Abstract: The present invention relates to improved diagnostic methods for early detection of a risk for developing an arthritic disorder in humans, and screening assays for therapeutic agents useful in the treatment of arthritic disorders, by comparing the levels of one or more indicators of altered mitochondrial function. Indicators of altered mitochondrial function include enzymes such as mitochondrial enzymes and ATP biosynthesis factors. Other indicators of altered mitochondrial function include mitochondrial mass, mitochondrial number and mitochondrial DNA content, cellular responses to elevated intracellular calcium and to apoptogens, and free radical production. Methods of treating, and of stratifying, human patients as such methods relate to disclosed indicators of altered mitchondrial function are also provided.

Abstract: Compositions, articles and methods are provided for supplying fabric care benefits to clothing or fabrics in an automated washing machine and by manual washing. The fabric care compositions preferably have less than about 5% detergent surfactants, more preferably less than 3%, even more preferably less than 1% and are most preferably free of detergent surfactants. Similarly, the fabric care compositions preferably have less than about 5% fabric softener actives, more preferably less than 3%, even more preferably less than 1% and are most preferably free of detergent surfactants. The laundry articles can take a variety of forms in a variety of physical states all of which will rapidly dispense a unitized amount of one or more selected fabric care agents to a wash and/or rinse bath solution during the laundering process under a variety of conditions. The invention also pertains to laundry kits that contain a variety of such articles and instructions concerning their use.

Abstract: An article comprising a polyvinyl alcohol film encapsulating a fabric care composition is useful for conditioning laundry.

Abstract: An article comprising a polyvinyl alcohol film encapsulating a fabric care composition is useful for conditioning laundry.

Abstract: Compositions, articles and methods are provided for supplying fabric care benefits to clothing or fabrics in an automated washing machine and by manual washing. The fabric care compositions preferably have less than about 5% detergent surfactants, more preferably less than 3%, even more preferably less than 1% and are most preferably free of detergent surfactants. Similarly, the fabric care compositions preferably have less than about 5% fabric softener actives, more preferably less than 3%, even more preferably less than 1% and are most preferably free of detergent surfactants. The laundry articles can take a variety of forms in a variety of physical states all of which will rapidly dispense a unitized amount of one or more selected fabric care agents to a wash and/or rinse bath solution during the laundering process under a variety of conditions. The invention also pertains to laundry kits that contain a variety of such articles and instructions concerning their use.

Abstract: Compositions, articles and methods are provided for supplying fabric care benefits to clothing or fabrics in an automated washing machine and by manual washing. The fabric care compositions preferably have less than about 5% detergent surfactants, more preferably less than 3%, even more preferably less than 1% and are most preferably free of detergent surfactants. Similarly, the fabric care compositions preferably have less than about 5% fabric softener actives, more preferably less than 3%, even more preferably less than 1% and are most preferably free of detergent surfactants. The laundry articles can take a variety of forms in a variety of physical states all of which will rapidly dispense a unitized amount of one or more selected fabric care agents to a wash and/or rinse bath solution during the laundering process under a variety of conditions. The invention also pertains to laundry kits that contain a variety of such articles and instructions concerning their use.

Abstract: A method for identifying a gene having a role in the presentation of diabetic nephropathy comprises culturing mesangial cells in the presence of a concentration of glucose sufficient to induce differential expression, especially up-regulation, of a gene susceptible to such differential expression and identifying the gene so induced. The cells are also optionally subjected to mechanical strain and/or TGF-?1 can be added to the culture medium. The differentially expressed genes can be identified by suppression subtractive hybridisation. The method has resulted in the Identification of novel genes which play a role in the presentation of diabetic nephropathy. The genes can be used as diagnostic markers for diabetic nephropathy and as the basis of drug development programmes.

Abstract: Clear, or translucent fabric softener compositions comprise fabric softener compound, principal solvent system, and high electrolyte levels. The high electrolyte level allows for a broader range of principal solvents to be used and/or reduces the incidence of increased viscosity when low levels of principal solvent are used. Phase stabilizers which are primarily ethoxylated hydrophobic materials can be used to reduce the amount of principal solvent that is needed and/or to stabilize the compositions in the presence of the highest levels of electrolyte. Specific phase stabilizers provide additional benefits including improved softening. Specific electrolytes provide improved results. Addition of primary solvents and/or phase stabilizers to the softener compounds can improve the viscosity/handling of the compounds and the ability to create the finished compositions.

Abstract: Clear/translucent formulations comprise polyquaternary ammonium actives with lower, or no, solvent levels except the solvent which is normally present in the polyquaternary raw material stocks by choosing highly efficient principal solvents within a specific Clog P range, employing higher levels of polyquaternary ammonium actives, and/or augmenting the bilayer with surfactants and/or polar oils. Compositions with lowered solvent levels have at or below about 5% by volume of secondary dispersed phases, preferably below about 3% by volume of secondary dispersed phases, and more preferably below about 1% by volume of secondary dispersed phases. The most preferred compositions are essentially free of secondary dispersed phases. High-speed centrifugation easily and quickly reveals the % volume of secondary phase(s).

