Patents by Inventor Anne Lassus

Anne Lassus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted gas-filled microvesicles formulation
    Patent number: 12070512
    Abstract: Suspension of gas-filled microvesicles comprising a targeting ligand for binding to KDR or VEGF/KDR complex. The suspension is obtained by reconstituting a freeze-dried residue with a carbohydrate-containing solution in the presence of a physiologically acceptable gas and is stabilized by the presence of histidine.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: August 27, 2024
    Assignee: Bracco Suisse SA
    Inventors: Philippe Bussat, Anne Lassus
  • CATIONIC CALIBRATED-SIZE GAS-FILLED MICROVESICLES
    Publication number: 20240277866
    Abstract: The invention relates to new calibrated-size gas-filled microvesicles bearing an overall positive charge, to their use and to their method of manufacturing. The gas-filled microvesicles have a geometric standard deviation (GSD) value of at least 1.25 or lower and a stabilizing envelope comprising an amphiphilic material, said amphiphilic material comprising a cationic lipid and a neutral or cationic amphiphilic polymeric compound.
    Type: Application
    Filed: July 14, 2022
    Publication date: August 22, 2024
    Applicant: Bracco Suisse SA
    Inventors: Anne LASSUS, Samir CHERKAOUI
  • FREEZE-DRIED PRODUCT AND GAS-FILLED MICROVESICLES SUSPENSION
    Publication number: 20230414517
    Abstract: A method of manufacturing a suspension of gas-filled microvesicles by reconstituting a freeze-dried product and a suspension obtained according to said method, where the freeze-dried product has been subjected to a thermal treatment
    Type: Application
    Filed: June 26, 2023
    Publication date: December 28, 2023
    Applicant: Bracco Suisse SA
    Inventors: Philippe Bussat, Anne LASSUS, Jean BROCHOT, Michel SCHNEIDER, Feng YAN
  • Preparation of size-controlled microvesicles
    Patent number: 11752222
    Abstract: A method for preparing a suspension of “size-controlled” gas-filled microvesicles by microfluidic manufacturing techniques, which comprises using a gaseous flow comprising a first gas having high solubility in water and a second gas having low 5 solubility in water.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: September 12, 2023
    Assignee: Bracco Suisse SA
    Inventors: Tim Segers, Emmanuel Gaud, Gilles Casqueiro, Peter Frinking, Anne Lassus
  • Freeze-dried product and gas-filled microvesicles suspension
    Patent number: 11723869
    Abstract: A method of manufacturing a suspension of gas-filled microvesicles by reconstituting a freeze-dried product and a suspension obtained according to said method, where the freeze-dried product has been subjected to a thermal treatment.
    Type: Grant
    Filed: July 25, 2022
    Date of Patent: August 15, 2023
    Assignee: Bracco Suisse SA
    Inventors: Philippe Bussat, Anne Lassus, Jean Brochot, Michel Schneider, Feng Yan
  • FREEZE-DRIED COMPOSITION FOR PREPARING CALIBRATED GAS-FILLED MICROVESICLES
    Publication number: 20220409749
    Abstract: The present invention generally relates to the field of ultrasound contrast-agents (USCA). In particular, it relates to a freeze-dried composition comprising an amphiphilic material and a mixture of freeze-drying protecting components, which may be reconstituted for preparing a suspension of gas-filled microvesicles with calibrated size, useful in diagnostic or therapeutic applications. It further relates to the method for the preparation of such freeze-dried composition.
