Patents by Inventor Anne T. Perrotta

Anne T. Perrotta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzymatic RNA molecules
    Patent number: 5712128
    Abstract: Nucleic acid molecule having an RNA substrate cleaving enzymatic activity which cleaves a separate RNA substrate at a cleavage site. The nucleic acid molecule includes an RNA substrate binding portion which base pairs with the RNA substrate only 3' of the cleavage site, and an enzymatic portion (which may include a part or all of the RNA substrate binding portion) having the enzymatic activity. The nucleic acid molecule is able to base pair with the RNA substrate only 3' of the cleavage site, and cause cleavage of the RNA substrate at that cleavage site. The nucleic acid molecule can be either linear or circular. A general method for forming circular RNA in vivo and in vitro is provided.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: January 27, 1998
    Assignee: Duke University
    Inventors: Michael D. Been, Sarah P. Rosenstein, Anne T. Perrotta
  • Enzymatic RNA molecules
    Patent number: 5625047
    Abstract: Nucleic acid molecule having an RNA substrate cleaving enzymatic activity which cleaves a separate RNA substrate at a cleavage site. The nucleic acid molecule includes an RNA substrate binding portion which base pairs with the RNA substrate only 3' of the cleavage site, and an enzymatic portion (which may include a part or all of the RNA substrate binding portion) having the enzymatic activity. The nucleic acid molecule is able to base pair with the RNA substrate only 3' of the cleavage site, and cause cleavage of the RNA substrate at that cleavage site. The nucleic acid molecule can be either linear or circular. A general method for forming circular RNA in vivo and in vitro is provided.
    Type: Grant
    Filed: May 5, 1994
    Date of Patent: April 29, 1997
    Assignee: Duke University
    Inventors: Michael D. Been, Sarah P. Rosenstein, Anne T. Perrotta