Abstract: A calibration device for instrumentation for medical imaging, also called a “phantom,” including a matrix. The calibration device includes at least one additive for simulating the autofluorescence properties of an organ or of a living tissue in the spectral band covering the red and near infrared, said additive belonging to the porphyrin class, such as protoporphyrin IX.

Abstract: A method for locating at least one optical marker in a diffusing medium, the marker having at least one optical property different from the diffusing medium, wherein: a) a pulsed radiation interacts with the medium and the at least one optical marker, producing an optical signal, and at least one acquisition of data of the optical signal is performed, each acquisition including one or more time components of interest, due to the at least one marker, and a spurious component, due to the medium other than the at least one marker, b) a multidimensional array X is formed from the optical signal data of the at least one of the acquisitions, c) the array X is processed by factorization into a product of only two non-negative multidimensional arrays A and S, and d) at least one of the time components is extracted from the arrays A and S.

Abstract: A calibration device for instrumentation for medical imaging, also called a “phantom,” including a matrix. The calibration device includes at least one additive for simulating the autofluorescence properties of an organ or of a living tissue in the spectral band covering the red and near infrared, said additive belonging to the porphyrin class, such as protoporphyrin IX.

Abstract: A method is disclosed for locating at least one optical marker in a diffusing medium, said marker having at least one optical property different from the diffusing medium, method wherein: a) a pulsed radiation interacts with said medium and said at least one optical marker, producing an optical signal, and at least one acquisition of data of said optical signal is performed, each acquisition including one or more time components of interest, due to said at least one marker, and a spurious component, due to said medium other than said at least one marker, b) a multidimensional array X is formed from said optical signal data of said at least one of said acquisitions, c) said array X is processed by factorization into a product of only two non-negative multidimensional arrays A and S, d) at least one of said time components is extracted from said arrays A and S.

Abstract: A method for locating at least one fluorescent tag in a scattering medium, wherein: a) at least one tag is introduced into the medium, b) a fluorescence image is performed by an infrared excitation of the medium along a first axis, the image including a fluorescence component due to the tag, and an auto-fluorescence component due to a medium part other than the tags, c) the image is processed by factorizing into two non-negative matrices, and d) an image of the distribution of the tag(s) is determined, without the auto-fluorescence component.