Patents by Inventor Anne Kramer

Anne Kramer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric Antigen Receptor
    Publication number: 20230346838
    Abstract: The present invention provides a chimeric antigen receptor (CAR) comprising an antigen-binding domain with an affinity in the range of 50 nM to 500 nM, wherein said affinity comprises component kinetics such that the association rate constant (kon) is greater than or equal to 1×105 M?1 S?1, and/or the dissociation rate constant (koff) is greater than or equal to 0.01 s?1.
    Type: Application
    Filed: March 28, 2023
    Publication date: November 2, 2023
    Inventors: Martin Pulé, Anne Kramer, Evangelia K. Kokalaki
  • Chimeric Antigen Receptor (CAR) Comprising A CD19-Binding Domain
    Publication number: 20230220077
    Abstract: There is provided a chimeric antigen receptor (CAR) comprising a CD19-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1—GY-AFSSS (SEQ ID No. 1); CDR2—YPGDED (SEQ ID No. 2) CDR3—SLLYGDYLDY (SEQ ID No. 3); and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1—SASSSVSYMH (SEQ ID No. 4); CDR2—DTSKLAS (SEQ ID No. 5) CDR3—QQWNINPLT (SEQ ID No. 6). There is also provided a cell comprising such a CAR, and the use of such a cell in the treatment of cancer, in particular a B cell malignancy.
    Type: Application
    Filed: January 12, 2023
    Publication date: July 13, 2023
    Inventors: Martin Pulé, Leila Mekkaoui, Persis Amrolia, Sara Ghorashian, Anne Kramer, Gordon Cheung
  • Chimeric antigen receptor (CAR) comprising a CD19-binding domain
    Patent number: 11578126
    Abstract: There is provided a chimeric antigen receptor (CAR) comprising a CD19-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1—GY-AFSSS (SEQ ID No. 1); CDR2—YPGDED (SEQ ID No. 2) CDR3—SLLYGDYLDY (SEQ ID No. 3); and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1—SASSSVSYMH (SEQ ID No. 4); CDR2—DTSKLAS (SEQ ID No. 5) CDR3—QQWNINPLT (SEQ ID No. 6). There is also provided a cell comprising such a CAR, and the use of such a cell in the treatment of cancer, in particular a B cell malignancy.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: February 14, 2023
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Leila Mekkaoui, Persis Amrolia, Sara Ghorashian, Anne Kramer, Gordon Cheung
  • Device for an optical-fiber connection
    Patent number: 11385413
    Abstract: Device for the coaxial connection of fiber-optic cables, comprising a single-piece coupling housing (10) and a single-piece sleeve mount (20), the sleeve mount (20) being designed with at least one latching nose (21) and the coupling housing (10) being designed with at least one latching mount which complements the at least one latching nose (21), wherein the latching mount is designed with at least one latching hook (14) and at least one stop (15).
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: July 12, 2022
    Assignee: CommScope Technologies LLC
    Inventors: Eberhard Kahle, Anne Kramer, Jörg Adomeit
  • DEVICE FOR AN OPTICAL-FIBER CONNECTION
    Publication number: 20210239914
    Abstract: Device for the coaxial connection of fiber-optic cables, comprising a single-piece coupling housing (10) and a single-piece sleeve mount (20), the sleeve mount (20) being designed with at least one latching nose (21) and the coupling housing (10) being designed with at least one latching mount which complements the at least one latching nose (21), wherein the latching mount is designed with at least one latching hook (14) and at least one stop (15).
    Type: Application
    Filed: February 11, 2021
    Publication date: August 5, 2021
    Inventors: Eberhard Kahle, Anne Kramer, Jörg Adomeit
  • Device for an optical-fiber connection
    Patent number: 10948661
    Abstract: Device for the coaxial connection of fiber-optic cables, comprising a single-piece coupling housing (10) and a single-piece sleeve mount (20), the sleeve mount (20) being designed with at least one latching nose (21) and the coupling housing (10) being designed with at least one latching mount which complements the at least one latching nose (21), wherein the latching mount is designed with at least one latching hook (14) and at least one stop (15).
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: March 16, 2021
    Assignee: CommScope Technologies LLC
    Inventors: Eberhard Kahle, Anne Kramer, Jörg Adomeit
  • Chimeric Antigen Receptor
    Publication number: 20200254021
    Abstract: The present invention provides a chimeric antigen receptor (CAR) comprising an antigen-binding domain with an affinity in the range of 50 nM to 500 nM, wherein said affinity comprises component kinetics such that the association rate constant (kon) is greater than or equal to 1×105 M?1 S?1, and/or the dissociation rate constant (koff) is greater than or equal to 0.01 s?1.