    Type: Application
    Filed: June 24, 2020
    Publication date: December 29, 2022
    Applicant: Bracco Suisse SA
    Inventors: Anne LASSUS, Samir CHERKAOUI
  • FREEZE-DRIED PRODUCT AND GAS-FILLED MICROVESICLES SUSPENSION
    Publication number: 20220354795
    Abstract: A method of manufacturing a suspension of gas-filled microvesicles by reconstituting a freeze-dried product and a suspension obtained according to said method, where the freeze-dried product has been subjected to a thermal treatment
    Type: Application
    Filed: July 25, 2022
    Publication date: November 10, 2022
    Applicant: Bracco Suisse SA
    Inventors: Philippe Bussat, Anne LASSUS, Jean BROCHOT, Michel SCHNEIDER, Feng YAN
  • FREEZE-DRIED COMPOSITION FOR PREPARING CALIBRATED GAS-FILLED MICROVESICLES
    Publication number: 20220339301
    Abstract: The present invention generally relates to the field of ultrasound contrast-agents (USCA). In particular, it relates to a freeze-dried composition comprising an amphiphilic material and a freeze-drying protecting component, which may be reconstituted for preparing a suspension of gas-filled microvesicles with calibrated size, useful in diagnostic or therapeutic applications. It further relates to the method for the preparation of such freeze-dried composition.
    Type: Application
    Filed: June 24, 2020
    Publication date: October 27, 2022
    Applicant: Bracco Suisse SA
    Inventors: Anne LASSUS, Samir CHERKAOUI
  • Freeze-dried product and gas-filled microvesicles suspension
    Patent number: 11426352
    Abstract: A method of manufacturing a suspension of gas-filled microvesicles by reconstituting a freeze-dried product and a suspension obtained according to said method, where the freeze-dried product has been subjected to a thermal treatment.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: August 30, 2022
    Assignee: BRACCO SUISSE SA
    Inventors: Philippe Bussat, Anne Lassus, Jean Brochot, Michel Schneider, Feng Yan
  • FREEZE-DRIED PRODUCT AND GAS-FILLED MICROVESICLES SUSPENSION
    Publication number: 20220202719
    Abstract: A method of manufacturing a suspension of gas-filled microvesicles by reconstituting a freeze-dried product and a suspension obtained according to said method, where the freeze-dried product has been subjected to a thermal treatment
    Type: Application
    Filed: May 14, 2020
    Publication date: June 30, 2022
    Inventors: Philippe Bussat, Anne LASSUS, Jean BROCHOT, Michel SCHNEIDER, Feng YAN
  • TARGETED GAS-FILLED MICROVESICLES FORMULATION
    Publication number: 20210386872
    Abstract: Suspension of gas-filled microvesicles comprising a targeting ligand for binding to KDR or VEGF/KDR complex. The suspension is obtained by reconstituting a freeze-dried residue with a carbohydrate-containing solution in the presence of a physiologically acceptable gas and is stabilized by the presence of histidine.
    Type: Application
    Filed: June 21, 2021
    Publication date: December 16, 2021
    Applicant: Bracco Suisse SA
    Inventors: Philippe BUSSAT, Anne LASSUS
  • Targeted gas-filled microvesicles formulation
    Patent number: 11071792
    Abstract: Suspension of gas-filled microvesicles comprising a targeting ligand for binding to KDR or VEGF/KDR complex. The suspension is obtained by reconstituting a freeze-dried residue with a carbohydrate-containing solution in the presence of a physiologically acceptable gas and is stabilized by the presence of histidine.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: July 27, 2021
    Assignee: Braceo Suisse SA
    Inventors: Philippe Bussat, Anne Lassus
  • Preparation of size-controlled microparticles
    Patent number: 10918605
    Abstract: A method for preparing a suspension of size-controlled microparticles stabilized by a layer of amphiphilic material. The method, which may be applied to preparations using microfluidic techniques, comprises controlling the temperature of the microparticles during the preparation process and preferably while collecting the formed microparticles.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: February 16, 2021
    Assignee: Bracco Suisse SA
    Inventors: Tim Segers, Peter Frinking, Anne Lassus, Philippe Bussat, Emmanuel Gaud, Samir Cherkaoui
  • PREPARATION OF SIZE-CONTROLLED MICROVESICLES
    Publication number: 20210000984
    Abstract: A method for preparing a suspension of “size-controlled” gas-filled microvesicles by microfluidic manufacturing techniques, which comprises using a gaseous flow comprising a first gas having high solubility in water and a second gas having low 5 solubility in water.
