Patents by Inventor Anne V. Edwards

Anne V. Edwards has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic heteroaryl compounds and uses thereof
    Patent number: 12258366
    Abstract: The present disclosure is directed to modulators of SOS1 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: October 11, 2022
    Date of Patent: March 25, 2025
    Assignee: Revolution Medicines, Inc.
    Inventors: Adrian L. Gill, Andreas Buckl, Elena S. Koltun, Naing Aay, Arlyn A. Tambo-ong, Severin Thompson, Micah James Gliedt, John E. Knox, James Cregg, Anne V. Edwards, Yang Liu, G. Leslie Burnett
  • METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR
    Publication number: 20250090526
    Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: April 22, 2024
    Publication date: March 20, 2025
    Inventors: Suzanne JACKOWSKI, Charles O. ROCK, Richard E. LEE, Lalit Kumar SHARMA, Mi Kyung YUN, Chitra SUBRAMANIAN, Rajendra P. TANGALLAPALLY, Anne V. EDWARDS, Robert ZAMBONI, T. Jagadeeswar REDDY, Jiuyu LIU
  • Ras inhibitors
    Patent number: 12252497
    Abstract: The invention features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
    Type: Grant
    Filed: May 5, 2022
    Date of Patent: March 18, 2025
    Assignee: Revolution Medicines, Inc.
    Inventors: G. Leslie Burnett, James Cregg, Anne V. Edwards, Adrian L. Gill, John E. Knox, Elena S. Koltun, Jennifer Pitzen, Christopher Semko
  • RAS INHIBITORS
    Publication number: 20250074923
    Abstract: The invention features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
    Type: Application
    Filed: November 14, 2024
    Publication date: March 6, 2025
    Inventors: John E. KNOX, Elena S. KOLTUN, Yang LIU, G. Leslie BURNETT, James CREGG, Anne V. EDWARDS, Adrian L. GILL, Andreas BUCKL, Christopher SEMKO
  • RAS INHIBITORS
    Publication number: 20250051306
    Abstract: The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
    Type: Application
    Filed: February 29, 2024
    Publication date: February 13, 2025
    Inventors: James Aggen, G. Leslie Burnett, Jennifer Pitzen, Adrian L. Gill, Elena S. Koltun, James Cregg, Andreas Buckl, Anne V. Edwards, Christopher Semko, Micah James Gliedt, John E. Knox, William D. Thomas
  • Ras inhibitors
    Patent number: 12202845
    Abstract: The invention features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
    Type: Grant
    Filed: October 7, 2022
    Date of Patent: January 21, 2025
    Assignee: Revolution Medicines, Inc.
    Inventors: John E. Knox, Elena S. Koltun, Yang Liu, G. Leslie Burnett, James Cregg, Anne V. Edwards, Adrian L. Gill, Andreas Buckl, Christopher Semko
  • SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES
    Publication number: 20240287039
    Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: December 20, 2023
    Publication date: August 29, 2024
    Inventors: Richard E. LEE, Rajendra P. TANGALLAPALLY, Charles O. ROCK, Suzanne JACKOWSKI, Anne V. EDWARDS, Mi Kyung YUN, Chitra SUBRAMANIAN, Robert ZAMBONI, T. Jagadeeswar REDDY
  • COVALENT RAS INHIBITORS AND USES THEREOF
    Publication number: 20240262847
    Abstract: The disclosure features compounds, or pharmaceutically acceptable salts thereof, alone and in combination with other therapeutic agents, pharmaceutical compositions, and protein conjugates thereof, capable of modulating biological processes including Ras, and their uses in the treatment of cancers.
    Type: Application
    Filed: November 3, 2023
    Publication date: August 8, 2024
    Inventors: G. Leslie BURNETT, Anne V. EDWARDS, Adrian L. GILL, John E. KNOX, Elena S. KOLTUN, Jennifer PITZEN
  • Small molecule modulators of pantothenate kinases
    Patent number: 11891378
    Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: February 6, 2024
    Assignees: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC., COA THERAPEUTICS, INC.
