Patents by Inventor Anne Jefferson

Anne Jefferson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8507489
    Abstract: The present disclosure provides bicyclic triazole protein kinase modulators and methods of using these compounds to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: August 13, 2013
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: Pierre-Yves Bounaud, Christopher Ronald Smith, Elizabeth Anne Jefferson
  • Patent number: 8207173
    Abstract: Provided are compounds of the formula: wherein RN1 is a substituent of formula G1-NX1X2, wherein G1 is an optionally further substituted alkylene, which optionally forms, together with RN2, a cyclic group, and each of X1 and X2 is independently H or an N-substituent, or X1 and X2 together form a heterocyclic ring, or X1 together with G1 forms a cyclic group and X2 is H or an N-substituent; and each of Z1, Z2, Z3 and Z4 is H or a substituent, or two of Z1, Z2, Z3 and Z4 together form an optionally substituted ring, and further wherein at least one of Z1, Z2, Z3 and Z4 is other than H, and salts thereof, pharmaceutical compositions and methods of using the compounds. The compounds have antiviral activity.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: June 26, 2012
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Punit P. Seth, Elizabeth Anne Jefferson, Richard H. Griffey, Eric E. Swayze
  • Patent number: 8071581
    Abstract: The present disclosure relates to triazolopyridazine protein kinase modulators of Formula (I), methods of using these compounds to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: December 6, 2011
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: Christopher Ronald Smith, Pierre-Yves Bounaud, Elizabeth Anne Jefferson, Patrick S. Lee, Eduardo Torres
  • Publication number: 20100130513
    Abstract: Provided are compounds of the formula: wherein RN1 is a substituent of formula G1-NX1X2, wherein G1 is an optionally further substituted alkylene, which optionally forms, together with RN2, a cyclic group, and each of X1 and X2 is independently H or an N-substituent, or X1 and X2 together form a heterocyclic ring, or X1 together with G1 forms a cyclic group and X2 is H or an N-substituent; and each of Z1, Z2, Z3 and Z4 is H or a substituent, or two of Z1, Z2, Z3 and Z4 together form an optionally substituted ring, and further wherein at least one of Z1, Z2, Z3 and Z4 is other than H, and salts thereof, pharmaceutical compositions and methods of using the compounds. The compounds have antiviral activity.
    Type: Application
    Filed: November 17, 2009
    Publication date: May 27, 2010
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Punit P. Seth, Elizabeth Anne Jefferson, Richard H. Griffey, Eric E. Swayze
  • Publication number: 20100120739
    Abstract: The present disclosure relates to triazolopyridazine protein kinase modulators of Formula (I), methods of using these compounds to treat diseases mediated by kinase activity.
    Type: Application
    Filed: October 18, 2007
    Publication date: May 13, 2010
    Inventors: Christopher Ronald Smith, Pierre- Yves Bounaud, Elizabeth Anne Jefferson, Patrick S. Lee, Eduardo Torres
  • Patent number: 7642265
    Abstract: Provided are compounds of the formula: wherein RN1 is a substituent of formula G1—NX1X2, wherein G1 is an optionally further substituted alkylene, which optionally forms, together with RN2, a cyclic group, and each of X1 and X2 is independently H or an N-substituent, or X1 and X2 together form a heterocyclic ring, or X1 together with G1 forms a cyclic group and X2 is H or an N-substituent; and each of Z1, Z2, Z3 and Z4 is H or a substituent, or two of Z1, Z2, Z3 and Z4 together form an optionally substituted ring, and further wherein at least one of Z1, Z2, Z3 and Z4 is other than H, and salts thereof, pharmaceutical compositions and methods of using the compounds. The compounds have antiviral activity.
    Type: Grant
    Filed: September 22, 2004
    Date of Patent: January 5, 2010
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Punit P. Seth, Elizabeth Anne Jefferson, Richard H. Griffey, Eric E. Swayze
  • Publication number: 20090258855
    Abstract: The present disclosure provides bicyclic triazole protein kinase modulators and methods of using these compounds to treat diseases mediated by kinase activity.
    Type: Application
    Filed: October 18, 2007
    Publication date: October 15, 2009
    Inventors: Pierre-Yves Bounaud, Christopher Ronald Smith, Elizabeth Anne Jefferson
  • Publication number: 20090203132
    Abstract: The present invention provides pyrrolidinyl compounds that are useful for preparing conjugated oligomeric compounds. The conjugated pyrrolidinyl compounds can be attached to support medium and provide a free hydroxyl for oligomer synthesis to prepare an oligmeric compound having a 3?-conjugate. Alternatively, the pyrrolidinyl compound can be prepared as a phosphoramidite which can be placed internally or at the 5?-position of an oligomeric compound. These two strategies can be used together to prepare oligomeric compounds having 2 or more conjugates at any selected positions. The present invention also provides methods for modulating gene expression using the conjugated oligomeric compounds.
    Type: Application
    Filed: September 1, 2005
    Publication date: August 13, 2009
    Inventors: Eric E. Swayze, Dale E. Robinson, JR., Elizabeth Anne Jefferson, Prasad Dande, Thazha P. Prakash, Charles Allerson, Balkrishen Bhat
  • Patent number: 7432264
    Abstract: Provided are antibacterial biaryl compounds having micromolar MIC activity against Gram-negative and Gram-positive pathogens, including a methicillin-resistant S. aureus strain.
    Type: Grant
    Filed: August 9, 2004
    Date of Patent: October 7, 2008
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Elizabeth Anne Jefferson, Eric E. Swayze, Punit P. Seth, Dale E. Robinson, Jr.