    Type: Application
    Filed: February 20, 2020
    Publication date: August 13, 2020
    Inventors: Martin Pulé, Anne Kramer, Evangelia K. Kokalaki
  • CHIMERIC ANTIGEN RECEPTOR (CAR) COMPRISING A CD19-BINDING DOMAIN
    Publication number: 20200140544
    Abstract: There is provided a chimeric antigen receptor (CAR) comprising a CD19-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1—GY-AFSSS (SEQ ID No. 1); CDR2—YPGDED (SEQ ID No. 2) CDR3—SLLYGDYLDY (SEQ ID No. 3); and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1—SASSSVSYMH (SEQ ID No. 4); CDR2—DTSKLAS (SEQ ID No. 5) CDR3—QQWNINPLT (SEQ ID No. 6). There is also provided a cell comprising such a CAR, and the use of such a cell in the treatment of cancer, in particular a B cell malignancy.
    Type: Application
    Filed: September 17, 2019
    Publication date: May 7, 2020
    Inventors: Martin Pulé, Leila Mekkaoui, Persis Amrolia, Sara Ghorashian, Anne Kramer, Gordon Cheung
  • DEVICE FOR AN OPTICAL-FIBER CONNECTION
    Publication number: 20190391340
    Abstract: Device for the coaxial connection of fiber-optic cables, comprising a single-piece coupling housing (10) and a single-piece sleeve mount (20), the sleeve mount (20) being designed with at least one latching nose (21) and the coupling housing (10) being designed with at least one latching mount which complements the at least one latching nose (21), wherein the latching mount is designed with at least one latching hook (14) and at least one stop (15).
    Type: Application
    Filed: January 18, 2019
    Publication date: December 26, 2019
    Inventors: Eberhard Kahle, Anne Kramer, Jörg Adomeit
  • Chimeric antigen receptor (CAR) comprising a CD19-binding domain
    Patent number: 10457730
    Abstract: There is provided a chimeric antigen receptor (CAR) comprising a CD19-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1—GY-AFSSS (SEQ ID No. 1); CDR2—YPGDED (SEQ ID No. 2) CDR3—SLLYGDYLDY (SEQ ID No. 3); and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1—SASSSVSYMH (SEQ ID No. 4); CDR2—DTSKLAS (SEQ ID No. 5) CDR3—QQWNINPLT (SEQ ID No. 6). There is also provided a cell comprising such a CAR, and the use of such a cell in the treatment of cancer, in particular a B cell malignancy.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: October 29, 2019
    Assignee: UCL BUSINESS PLC
    Inventors: Martin Pulé, Leila Mekkaoui, Persis Amrolia, Sara Ghorashian, Anne Kramer, Gordon Cheung
  • Device for an optical-fiber connection
    Patent number: 10185095
    Abstract: Device for the coaxial connection of fiber-optic cables, comprising a single-piece coupling housing (10) and a single-piece sleeve mount (20), the sleeve mount (20) being designed with at least one latching nose (21) and the coupling housing (10) being designed with at least one latching mount which complements the at least one latching nose (21), wherein the latching mount is designed with at least one latching hook (14) and at least one stop (15).
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: January 22, 2019
    Assignee: CommScope Technologies LLC
    Inventors: Eberhard Kahle, Anne Kramer, Jörg Adomeit
  • DEVICE FOR AN OPTICAL-FIBER CONNECTION
    Publication number: 20180128985
    Abstract: Device for the coaxial connection of fiber-optic cables, comprising a single-piece coupling housing (10) and a single-piece sleeve mount (20), the sleeve mount (20) being designed with at least one latching nose (21) and the coupling housing (10) being designed with at least one latching mount which complements the at least one latching nose (21), wherein the latching mount is designed with at least one latching hook (14) and at least one stop (15).
    Type: Application
    Filed: August 14, 2017
    Publication date: May 10, 2018
    Inventors: Eberhard Kahle, Anne Kramer, Jörg Adomeit
  • CHIMERIC ANTIGEN RECEPTOR
    Publication number: 20180064758
    Abstract: The present invention provides a chimeric antigen receptor (CAR) comprising an antigen-binding domain with an affinity in the range of 50 nM to 500 nM, wherein said affinity comprises component kinetics such that the association rate constant (kon) is greater than or equal to 1×105 M?1 S?1, and/or the dissociation rate constant (koff) is greater than or equal to 0.01 s?1.
