Patents by Inventor Anne W. Dombrowski

Anne W. Dombrowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIV integrase inhibitors
    Patent number: 6541515
    Abstract: Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The culture Cytospora sp. MF 6608 (ATCC PTA-1691) is also disclosed, as well as processes for making a compound of the present invention employing the culture.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: April 1, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Sheo Bux Singh, Hiranthi Jayasuriya, Ziqiang Guan, Keith C. Silverman, Russell B. Lingham, Anne W. Dombrowski, Daria J. Hazuda, Jon D. Polishook
  • Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control
    Patent number: 6436395
    Abstract: Disclosed is a method for controlling phytopathogenic fungi using pure strains of Rosellinia subiculata ATCC 74386 and fungus ATCC 74387. Further, methods of producing a sordarin compound are disclosed. The method includes cultivating each strain separately in a nutrient medium containing assimilable sources of carbon and nitrogen and recovering the compound. A sordarin compound of formula I is also disclosed. Also an antifungal composition containing a sordarin compound is also disclosed.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: August 20, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Gerald F. Bills, Anne W. Dombrowski, Wendy S. Horn, Richard K. Jansson, Mark Rattray, Dennis Schmatz, Robert E. Schwartz
  • HIV integrase inhibitors
    Publication number: 20020045658
    Abstract: Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The culture Cytospora sp. MF 6608 (ATCC PTA-1691) is also disclosed, as well as processes for making a compound of the present invention employing the culture.
    Type: Application
    Filed: August 9, 2001
    Publication date: April 18, 2002
    Inventors: Sheo Bux Singh, Hiranthi Jayasuriya, Ziqiang Guan, Keith C. Silverman, Russell B. Lingham, Anne W. Dombrowski, Daria J. Hazuda, Jon D. Polishook
  • HIV INTEGRASE INHIBITORS
    Publication number: 20010014748
    Abstract: Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. Further, the culture Fusarium sp., MF6381 (ATCC 74469) is also disclosed, as well as processes for making compounds of structural formula I employing the culture Fusarium sp., MF6381 (ATCC 74469).
    Type: Application
    Filed: December 13, 1999
    Publication date: August 16, 2001
    Inventors: SHEO BUX SINGH, DEBORAH L. ZINK, DARIA JEAN HAZUDA, PETER J. FELOCK, JON DAVID POLISHOOK, ANNE W. DOMBROWSKI
  • HIV integrase inhibitors
    Patent number: 6271402
    Abstract: Compound of formula I: wherein the R groups are as defined by the specification. The compounds are useful in the inhibition of HIV integrase, the treatment of infection of HIV and treatment of AIDS.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: August 7, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Sheo Bux Singh, Deborah L. Zink, Daria Jean Hazuda, Peter J. Felock, Anne W. Dombrowski
  • Antiprotozoal cyclic tetrapeptides
    Patent number: 5861375
    Abstract: The present invention provides novel cyclic tetrapeptides useful in the treatment or prevention of protozoal diseases; in particular, the novel compounds are active against the causative pathogens in malaria, toxoplasmosis, and coccidiosis.
    Type: Grant
    Filed: January 28, 1997
    Date of Patent: January 19, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Christine Lange Cannova, Anne W. Dombrowski, Michael A. Goetz, Sandra J. Rattray, Sheo Bux Singh, Jon Polishook, Gerald F. Bills, Joyce A. Greene, Gary K. Darland
  • In vitro HIV integrase inhibitors
    Patent number: 5759842
    Abstract: Natural products such as equisetin and derivatives are described. These compounds are useful in the inhibition of HIV integrase.
    Type: Grant
    Filed: October 24, 1996
    Date of Patent: June 2, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Anne W. Dombrowski, Jeffrey C. Hastings, Daria Jean Hazuda, Jon David Polishook, Sheo Bux Singh
  • Antiprotozoal cyclic tetrapeptides
    Patent number: 5620953
    Abstract: The present invention provides novel cyclic tetrapeptides useful in the treatment or prevention of protozoal diseases; in particular, the novel compounds are active against the causative pathogens in malaria, toxoplasmosis, and coccidiosis.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: April 15, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Christine L. Cannova, Michael A. Goetz, Anne W. Dombrowski, Sandra J. Rattray, Sheo B. Singh, Gerald F. Bills, Jon Polishook, Joyce A. Greene, Gary K. Darland
  • Antiparasitic agents
    Patent number: 5614546
    Abstract: There are disclosed novel compounds which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal gents.
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: March 25, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Anne W. Dombrowski, Richard G. Endris, Gregory L. Helms, Otto D. Hensens, John G. Ondeyka, Dan A. Ostlind, Jon D. Polishook, Deborah L. Zink
  • Antifungal agents
    Patent number: 5597806
    Abstract: There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: January 28, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Wendy H. Clapp, Guy H. Harris, Gerald F. Bills, James E. Curotto, Anne W. Dombrowski, Sarah J. Driekorn, Myra B. Kurtz, Maria S. Meinz, Janet C. Onishi, Jon D. Polishook, Stanley L. Streicher, John R. Thompson, Marie Williams, Deborah L. Zink
  • Antiparasitic agents
    Patent number: 5399582
    Abstract: There are disclosed novel compounds which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal gents.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: March 21, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Anne W. Dombrowski, Richard G. Endris, Gregory L. Helms, Otto D. Hensens, John G. Ondeyka, Dan A. Ostlind, Jon D. Polishook, Deborah L. Zink
  • Processes for preparing cholesterol lowering compounds
    Patent number: 5244795
    Abstract: This invention relates to processes employing cultures which are useful for preparing compounds of structural formula (I).
    Type: Grant
    Filed: August 20, 1992
    Date of Patent: September 14, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Anne W. Dombrowski, Lawrence Koupal
  • Culture of Asperigillus versicolor and mutants thereof
    Patent number: 5151365
    Abstract: This invention relates to cultures and processes employing these cultures which are useful for preparing compounds of structural formula (I).
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: September 29, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Anne W. Dombrowski, Lawrence Koupal