    Inventors: Richard E. Lee, Rajendra P. Tangallapally, Charles O. Rock, Suzanne Jackowski, Anne V. Edwards, Mi Kyung Yun, Chitra Subramanian, Robert Zamboni, T. Jagadeeswar Reddy
  • BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF
    Publication number: 20230365605
    Abstract: The present disclosure is directed to modulators of SOS1 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
    Type: Application
    Filed: October 11, 2022
    Publication date: November 16, 2023
    Inventors: Adrian L. Gill, Andreas Buckl, Elena S. Koltun, Naing Aay, Arlyn A. Tambo-ong, Severin Thompson, Micah James Gliedt, John E. Knox, James Cregg, Anne V. Edwards, Yang Liu, G. Leslie Burnett
  • METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR
    Publication number: 20230321092
    Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: December 6, 2022
    Publication date: October 12, 2023
    Inventors: Suzanne JACKOWSKI, Charles O. ROCK, Richard E. LEE, Lalit Kumar SHARMA, Mi Kyung YUN, Chitra SUBRAMANIAN, Rajendra P. TANGALLAPALLY, Anne V. EDWARDS, Robert ZAMBONI, T. Jagadeeswar REDDY, Jiuyu LIU
  • RAS INHIBITORS
    Publication number: 20230303591
    Abstract: The invention features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
    Type: Application
    Filed: October 7, 2022
    Publication date: September 28, 2023
    Inventors: Andreas Buckl, G. Leslie Burnett, James Cregg, Anne V. Edwards, Adrian L. Gill, John E. Knox, Elena S. Koltun, Yang Liu, Christopher Semko
  • Ras inhibitors
    Patent number: 11739074
    Abstract: The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: August 29, 2023
    Assignee: Revolution Medicines, Inc.
    Inventors: James Aggen, G. Leslie Burnett, Jennifer Pitzen, Adrian L. Gill, Elena S. Koltun, James Cregg, Andreas Buckl, Anne V. Edwards, John E. Knox
  • COVALENT RAS INHIBITORS AND USES THEREOF
    Publication number: 20230100838
    Abstract: The disclosure features compounds, or pharmaceutically acceptable salts thereof, alone and in combination with other therapeutic agents, pharmaceutical compositions, and protein conjugates thereof, capable of modulating biological processes including Ras, and their uses in the treatment of cancers.
    Type: Application
    Filed: May 26, 2022
    Publication date: March 30, 2023
    Inventors: Jennifer PITZEN, James AGGEN, G. Leslie BURNETT, Adrian L. GILL, Christopher SEMKO, Anne V. EDWARDS, Micah James GLIEDT, Gert KISS, Ashutosh JOGALEKAR, John E. KNOX, Andreas BUCKL, Elena S. KOLTUN
  • Methods of treating disorders associated with castor
    Patent number: 11547709
    Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: January 10, 2023
    Assignees: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC., COA THERAPEUTICS, INC.
    Inventors: Suzanne Jackowski, Charles O. Rock, Richard E. Lee, Lalit Kumar Sharma, Mi Kyung Yun, Chitra Subramanian, Rajendra P. Tangallapally, Anne V. Edwards, Robert Zamboni, T. Jagadeeswar Reddy, Jiuyu Liu
  • RAS INHIBITORS
    Publication number: 20220396589
    Abstract: The invention features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
    Type: Application
    Filed: May 5, 2022
    Publication date: December 15, 2022
    Inventors: Andreas BUCKL, G. Leslie BURNETT, James CREGG, Anne V. EDWARDS, Adrian L. GILL, John E. KNOX, Elena S. KOLTUN, Jennifer PITZEN, Christopher SEMKO
  • SMALL MOLECULE MODULATORS OF PANK
    Publication number: 20220185796
    Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: March 26, 2020
    Publication date: June 16, 2022
    Inventors: Ragendra P. Tangallapally, Richard E. Lee, Anne V. Edwards, Charles O. Rock, Suzanne Jackowski, Mi Kyung Yun, Chitra Subramanian
  • Bicyclic heteroaryl compounds and uses thereof
    Patent number: 11168102
    Abstract: The present disclosure is directed to modulators of SOS1 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same. Modulators of SOS1 have the following general structure of the Formula (II), or a pharmaceutically acceptable salt or a stereoisomer thereof, wherein the variables are as defined herein.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: November 9, 2021
    Assignee: Revolution Medicines, Inc.
    Inventors: Adrian L. Gill, Andreas Buckl, Elena S. Koltun, Naing Aay, Arlyn A. Tambo-ong, Severin Thompson, Micah James Gliedt, John E. Knox, James Cregg, Anne V. Edwards, Yang Liu, G. Leslie Burnett
  • BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF
    Publication number: 20210139517
    Abstract: The present disclosure is directed to modulators of SOS1 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
    Type: Application
    Filed: November 5, 2020
    Publication date: May 13, 2021
    Inventors: Adrian L. Gill, Andreas Buckl, Elena S. Koltun, Naing Aay, Arlyn A. Tambo-ong, Severin Thompson, Micah James Gliedt, John E. Knox, James Cregg, Anne V. Edwards, Yang Liu, G. Leslie Burnett
  • RAS INHIBITORS
    Publication number: 20210130326
    Abstract: The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
    Type: Application
    Filed: November 4, 2020
    Publication date: May 6, 2021
    Inventors: James AGGEN, G. Leslie BURNETT, Jennifer PITZEN, Adrian L. GILL, Elena S. KOLTUN, James CREGG, Andreas BUCKL, Anne V. EDWARDS, Christopher SEMKO, Micah James GLIEDT, John E. KNOX