboxylic acid monomer; (a2) 76.0 to 97.5 wt. % of at least one simply ethylenically unsaturated C3-5-carboxylic acid-C1-10-alkyl ester monomer; (a3) 0.0 to 5.0 wt. % of at least one monomer which bears at least two ethylenically unsaturated groups; (b) 1.0 to 70.0 wt. % of at least one polymerization catalyst or initiator; (c) 0.0 to 89.0 wt.

Abstract: An aeration device, and containers or vessels incorporating the same. The aeration device can comprise a plurality of interchangeable aeration elements that can produce gas bubble of different sizes and deliver them to the contents of the container. Also disclosed are containers, such as a disposable or single-use container, optionally having one or more inlets and one or more outlets, an aeration device including a plurality of aeration elements, and a mixer to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The container can be a bioreactors and the aeration device controls the dissolved gas concentration content of the bioreactor contents, thereby facilitating proper growth of cell cultures in the bioreactor.

Abstract: A container, such as a disposable or single use bioreactor, optionally having one or more inlets and one or more outlets and a mixer associated with the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The container includes a flexible baffle shaped and positioned within the container to improve mixing, particularly to improve low shear mixing. The baffle is positioned within the container so as to disrupt the vortex formed by the mixer, or prevent formation of a vortex. The baffle is shaped with both horizontal and vertical elements to enhance disruption of the vortex across the entire vessel height and provide homogeneous mixing throughout all operating volumes. In certain embodiments, the baffle is X-shaped.

Abstract: The present invention relates to a method for determining or predicting the response of a patient diagnosed with locally advanced rectal cancer to chemoradiotherapy. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with rectal cancer to specific medicaments, radiotherapy and/or chemotherapy. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles in samples of said patients.

Abstract: The present invention relates to a method for determining or predicting the response of a patient diagnosed with locally advanced rectal cancer to chemoradiotherapy. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with rectal cancer to specific medicaments, radiotherapy and/or chemotherapy. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles in samples of said patients.

Abstract: An insulating facing tape material that can be used for covering exposed insulation surfaces to protect them from moisture and other environmental factors. The material typically includes a first layer of metal-containing foil, a second layer of metal-containing foil, a polymeric layer that is disposed between the first and second layers of metal-containing foil, and a pressure-sensitive adhesive connected to one of the layers of metal-containing foil and exposable for securing the tape material to a substrate. The polymeric layer is a laminate of multiple sub-layers of different principal polymer orientations. The pressure-sensitive adhesive layer may be covered with a release liner prior to application.