Abstract: Fluid delivery devices for delivering therapeutic agents are described. More particularly, this disclosure relates to drug reconstitution devices having a plurality of components movable with respect to one another such that an active agent and a solvent can be reconstituted within the device prior to injection. The fluid delivery devices can include a housing, a cartridge holder, a cartridge disposed within the cartridge holder, a button rod, and a foot. The cartridge stores the active agent and the solvent, which are separated by one or more stoppers. The button rod and foot can provide an axial force upon the stopper(s) in the cartridge to inject the fluid once reconstituted. The foot and the button rod can be separate components, thereby enabling the foot to rotate independently with respect to the button rod as the cartridge holder is rotated to reconstitute the therapeutic and prime the device for injection.

Abstract: The present invention provides compositions comprising a recombinant AAV and one or more pharmaceutically acceptable excipients. The compositions have improved stability and shelf life as compared to other AAV compositions.

Abstract: The disclosure provides a method of using blood or fractions thereof, e.g., serum, obtained from a mammal subjected to liver surgery, for example, obtained following a partial hepatectomy, to increase the engraftment, proliferation and/or functionality of cells on a biocompatible scaffold.

Abstract: Disclosed herein are compositions and methods to decellularize an isolated organ or portion thereof. Also disclosed herein are compositions and methods for treatment of disease utilizing a decellularized or recellularized organ. Also disclosed herein are methods of improving decellularization and/or recellularization of an isolated organ or portion thereof.

Abstract: The disclosure provides a method of using blood or fractions thereof, e.g., serum, obtained from a mammal subjected to liver surgery, for example, obtained following a partial hepatectomy, to increase the engraftment, proliferation and/or functionality of cells on a biocompatible scaffold.

Abstract: A lubricant additive concentrate containing (i) dispersant that is the polybutenyl succinimide reaction product of a polyamine and polybutenyl succinic anhydride (PIBSA) derived from polybutene having a number average molecular weight (Mn) of from about 1300 to about 2500 daltons and a terminal vinylidene content of at least about 50% and maleic anhydride via an ene maleation process; (ii) overbased magnesium colloidal detergent having a total base number (TBN) of from about 300 to about 900 mg KOH/g; and (iii) organic friction modifier selected from hydroxyalkyl alkyl amines of C14 to C24 hydrocarbons, at least one hydroxyalkyl alkyl ether amines of C13 to C24 hydrocarbons, at least one alkyl ester amine derived from triethanol amine having a C13 to C24 hydrocarbyl substituent, at least one non-basic, fatty acid amide, or a mixture thereof; wherein the combined mass % of dispersant (i) and overbased magnesium colloidal detergent (ii) in said concentrate is from about 15 to about 50 mass %: the mass ratio of

Abstract: The disclosure provides a method of using blood or fractions thereof, e.g., serum, obtained from a mammal subjected to liver surgery, for example, obtained following a partial hepatectomy, to increase the engraftment, proliferation and/or functionality of cells on a biocompatible scaffold.

Abstract: A method for attenuating effects of free radicals on a keratinous material of a subject in need thereof, comprising applying a composition to the keratinous material is provided. The composition comprises a physiologically or pharmaceutically acceptable medium and a short chain polypeptide having four amino acid units of a specific formula. The composition may be a sunscreen, a skin cream, a shampoo or a hair conditioner.

Abstract: A lubricant additive concentrate containing (i) dispersant that is the polybutenyl succinimide reaction product of a polyamine and polybutenyl succinic anhydride (PIBSA) derived from polybutene having a number average molecular weight (Mn) of from about 1300 to about 2500 daltons and a terminal vinylidene content of at least about 50% and maleic anhydride via an ene maleation process; (ii) overbased magnesium colloidal detergent having a total base number (TBN) of from about 300 to about 900 mg KOH/g; and (iii) organic friction modifier selected from hydroxyalkyl alkyl amines of C14 to C24 hydrocarbons, at least one hydroxyalkyl alkyl ether amines of C13 to C24 hydrocarbons, at least one alkyl ester amine derived from triethanol amine having a C13 to C24 hydrocarbyl substituent, at least one non-basic, fatty acid amide, or a mixture thereof; wherein the combined mass % of dispersant (i) and overbased magnesium colloidal detergent (ii) in said concentrate is from about 15 to about 50 mass %: the mass ratio of

Abstract: A short chain polypeptide having antioxidant activity is provided. The short chain polypeptide has 2 to 4 amino acids bonded to form a polypeptide chain having an amine-terminal end and a carboxyl terminal end; wherein a net charge of the short chain polypeptide is positive, the amino terminal amino acid is an amino acid selected from the group consisting of arginine, lysine and histidine, the polypeptide chain following from the amino terminus comprises a hydrophobic or neutral amino acid, and the polypeptide chain is free of an amino acid having a negatively charged side-chain group. A method to prepare a composition having antioxidant activity and a composition having antioxidant activity are also provided.

Abstract: A method for attenuating effects of free radicals on a keratinous material of a subject in need thereof, comprising applying a composition to the keratinous material is provided. The composition comprises a physiologically or pharmaceutically acceptable medium and a short chain polypeptide having four amino acid units of a specific formula. The composition may be a sunscreen, a skin cream, a shampoo or a hair conditioner.

Abstract: A short chain polypeptide having antioxidant activity is provided. The short chain polypeptide has 2 to 4 amino acids bonded to form a polypeptide chain having an amine-terminal end and a carboxyl terminal end; wherein a net charge of the short chain polypeptide is positive, the amino terminal amino acid is an amino acid selected from the group consisting of arginine, lysine and histidine, the polypeptide chain following from the amino terminus comprises a hydrophobic or neutral amino acid, and the polypeptide chain is free of an amino acid having a negatively charged side-chain group. A method to prepare a composition having antioxidant activity and a composition having antioxidant activity are also provided.

Abstract: This invention relates to an oil absorbing comb and methods for its use. The novel comb of this invention is capable of absorbing significant amounts of oil from mammalian hair or other substrates and methods of using said comb.

Abstract: The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another.

Abstract: The invention provides novel compounds selected from the group consisting of: 1