  • Publication number: 20080008711
    Abstract: This invention relates to compositions and uses of NRG4, and to variants thereof and to polynucleotides encoding NRG4, for therapeutic and diagnostic purposes, particularly related to colon and pancreatic cancer. This invention also relates to therapeutic agents based on or derived from the polynucleotides and proteins, NRG4 inhibitors, particularly antibodies capable of specifically binding to NRG4.
    Type: Application
    Filed: April 18, 2007
    Publication date: January 10, 2008
    Inventors: Siew Schleyer, Anne Jefferson, Judith Abraham, W. Kavanaugh
  • Patent number: 7244847
    Abstract: The present invention is directed to novel benzimidazoles according to representative structures I and II, and their derivatives that possess antibacterial activity. This invention is also directed to compositions including the benzimidazole derivatives, and methods for using the same.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: July 17, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Eric E. Swayze, Yun He, Punit P. Seth, Elizabeth Anne Jefferson
  • Publication number: 20070148691
    Abstract: This invention relates to compositions and uses of NRG4, and to variants thereof and to polynucleotides encoding NRG4, for therapeutic and diagnostic purposes, particularly related to colon and pancreatic cancer. This invention also relates to therapeutic agents based on or derived from the polynucleotides and proteins, NRG4 inhibitors, particularly antibodies capable of specifically binding to NRG4.
    Type: Application
    Filed: February 9, 2007
    Publication date: June 28, 2007
    Inventors: Siew Schleyer, Anne Jefferson, Judith Abraham, W. Kavanaugh
  • Publication number: 20060089321
    Abstract: Inhibitors of human Cks1 and human Skp2, including antisense oligonucleotides, methods, and compositions specific for human Cks1 and human Skp2, are provided. Methods of using the compositions for modulating Cks1 expression and Skp2 expression, and for regulating cell growth, particularly tumor cell growth, are also provided.
    Type: Application
    Filed: February 12, 2003
    Publication date: April 27, 2006
    Inventors: Annette Walter, Christoph Reinhard, Anne Jefferson, Blanche-Marie Shamoon
  • Publication number: 20060062790
    Abstract: Inhibitors of human Akt3, including antisense oligonucleotides, methods, and compositions specific for human Akt3, are provided. Methods of using the compositions for modulating Akt3 expression and for regulating cell growth, particularly tumor cell growth, are also provided.
    Type: Application
    Filed: March 29, 2004
    Publication date: March 23, 2006
    Applicant: Chiron Corporation
    Inventors: Christoph Reinhard, Anne Jefferson
  • Publication number: 20060019912
    Abstract: Compositions incorporating small interfering ribonucleic acid (siRNA) and certain lipid-conjugated polyamide compound-based delivery vehicles that are particularly useful in the delivery siRNA and other polynucleotides to cells. Also, methods of making and using the compositions.
    Type: Application
    Filed: December 20, 2004
    Publication date: January 26, 2006
    Inventors: Timothy Burkoth, Anne Jefferson, Christoph Reinhard, Ronald Zuckermann
  • Publication number: 20050256121
    Abstract: The present invention relates to new substituted five-membered compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds.
    Type: Application
    Filed: March 30, 2005
    Publication date: November 17, 2005
    Applicant: Chiron Corporation
    Inventors: Anne Jefferson, Xiaodong Lin, Xiaojing Wang, Alice Rico, Annette Walter, Yasheen Zhou
  • Publication number: 20050130926
    Abstract: The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
    Type: Application
    Filed: October 28, 2004
    Publication date: June 16, 2005
    Inventors: Christoph Reinhard, Anne Jefferson, Vivien Chan, Joerg Kaufmann, Hong Xin, Giulia Kennedy, Greg Harrowe, Hamiduddin Khoja, Venkatakrishna Shyamala
  • Publication number: 20050063974
    Abstract: The present invention provides methods for identification of cancerous cells by detection of expression levels of TTK, as well as diagnostic, prognostic and therapeutic methods that take advantage of the differential expression of these genes in mammalian cancer. Such methods can be useful in determining the ability of a subject to respond to a particular therapy, e.g., as the basis of rational therapy. In addition, the invention provides assays for identifying pharmaceuticals that modulate activity of these genes in cancers in which these genes are involved, as well as methods of inhibiting tumor growth by inhibiting activity of TTK.
    Type: Application
    Filed: September 27, 2004
    Publication date: March 24, 2005
    Inventors: Christoph Reinhard, Anne Jefferson, Vivien Chan
  • Publication number: 20050058627
    Abstract: The present invention provides methods for identification of cancerous cells by detection of expression levels of TTK, as well as diagnostic, prognostic and therapeutic methods that take advantage of the differential expression of these genes in mammalian cancer. Such methods can be useful in determining the ability of a subject to respond to a particular therapy, e.g., as the basis of rational therapy. In addition, the invention provides assays for identifying pharmaceuticals that modulate activity of these genes in cancers in which these genes are involved, as well as methods of inhibiting tumor growth by inhibiting activity of TTK.
    Type: Application
    Filed: September 27, 2004
    Publication date: March 17, 2005
    Inventors: Christoph Reinhard, Anne Jefferson, Vivien Chan
  • Publication number: 20050059630
    Abstract: The present invention provides methods for identification of cancerous cells by detection of expression levels of TTK, as well as diagnostic, prognostic and therapeutic methods that take advantage of the differential expression of these genes in mammalian cancer. Such methods can be useful in determining the ability of a subject to respond to a particular therapy, e.g., as the basis of rational therapy. In addition, the invention provides assays for identifying pharmaceuticals that modulate activity of these genes in cancers in which these genes are involved, as well as methods of inhibiting tumor growth by inhibiting activity of TTK.
    Type: Application
    Filed: September 27, 2004
    Publication date: March 17, 2005
    Inventors: Christoph Reinhard, Anne Jefferson, Vivien Chan