Patents by Inventor Anne Mary Freeman

Anne Mary Freeman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation and use of sialylated glycoforms of soluble complement receptor 1 (CR1)
    Patent number: 6057131
    Abstract: Provided are methods of making preparations of recombinant soluble Complement Receptor type 1 (sCR1) defined with respect to the distribution of sCR1 glycoforms and therapeutic methods using them. The preparations are suitable for treatment of allograft or xenograft rejection, diseases involving inflammation or inappropriate complement activation, and thrombotic or shock state conditions. Preferred methods employ sCR1 glycoforms that are sialylated, have a pI of .ltoreq.5.1, or have a sialic acid: mannose molar ratio of .gtoreq.0.25.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: May 2, 2000
    Assignee: Avant Immunotherapeutics, Inc.
    Inventors: Henry C. Marsh, Jr., Richard A. G. Smith, Chang-Jing Grace Yeh, John Lifter, Anne Mary Freeman, Michael L. Gosselin
  • Therapeutic methods employing sialylated glycoforms of soluble complement receptor 1 (SCR 1)
    Patent number: 5858969
    Abstract: Provided are therapeutic methods employing preparations of recombinant soluble Complement Receptor type 1 (sCR1) defined with respect to the distribution of sCR1 glycoforms. The methods are suitable for treatment of disease involving inflammation, inappropriate complement activation, and in thrombotic or shock state conditions. Preferred methods employ sCR1 glycoforms that are sialylated, have a pI of .ltoreq.5.1, or have a sialic acid:mannose molar ratio of .gtoreq.0.25.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 12, 1999
    Assignee: T Cell Sciences, Inc.
    Inventors: Henry C. Marsh, Jr., Richard A.G. Smith, Chang-Jing Grace Yeh, John Lifter, Anne Mary Freeman, Michael L. Gosselin
  • Soluble CR1 derivatives
    Patent number: 5859223
    Abstract: Soluble polypeptides are provided that comprise no more than three short consensus repeats (SCR) of Complement Receptor 1, and contain SCR3. DNA molecules encoding such soluble polypeptides, as well as methods, vectors and host cells, also are provided.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: January 12, 1999
    Assignee: AdProTech Plc
    Inventors: Danuta Ewa Irena Mossakowska, Ian Dodd, Anne Mary Freeman, Richard Anthony Godwin Smith
  • Soluble CR1 derivatives
    Patent number: 5833989
    Abstract: A soluble polypeptide comprising, in sequence, one to four short consensus repeats (SCR) selected from SCR 1, 2, 3 and 4 of long homologous repeat A (LHR-A) as the only structurally and functionally intact SCR domains of CR1 and including at least SCR3.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: November 10, 1998
    Assignee: Adprotech PLC
    Inventors: Danuta Ewa Irena Mossakowska, Ian Dodd, Anne Mary Freeman, Richard Anthony Godwin Smith