    Type: Application
    Filed: March 4, 2019
    Publication date: January 7, 2021
    Applicant: Bracco Suisse SA
    Inventors: Tim SEGERS, Emmanuel GAUD, Gilles CASQUEIRO, Peter FRINKING, Anne LASSUS
  • FREEZE-DRIED PRODUCT AND GAS-FILLED MICROVESICLES SUSPENSION
    Publication number: 20200360540
    Abstract: A method of manufacturing a suspension of gas-filled microvesicles by reconstituting a freeze-dried product and a suspension obtained according to said method, where the freeze-dried product has been subjected to a thermal treatment.
    Type: Application
    Filed: November 19, 2019
    Publication date: November 19, 2020
    Inventors: Anne LASSUS, Michel SCHNEIDER, Feng YAN, Philippe Bussat, Jean BROCHOT
  • TARGETED GAS-FILLED MICROVESICLES FORMULATION
    Publication number: 20200330620
    Abstract: Suspension of gas-filled microvesicles comprising a targeting ligand for binding to KDR or VEGF/KDR complex. The suspension is obtained by reconstituting a freeze-dried residue with a carbohydrate-containing solution in the presence of a physiologically acceptable gas and is stabilized by the presence of histidine.
    Type: Application
    Filed: May 6, 2020
    Publication date: October 22, 2020
    Applicant: Bracco Suisse SA
    Inventors: Philippe BUSSAT, Anne LASSUS
  • Targeted gas-filled microvesicles formulation
    Patent number: 10682429
    Abstract: Suspension of gas-filled microvesicles comprising a targeting ligand for binding to KDR or VEGF/KDR complex. The suspension is obtained by reconstituting a freeze-dried residue with a carbohydrate-containing solution in the presence of a physiologically acceptable gas and is stabilized by the presence of histidine.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: June 16, 2020
    Assignee: BRACCO SUISSE S.A.
    Inventors: Philippe Bussat, Anne Lassus
  • Gas-filled microvesicles for use as vaccine
    Patent number: 10537622
    Abstract: Gas-filled microvesicles comprising an antigen bound thereto and to aqueous suspensions containing said microvesicles, for use in immunomodulating formulations, in particular as a vaccine. The antigen is covalently bound to a component of the microvesicles envelope. The microvesicles of the invention, comprising a molar excess of fatty acids in the stabilizing envelope, are particularly effective in the uptake by antigen-presenting cells, in particular dendritic cells.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: January 21, 2020
    Assignee: BRACCO SUISSE S.A.
    Inventors: Gilles Bioley, Philippe Bussat, Blaise Corthesy, Anne Lassus
  • Freeze-dried formulation for gas-filled microvesicles
    Patent number: 10335502
    Abstract: A freeze-dried powder composition comprising a phospholipid and a polyethylene glycol, said polyethylene glycol having a percentage of folded polymeric chains of 40% or higher. The composition is suitable for preparing gas-filled microvesicles.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: July 2, 2019
    Assignee: Bracco Suisse SA
    Inventors: Anne Lassus, Stéphane Gorgerat, Feng Yan, Christian Guillot, Jean Brochot
  • PREPARATION OF SIZE-CONTROLLED MICROPARTICLES
    Publication number: 20190175516
    Abstract: A method for preparing a suspension of size-controlled microparticles stabilized by a layer of amphiphilic material. The method, which may be applied to preparations using microfluidic techniques, comprises controlling the temperature of the microparticles during the preparation process and preferably while collecting the formed microparticles.
    Type: Application
    Filed: August 30, 2017
    Publication date: June 13, 2019
    Applicant: Bracco Suisse SA
    Inventors: Tim SEGERS, Peter FRINKING, Anne LASSUS, Philippe BUSSAT, Emmanuel GAUD, Samir CHERKAOUI