Patents by Inventor Anne Laure Grillot

Anne Laure Grillot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gyrase inhibitors and uses thereof
    Patent number: 6930116
    Abstract: The present invention relates to compounds of the formula I: where Ring A is a thiazole, oxazole, imidazole or pyrazole and the substituents are as described in the specification, and pharmaceutically acceptable salts thereof. The compounds inhibit bacterial gyrase activity and therefore are useful for treating bacterial infections in mammals.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: August 16, 2005
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Paul Charifson, Dean Stamos, Michael Badia, Anne Laure Grillot, Steven Ronkin, Martin Trudeau
  • Gyrase inhibitors and uses thereof
    Publication number: 20050038247
    Abstract: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
    Type: Application
    Filed: July 29, 2004
    Publication date: February 17, 2005
    Inventors: Paul Charifson, David Deininger, Anne-Laure Grillot, Yusheng Liao, Steven Ronkin, Dean Stamos, Emanuele Perola, Tiansheng Wang, Arnaud LeTiran, Joseph Drumm
  • Inhibitors of c-jun N terminal kinases (JNK) and other protein kinases
    Publication number: 20050026967
    Abstract: The present invention provides compounds of formula I: where R1 is H, CONH2, T(n)—R, or T(n)—Ar2, n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Application
    Filed: February 13, 2004
    Publication date: February 3, 2005
    Inventors: Jeremy Green, Guy Bemis, Anne-Laure Grillot, Mark Ledeboer, Francesco Salituro, Edmund Harrington, Huai Gao, Christopher Baker, Jingrong Cao, Michael Hale
  • Gyrase inhibitors and uses thereof
    Publication number: 20040235886
    Abstract: The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
    Type: Application
    Filed: January 29, 2004
    Publication date: November 25, 2004
    Inventors: Paul S. Charifson, David D. Deininger, Anne-Laure Grillot, Yusheng Liao, Steven M. Ronkin, Dean Stamos, Emanuele Perola, Tiansheng Wang, Arnaud LeTiran, Joseph Drumm
  • Gyrase inhibitors and uses thereof
    Publication number: 20040043989
    Abstract: The present invention relates to compounds of the formula I: 1
    Type: Application
    Filed: May 23, 2003
    Publication date: March 4, 2004
    Inventors: Anne-Laure Grillot, Paul Charifson, Dean Stamos, Yusheng Liao, Michael Badia, Martin Trudeau
  • Inhibitors of c-JUN N terminal kinases (JNK) and other protein kinases
    Patent number: 6693108
    Abstract: The present invention provides compounds of formula I: where R1 is H, CONH2, T(n)—R, or T(n)—Ar2, n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: February 17, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jeremy Green, Guy Bemis, Anne-Laure Grillot, Mark Ledeboer, Francesco G. Salituro, Edmund Harrington, Huai Gao, Christopher Baker, Jingrong Cao, Michael Hale
  • Gyrase inhibitors and uses thereof
    Publication number: 20040024030
    Abstract: The present invention relates to compounds of the formula I: 1
    Type: Application
    Filed: March 24, 2003
    Publication date: February 5, 2004
    Inventors: Paul Charifson, Dean Stamos, Michael Badia, Anne Laure Grillot, Steven Ronkin, Martin Trudeau
  • Inhibitors of caspases
    Publication number: 20030232986
    Abstract: The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1&bgr; converting enzyme (“ICE”) inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase activity and consequently, may be advantageously used as agents against interleukin-1-(“IL-1”) , apoptosis-, interferon-&ggr; inducing factor-(IGIF), or interferon-&ggr;-(“IFN-&ggr;”) mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases.
    Type: Application
    Filed: December 6, 2002
    Publication date: December 18, 2003
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Marion M. Wannamaker, Guy W. Bemis, Paul S. Charifson, David J. Lauffer, Michael D. Mullican, Mark A. Murcko, Keith P. Wilson, James W. Janetka, Robert J. Davies, Anne-Laure Grillot, Zhan Shi, Cornelia J. Forster
  • Gyrase inhibitors and uses thereof
    Patent number: 6632809
    Abstract: The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammala. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: October 14, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Anne-Laure Grillot, Paul Charifson, Dean Stamos, Yusheng Liao, Michael Badia, Martin Trudeau
  • Gyrase inhibitors and uses thereof
    Publication number: 20030170858
    Abstract: Disclosed herein are compounds comprising the pharmacophore features HBA, HBD, Grp1, and at least two features selected from Grp2, Grp3 or Grp4: 1
    Type: Application
    Filed: July 18, 2002
    Publication date: September 11, 2003
    Inventors: Paul Charifson, Steve Bellon, Dean Stamos, Michael Badia, Anne-Laure Grillot, Steven Ronkin, Mark Murcko, Martin Trudeau
  • Gyrase inhibitors and uses thereof
    Patent number: 6608087
    Abstract: The present invention relates to compounds of the formula I: where Ring A is a thiazole, oxazole, imidazole or pyrazole and the substituents are as described in the specification, and pharmaceutically acceptable salts thereof. The compounds inhibit bacterial gyrase activity and therefore are useful for treating bacterial infections in mammals.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: August 19, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Paul Charifson, Dean Stamos, Michael Badia, Anne-Laure Grillot, Steven Ronkin, Martin Trudeau
  • Inhibitors of c-Jun N terminal kinases (JNK) and other protein kinases
    Publication number: 20030149051
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: February 12, 2002
    Publication date: August 7, 2003
    Inventors: Jeremy Green, Guy Bemis, Anne-Laure Grillot, Mark Ledeboer, Francesco G. Salituro, Edmund Harrington, Huai Gao, Christopher Baker, Jingrong Cao, Michael Hale
  • Gyrase inhibitors and uses thereof
    Publication number: 20030119868
    Abstract: The present invention relates to compounds of the formula I: 1
    Type: Application
    Filed: December 12, 2001
    Publication date: June 26, 2003
    Inventors: Anne-Laure Grillot, Paul Charifson, Dean Stamos, Yusheng Liao, Michael Badia, Martin Trudeau
  • Inhibitors of caspases
    Patent number: 6531474
    Abstract: The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1&bgr; converting enzyme (“ICE”) inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase activity and consequently, may be advantageously used as agents against interleukin-1-(“IL-1”), apoptosis-, interferon-&ggr; inducing factor-(IGIF), or interferon-&ggr;-(“IFN-&ggr;”) mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: March 11, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Marion W. Wannamaker, Guy W. Bemis, Paul S. Charifson, David J. Lauffer, Michael D. Mullican, Mark A. Murcko, Keith P. Wilson, James W. Janetka, Robert J. Davies, Anne-Laure Grillot, Zhan Shi, Cornelia J. Forster