Abstract: Systems and methods are provided for monitoring and logging all activity occurring in a system. The logged activity may include keystroke entries input into the system, user and/or application interactions with the system, access restriction conflicts, and the like. The logged activity may be stored in at least two datastores, at least one of which is an immutable, append-only datastore. Storage of the logged activity in the immutable, append-only datastore is performed using hash algorithms. Attempts at manipulating or at hiding malicious or unauthorized activity can be recognized due to all activity being captured in the immutable, append-only datastore.

Abstract: Systems and methods are provided for monitoring and logging all activity occurring in a system. The logged activity may include keystroke entries input into the system, user and/or application interactions with the system, access restriction conflicts, and the like. The logged activity may be stored in at least two datastores, at least one of which is an immutable, append-only datastore. Storage of the logged activity in the immutable, append-only datastore is performed using hash algorithms. Attempts at manipulating or at hiding malicious or unauthorized activity can be recognized due to all activity being captured in the immutable, append-only datastore.

Abstract: Systems and methods are provided for monitoring and logging all activity occurring in a system. The logged activity may include keystroke entries input into the system, user and/or application interactions with the system, access restriction conflicts, and the like. The logged activity may be stored in at least two datastores, at least one of which is an immutable, append-only datastore. Storage of the logged activity in the immutable, append-only datastore is performed using hash algorithms. Attempts at manipulating or at hiding malicious or unauthorized activity can be recognized due to all activity being captured in the immutable, append-only datastore.

Abstract: Systems and methods are provided for monitoring and logging all activity occurring in a system. The logged activity may include keystroke entries input into the system, user and/or application interactions with the system, access restriction conflicts, and the like. The logged activity may be stored in at least two datastores, at least one of which is an immutable, append-only datastore. Storage of the logged activity in the immutable, append-only datastore is performed using hash algorithms. Attempts at manipulating or at hiding malicious or unauthorized activity can be recognized due to all activity being captured in the immutable, append-only datastore.

Abstract: A computer-implemented method for tracking computer system events and user actions is provided. The method includes detecting one or more system events of a computing system and one or more user actions performed on the computing system. The method also includes recording at least one system event and at least one user action. Additionally, the method includes synchronizing the recordation of the at least one system event and the recordation of the at least one user action. The method further includes presenting to a user the recordation of at least one system event and the recordation of at least one user action.

Abstract: A computer-implemented method for tracking computer system events and user actions is provided. The method includes detecting one or more system events of a computing system and one or more user actions performed on the computing system. The method also includes recording at least one system event and at least one user action. Additionally, the method includes synchronizing the recordation of the at least one system event and the recordation of the at least one user action. The method further includes presenting to a user the recordation of at least one system event and the recordation of at least one user action.

Abstract: GDNFR?, GDNFR? extracellular domain (ECD), GDNFR? variants, chimeric GDNFR? (e.g., GDNFR? immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to GDNFR?-ligands, for example GDNF, by providing GDNFR? to the cell. Also provided are methods for using GDNFR?, GDNF, or agonists thereof, separately or in complex, to treat kidney diseases.