    Type: Application
    Filed: September 5, 2016
    Publication date: March 8, 2018
    Inventors: Martin Pulé, Anne Kramer, Evangelia K. Kokalaki
  • Chimeric Antigen Receptor (CAR) Comprising a CD19-Binding Domain
    Publication number: 20180044417
    Abstract: There is provided a chimeric antigen receptor (CAR) comprising a CD19-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1-GY-AFSSS (SEQ ID No. 1); CDR2-YPGDED (SEQ ID No. 2) CDR3-SLLYGDYLDY (SEQ ID No. 3); and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1-SASSSVSYMH (SEQ ID No. 4); CDR2-DTSKLAS (SEQ ID No. 5) CDR3-QQWNINPLT (SEQ ID No. 6). There is also provided a cell comprising such a CAR, and the use of such a cell in the treatment of cancer, in particular a B cell malignancy.
    Type: Application
    Filed: March 4, 2016
    Publication date: February 15, 2018
    Inventors: Martin Pulé, Leila Mekkaoui, Persis Amrolia, Sara Ghorashian, Anne Kramer, Gordon Cheung
  • Device for an optical-fiber connection
    Patent number: 9733434
    Abstract: Device for the coaxial connection of fiber-optic cables, comprising a single-piece coupling housing (10) and a single-piece sleeve mount (20), the sleeve mount (20) being designed with at least one latching nose (21) and the coupling housing (10) being designed with at least one latching mount which complements the at least one latching nose (21), wherein the latching mount is designed with at least one latching hook (14) and at least one stop (15).
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: August 15, 2017
    Assignee: CommScope Technologies LLC
    Inventors: Eberhard Kahle, Anne Kramer, Jörg Adomeit
  • DEVICE FOR AN OPTICAL-FIBER CONNECTION
    Publication number: 20170023745
    Abstract: Device for the coaxial connection of fiber-optic cables, comprising a single-piece coupling housing (10) and a single-piece sleeve mount (20), the sleeve mount (20) being designed with at least one latching nose (21) and the coupling housing (10) being designed with at least one latching mount which complements the at least one latching nose (21), wherein the latching mount is designed with at least one latching hook (14) and at least one stop (15).
    Type: Application
    Filed: June 27, 2016
    Publication date: January 26, 2017
    Inventors: Eberhard Kahle, Anne Kramer, Jörg Adomeit
  • Device for an optical-fiber connection
    Patent number: 9377590
    Abstract: Device for the coaxial connection of fiber-optic cables, comprising a single-piece coupling housing (10) and a single-piece sleeve mount (20), the sleeve mount (20) being designed with at least one latching nose (21) and the coupling housing (10) being designed with at least one latching mount which complements the at least one latching nose (21), wherein the latching mount is designed with at least one latching hook (14) and at least one stop (15).
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: June 28, 2016
    Assignee: CommScope Technologies LLC
    Inventors: Eberhard Kahle, Anne Kramer, Jörg Adomeit
  • DEVICE FOR AN OPTICAL-FIBER CONNECTION
    Publication number: 20150316729
    Abstract: Device for the coaxial connection of fiber-optic cables, comprising a single-piece coupling housing (10) and a single-piece sleeve mount (20), the sleeve mount (20) being designed with at least one latching nose (21) and the coupling housing (10) being designed with at least one latching mount which complements the at least one latching nose (21), wherein the latching mount is designed with at least one latching hook (14) and at least one stop (15).
    Type: Application
    Filed: March 4, 2015
    Publication date: November 5, 2015
    Inventors: Eberhard Kahle, Anne Kramer, Jörg Adomeit
  • Device for an optical-fiber connection
    Patent number: 8985861
    Abstract: Device for the coaxial connection of fiber-optic cables, comprising a single-piece coupling housing (10) and a single-piece sleeve mount (20), the sleeve mount (20) being designed with at least one latching nose (21) and the coupling housing (10) being designed with at least one latching mount which complements the at least one latching nose (21), wherein the latching mount is designed with at least one latching hook (14) and at least one stop (15).
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: March 24, 2015
    Assignee: ADC GmbH
    Inventors: Eberhard Kahle, Anne Kramer, Jörg Adomeit
  • Fibre-optic telecommunications module
    Patent number: 8958679
    Abstract: The invention relates to a fiber optic telecommunications module (100) comprising: a main housing portion (102) including a top wall (108), a bottom wall (110), a first transverse sidewall (106), a rear wall (112), an open front end (120), and an open second side (116), the main housing portion (102) including an optical component (130); a cover portion (104, 104a) coupled to the main housing portion (102) to close up the open second side (116) of the main housing portion (102) and keep the optical component (130) within the main housing portion (102); a first fiber optic adapter module (316) and a second fiber optic adapter module (316) removably coupled to the main housing portion (102) to close the open front end (120) of the main housing portion (102), the first and second fiber optic adapter modules (316) being provided in a stacked arrangement in a direction extending from the first transverse (106) sidewall toward the cover portion (104, 104a); wherein each of the first and second fiber optic adapter m
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: February 17, 2015
    Assignee: Tyco Electronics Services GmbH
    Inventors: Anne Kramer, Bartolomej Krupansky