Abstract: A dry powder inhaler, including a powder dispersion engine with one or more beads in a dispersion chamber, an airflow path leading into the dispersion chamber, an elongated tape with spaced apart blisters, each blister holding a dose of a dry powder, and blister opening mechanism that sequentially opens the blisters on the elongated tape and releases the dose of each blister into the airflow path.

Abstract: A dry powder inhaler, including a housing having an airflow path leading from an inlet, past a powder release location, to a mouthpiece; a drive spool engaged with a capstan adjacent to the powder release location; a spring biasing a ratchet into engagement with the drive spool; and a breath trigger in the airflow path. The breath trigger is moveable from a first position, wherein the breath trigger holds the ratchet, to a second position, wherein the breath trigger releases the ratchet to allow the ratchet to turn the drive spool.

Abstract: A method for operating a dry powder inhaler, the dry powder inhaler having a dose tape having spaced apart doses of a powder pharmaceutical, each dose being in a respective sealed blister. The inhaler includes a breath actuated blister opening system that sequentially opens a blister on the tape. The method involves routing the dose tape between first and second rotating elements; spring biasing the first rotating element to turn in a first direction; holding the first rotating element from rotating against the spring biasing; and releasing the first rotating element, and allowing it to rotate a fraction of one rotation, when air flows adjacent to the first rotating element.

Abstract: A dose tape for use in a dry powder inhaler has blisters formed in a formpack layer. A lidstock layer is attached over the formpack layer, to seal a dose of dry powder within each of the blisters. A tear strip is attached to the lidstock layer over each of the blisters. Pulling on the tear strip shears out an area of the lidstock over the blister, unsealing the powder contents.

Abstract: A dose tape for use in a dry powder inhaler has blisters formed in a formpack layer. A lidstock layer is permanently attached over the formpack layer, to seal a dose of dry powder within each of the blisters. A tear strip is attached to the lidstock layer over each of the blisters. The dose tape is provided in a coil within an inhaler having a breath actuated tape advance blister opening system. Moving a dustcap off of a mouthpiece into an open position places the tape advance/blister opening system into a ready condition. When the patient inhales on the mouthpiece, the tape advance/blister opening system is triggered. The blister or dose tape is advanced by one increment, and a blister is automatically opened. Pulling on the tear strip shears out an area of the lidstock over the blister, unsealing the powder contents. Airflow through an air path in the inhaler, generated by inhalation, carries the powder to a disbursion chamber, or directly to the mouthpiece, for inhalation by the patient.

Abstract: A dose tape for use in a dry powder inhaler has blisters formed in a formpack layer. A lidstock layer is permanently attached over the formpack layer, to seal a dose of dry powder within each of the blisters. A tear strip is attached to the lidstock layer over each of the blisters. The dose tape is provided in a coil within an inhaler having a breath actuated tape advance blister opening system. Moving a dustcap off of a mouthpiece into an open position places the tape advance/blister opening system into a ready condition. When the patient inhales on the mouthpiece, the tape advance/blister opening system is triggered. The blister or dose tape is advanced by one increment, and a blister is automatically opened. Pulling on the tear strip shears out an area of the lidstock over the blister, unsealing the powder contents. Airflow through an air path in the inhaler, generated by inhalation, carries the powder to a disbursion chamber, or directly to the mouthpiece, for inhalation by the patient.

Abstract: A dose tape for use in a dry powder inhaler has blisters formed in a formpack layer. A lidstock layer is permanently attached over the formpack layer, to seal a dose of dry powder within each of the blisters. A tear strip is attached to the lidstock layer over each of the blisters. The dose tape is provided in a coil within an inhaler having a breath actuated tape advance blister opening system. Moving a dustcap off of a mouthpiece into an open position places the tape advance/blister opening system into a ready condition. When the patient inhales on the mouthpiece, the tape advance/blister opening system is triggered. The blister or dose tape is advanced by one increment, and a blister is automatically opened. Pulling on the tear strip shears out an area of the lidstock over the blister, unsealing the powder contents. Airflow through an air path in the inhaler, generated by inhalation, carries the powder to a disbursion chamber, or directly to the mouthpiece, for inhalation by the patient.

Abstract: A dose tape for use in a dry powder inhaler has blisters formed in a formpack layer. A lidstock layer is permanently attached over the formpack layer, to seal a dose of dry powder within each of the blisters. A tear strip is attached to the lidstock layer over each of the blisters. The dose tape is provided in a coil within an inhaler having a breath actuated tape advance blister opening system. Moving a dustcap off of a mouthpiece into an open position places the tape advance/blister opening system into a ready condition. When the patient inhales on the mouthpiece, the tape advance/blister opening system is triggered. The blister or dose tape is advanced by one increment, and a blister is automatically opened. Pulling on the tear strip shears out an area of the lidstock over the blister, unsealing the powder contents. Airflow through an air path in the inhaler, generated by inhalation, carries the powder to a disbursion chamber, or directly to the mouthpiece, for inhalation by the patient.

Abstract: The present invention provides compounds of formula (I): 1