Patents by Inventor Anne-Sophie Voisin-Chiret

Anne-Sophie Voisin-Chiret has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS TARGETING HSP110 PROTEIN FOR CANCER TREATMENT
    Publication number: 20210186941
    Abstract: HSP110 is involved in multiple tumorigenic processes but no inhibitor was known to date. The inventors have identified for the first time HSP110 inhibitors. These inhibitors bind directly to the nucleotide binding domain of HSP110 and then blocks the phosphorylation of STAT3, cancer cell growth or MyD88 stability. The present invention relates to a compound of general formula (I) for use in the treatment of a HSP 110-associated cancer, for example colorectal cancer and lymphoma. Especially the inventors tested the compound on two different colorectal mice models, a syngeneic model for which mouse colon cancer CT-26 cells were injected into Balb/c mice and a NOD/SCID model in which mice were implanted with human colorectal cancer HCT116 cells. In those animals bearing a tumor, the compound induced tumor regression that was associated with the inhibition of other HSP110 reported tumorigenic functions (resistance to apoptosis, induction of pro-tumor macrophages).
    Type: Application
    Filed: August 5, 2019
    Publication date: June 24, 2021
    Inventors: Carmen GARRIDO FLEURY, Gaetam JEGO, Daniel GONZALEZ, Anne-Sophie VOISIN-CHIRET
  • Mcl-1 modulating compounds for cancer treatment
    Patent number: 10307410
    Abstract: The invention relates to compounds of formula (I), and to their therapeutic use in the treatment of cancer: Wherein Y1, Y2, Ar1, Ar2, R1, R2, i, j, k, l are as defined in claim 1.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: June 4, 2019
    Assignees: CENTRE REGIONAL DE LUTTE CONTRE LE CANCER FRANCOIS BACLESSE, UNIVERSITE DE CAEN BASSE-NORMANDIE, INSTITUT DE CANCEROLOGIE DE L'OUEST RENE GAUDUCHEAU
    Inventors: Laurent Poulain, Anne-Sophie Voisin-Chiret, Jana Sopkova-de Oliveira Santos, Ronan Bureau, Grégory Burzicki, Marcella De Giorgi, Serge Perato, Jade Fogha, Sylvain Rault, Philippe Juin, Fabien Gautier
  • MCL-1 MODULATING COMPOUNDS FOR CANCER TREATMENT
    Publication number: 20170071921
    Abstract: The invention relates to compounds of formula (I), and to their therapeutic use in the treatment of cancer: Wherein Y1, Y2, Ar1, Ar2, R1, R2, i, j, k, l are as defined in claim 1.
    Type: Application
    Filed: March 3, 2015
    Publication date: March 16, 2017
    Applicants: CENTRE REGIONAL DE LUTTE CONTRE LE CANCER FRANCOIS BACLESSE, UNIVERSITE DE CAEN BASSE-NORMANDIE, INSTITUT DE CANCEROLOGIE DE L'OUEST RENE GAUDUCHEAU
    Inventors: Laurent POULAIN, Anne-Sophie VOISIN-CHIRET, Jana SOPKOVA-DE OLIVEIRA SANTOS, Ronan BUREAU, Grégory BURZICKI, Marcella DE GIORGI, Serge PERATO, Jade FOGHA, Sylvain RAULT, Philippe JUIN, Fabien GAUTIER
  • Guanidine derivatives in cinnamic series
    Patent number: 8853276
    Abstract: The invention relates to novel guanidine derivatives in the cinnamic series of general formula (I): The invention also relates to the process for preparing said guanidine derivatives and also to synthetic intermediates. Finally, the invention relates to the use of the guanidine derivatives for the preparation of compositions with anti-glycation properties, especially in cosmetology.
    Type: Grant
    Filed: September 6, 2011
    Date of Patent: October 7, 2014
    Assignee: Produits Chimiques Auxiliaires et de Synthese
    Inventors: Sylvain Rault, Jean Charles Lancelot, Peggy Suzanne, Anne-Sophie Voisin-Chiret, Regis Pecquet, Jean-Christophe Joseph
  • NEW GUANIDINE DERIVATIVES IN CINNAMIC SERIES
    Publication number: 20130165507
    Abstract: The invention relates to novel guanidine derivatives in the cinnamic series of general formula (I): The invention also relates to the process for preparing said guanidine derivatives and also to synthetic intermediates. Finally, the invention relates to the use of the guanidine derivatives for the preparation of compositions with anti-glycation properties, especially in cosmetology.
    Type: Application
    Filed: September 6, 2011
    Publication date: June 27, 2013
    Applicant: PRODUITS CHIMIQUES AUXILIAIRES ET DE SYNTHESE
    Inventors: Sylvain Rault, Jean Charles Lancelot, Peggy Suzanne, Anne-Sophie Voisin-Chiret, Regis Pecquet, Jean-Christophe Joseph