Patents by Inventor Anneliese Crueger

Anneliese Crueger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for preparing acarviosyl transferase and for using it in the conversion of acarbose homologues into acarbose, for the preparation of acarbose homologues
    Patent number: 5989882
    Abstract: The invention relates to acarviosyl transferase from actinomycetes, mainly from Actinoplanes sp. SE 50/110 and its mutants, to a process for isolating, purifying and characterizing the enzyme, to the isolation and characterization of the acbD gene encoding the acarviosyl transferase, to the expression of the acarviosyl transferase in a heterologous host organism, to the use of the acarviosyl transferase for converting acarbose minor constituents into acarbose or for preparing acarbose homologues, to the use of the acarviosyl transferase in acarbose purification, and also to the preparation of production mutants in which formation of minor constituents is reduced by means of inactivation of the acarviosyl transferase gene.
    Type: Grant
    Filed: March 14, 1997
    Date of Patent: November 23, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Anneliese Crueger, Hans-Georg Dellweg, Jurgen Georg Lenz, Werner Schroder, Hermann Pape, Klaus Goeke, Beate Schaper, Michael Hemker, Wolfgang Piepersberg, Jurgen Distler, Ansgar Stratmann
  • Acarbose biosynthesis genes from actinoplanes sp., process for the isolation thereof and the use thereof
    Patent number: 5753501
    Abstract: The invention relates to acarbose biosynthesis genes from actinomycetes, predominantly from Actinoplanes sp. SE 50/110 and its mutants, to a process for the isolation of acarbose biosynthesis genes from actinomycetes using a gene probe which has been derived from highly conserved protein regions of known dTDP-glucose dehydratase enzymes for finding the genes acbA (coding for dTDP-glucose synthase), acbB (coding for dTDP-glucose dehydratase) and acbC (coding for a cyclase, in part identical to AroB, bacterial 3-dehydroquinate synthases) or one or more acarbose biosynthesis genes from Actinoplanes sp., and to the use of the acarbose biosynthesis genes.
    Type: Grant
    Filed: February 23, 1996
    Date of Patent: May 19, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Anneliese Crueger, Wolfgang Piepersberg, Jurgen Distler, Ansgar Stratmann