Abstract: Clear, or translucent fabric softener compositions comprise fabric softener compound, principal solvent system, and high electrolyte levels. The high electrolyte level allows for a broader range of principal solvents to be used and/or reduces the incidence of increased viscosity when low levels of principal solvent are used. Phase stabilizers which are primarily ethoxylated hydrophobic materials can be used to reduce the amount of principal solvent that is needed and/or to stabilize the compositions in the presence of the highest levels of electrolyte. Specific phase stabilizers provide additional benefits including improved softening. Specific electrolytes provide improved results. Addition of primary solvents and/or phase stabilizers to the softener compounds can improve the viscosity/handling of the compounds and the ability to create the finished compositions.

Abstract: An article comprising a polyvinyl alcohol film encapsulating a fabric care composition is useful for conditioning laundry.

Abstract: The invention provides methods for screening for agents that modulate mitochondrial function and in particular mitochondrial regulation of intracellular calcium. The methods may be used to detect agents that bind to a mitochondrial calcium uniporter and may also detect inhibitors or uncouplers of mitochondrial respiration. Agents identified using the screens provided herein have application in the prevention and treatment of a variety of diseases associated with abnormal mitochondrial function.

Abstract: Clear/translucent formulations comprise polyquaternary ammonium actives with lower, or no, solvent levels except the solvent which is normally present in the polyquaternary raw material stocks by choosing highly efficient solvents within a specific Clog P range, employing higher levels of polyquaternary ammonium, actives, and/or augmenting the bilayer with surfactants and/or polar oils. Compositions with lowered solvent levels have at or below about 5% by volume of secondary dispersed phases preferably below about 3% by volume of secondary dispersed phase, and more preferably 1% by volume of secondary dispersed phases. The most preferred compositions are essentially free of secondary dispersed phases. High-speed centrifugation easily and quickly reveals the % volume of secondary phase(s).

Abstract: Clear, or translucent fabric softener compositions comprise fabric softener compound, principal solvent system, and high electrolyte levels. The high electrolyte level allows for a broader range of principal solvents to be used and/or reduces the incidence of increased viscosity when low levels of principal solvent are used. Phase stabilizers which are primarily ethoxylated hydrophobic materials can be used to reduce the amount of principal solvent that is needed and/or to stabilize the compositions in the presence of the highest levels of electrolyte. Specific phase stabilizers provide additional benefits including improved softening. Specific electrolytes provide improved results. Addition of primary solvents and/or phase stabilizers to the softener compounds can improve the viscosity/handling of the compounds and the ability to create the finished compositions.

Abstract: Compositions, articles and methods are provided for supplying fabric care benefits to clothing or fabrics in an automated washing machine and by manual washing. The fabric care compositions preferably have less than about 5% detergent surfactants, more preferably less than 3%, even more preferably less than 1% and are most preferably free of detergent surfactants. Similarly, the fabric care compositions preferably have less than about 5% fabric softener actives, more preferably less than 3%, even more preferably less than 1% and are most preferably free of detergent surfactants. The laundry articles can take a variety of forms in a variety of physical states all of which will rapidly dispense a unitized amount of one or more selected fabric care agents to a wash and/or rinse bath solution during the laundering process under a variety of conditions. The invention also pertains to laundry kits that contain a variety of such articles and instructions concerning their use.

Abstract: Method and apparatus for updating a subscriber unit with an announcement group identification. A subscriber unit (210) requests affiliation (301) with a talk group (202) and an unknown announcement group identification is issued (315) in response to the request for affiliation. The present invention includes an embodiment where information that identifies which subscriber unit (210) received the unknown announcement group signal is stored (309). An updated announcement signal is subsequently sent to the subscriber unit (210) when a zone controller (114) receives an updated announcement group identification.

Abstract: Highly concentrated, preferably clear or translucent, fabric softener compositions comprising at least 40% softener active and less than about 20% water by weight of the composition for dispensing during the rinse cycle of a washing machine or for handwashing. The composition may be a liquid, granule or other standard form that is placed directly in the rinse bath or placed in a dispensing device for delayed dispensing into the rinse bath. Alternatively and preferably, the concentrated composition is incorporated or encapsulated in a unitized article for dispensing in the rinse bath or placement in a dispensing device for subsequent dispensing. The use of these compositions and articles provide added convenience and excellent fabric softening without staining or leaving residue on the fabrics.

Abstract: Compositions, articles and methods are provided for supplying fabric care benefits to clothing or fabrics in an automated washing machine and by manual washing. The fabric care compositions preferably have less than about 5% detergent surfactants, more preferably less than 3%, even more preferably less than 1% and are most preferably free of detergent surfactants. Similarly, the fabric care compositions preferably have less than about 5% fabric softener actives, more preferably less than 3%, even more preferably less than 1% and are most preferably free of detergent surfactants. The laundry articles can take a variety of forms in a variety of physical states all of which will rapidly dispense a unitized amount of one or more selected fabric care agents to a wash and/or rinse bath solution during the laundering process under a variety of conditions. The invention also pertains to laundry kits that contain a variety of such articles and instructions concerning their use.