Abstract: Methods of controlling processes having operating conditions, one or more inputs, and one or more outputs. The methods comprise defining acceptable steady state conditions, operating the process, and sampling output on the basis of a dual segment output population model, detecting destabilizing process events which result in output not representing acceptable output parameters, defining operating conditions according to which output is rejected, and defining output parameters according to which output is rejected. Upon detecting a destabilizing process event, the invention temporarily implements sampling assuming a second segment of the output population.