Abstract: A method is provided for treating a surface containing a plurality of functional groups. The method includes reacting the plurality of functional groups with a linking group, thereby creating a surface containing a plurality of linking groups; and binding a first peptoid to each of the plurality of linking groups, thereby obtaining a first treated surface.

Abstract: A method is provided for treating a subject suffering from a chronic infection that involves the brain. The chronic infection may range from those causing only mild cognitive impairment, to those present in individuals who have been diagnosed with Alzheimer's Disease. The method includes forming a composition containing (a) an anti-infective peptoid, and (b) a blood-brain barrier (BBB) manipulator that enhances the ability of the anti-infective peptoid to cross the BBB; and administering a therapeutic amount of the composition to a subject in need thereof.

Abstract: A method for treating a subject suffering from a disease is provided. The method includes diagnosing the subject as suffering from a disease; upregulating the cathelicidin gene CAMP in the subject; and administering to the subject at least one treatment for the disease.

Abstract: In one aspect, a method is provided for performing light therapy on a subject. The method comprises providing a device which emits electromagnetic radiation that oscillates between at least first and second distinct polarization states; and illuminating the subject with the emitted electromagnetic radiation. In another aspect, a fixture is provided which comprises a first source of electromagnetic radiation which emits electromagnetic radiation in a first polarization state; a second source of electromagnetic radiation which emits electromagnetic radiation in a second polarization state which is distinct from said first polarization state; and an oscillator which oscillates electromagnetic radiation output by the fixture between at least said first and second polarization states.

Abstract: Systems and methodologies are provided for performing brainwave entrainment on a subject. An exemplary embodiment of these methodologies includes providing a signal source selected from the group consisting of audio signal sources and video signal sources; and using the signal source to apply to the subject, or to induce the formation of in the subject, at least one nested waveform selected from the group consisting of audio waves and electromagnetic waves.

Abstract: A method is provided for treating a recipient with a biological product obtained from at least one donor that may be the same as, or different from, the recipient. The method includes identifying a targeted level of gene expression of a first gene in a biological product to be transferred from at least one donor to a recipient; treating the at least one donor to achieve the targeted level of gene expression of the first gene in the biological product; and transferring the biological product from the at least one donor to the recipient.

Abstract: A method is provided for treating a subject. The method comprises diagnosing the subject as suffering from a condition arising from the presence in the subject of a causative agent; and administering to the subject a pharmaceutically effective amount of a substance having (a) a hydrophobic, helical region, (b) an N-terminal region that includes at least one proline residue, (c) a first linking moiety that links the hydrophobic helical region to the N-terminal region, said linking moiety being equipped with at least one lysine-like side chain, (d) a binding moiety which binds to the causative agent, and (e) a second linking moiety that links the binding moiety to the N-terminal region.

Abstract: A method is provided for treating a recipient with a biological product obtained from at least one donor that may be the same as, or different from, the recipient. The method includes identifying a targeted level of gene expression of a first gene in a biological product to be transferred from at least one donor to a recipient; treating the at least one donor to achieve the targeted level of gene expression of the first gene in the biological product; and transferring the biological product from the at least one donor to the recipient.

Abstract: A contraceptive device is provided which includes a (preferably elastomeric) surface; and a lubricant applied to the surface. The lubricant includes (a) a lubricious medium, and (b) a pharmaceutically effective amount of a peptoid disposed in said lubricious medium. The antimicrobial peptoid may impart protection against some common sexually transmitted diseases, while also imparting spermicidal activity to the lubricious medium and contraceptive device.

Abstract: A method for treating a subject suffering from cancer is provided. The method includes diagnosing the subject as suffering from cancer; obtaining Natural Killer (NK) white blood cells; upregulating the cathelicidin gene CAMP in the subject; and infusing the NK cells into the body of the subject.

Abstract: A polytherapy of orally available compounds is disclosed that synergistically modulates and induces the expression of the cathelicidin gene (CAMP), which encodes the host defense peptide LL-37. By providing a number of different CAMP-inducing compounds together at the same time, stronger gene induction is achieved than with just one or two compounds, because the mechanism of induction broadens. Induction also may vary in different pas of the body depending on which compounds are used, and at what levels. We show for the first time that the polytherapy can induce cathelicidin expression in the brain, which may help to treat or prevent Alzheimer's Disease Systemic cathelicidin gene induction may help treat numerous other conditions including Type 2 Diabetes/Metabolic Syndrome, or chronic bacterial, viral, or fungal infections associated with increased cancer risk or neurodegeneration.

Abstract: A method is provided for performing electromagnetic radiation therapy on a subject. The method comprises providing a device which emits electromagnetic radiation, wherein the electromagnetic radiation includes a first portion that oscillates between at least first and second distinct states, and a second non-oscillatory portion; and illuminating the subject with the electromagnetic radiation.

Abstract: A method is provided for treating a subject for a viral infection. The method includes diagnosing the subject as having a viral infection, and administering a pharmaceutically effective amount of a pharmaceutical composition to the subject. The pharmaceutical composition includes a poly-N-substituted glycine compound of a formula AX-Y-Zn—B, wherein A is a terminal N-alkyl substituted glycine residue; n is an integer; B is selected from the group consisting of NH2, one and two N-substituted glycine residues, and wherein said one and two N-substituted glycine residues have N-substituents which are independently selected from natural ?-amino acid side chain moieties, isomers and carbon homologs thereof; X, Y and Z are independently selected from the group consisting of N-substituted glycine residues, wherein said N-substituents are independently selected from the group consisting of natural ?-amino acid side chain moieties, isomers and carbon homologs thereof, and proline residues.

Abstract: A method for treating a subject is provided. The method includes performing surgery on the subject such as, for example, a carotid endarterectomy. Light therapy is administered to the subject as an adjuvant to the surgery.

Abstract: A method is provided for treating a subject for clinical depression or major depression, traumatic brain injury, opioid addiction, or other such physiological of psychological condition. The method includes diagnosing the subject as suffering from the condition; providing a light therapy unit comprising (a) a chassis, (b) a plurality of LEDs disposed on said chassis, and (c) a controller which controls the operation of said LEDs; and operating the plurality of LEDs at a plurality of distinct wavelengths of light such that the light emitted by the LEDs impinges on the subject, and such that the intensity of at least one of the plurality of distinct wavelengths of light is modulated at a frequency within the range of about 20 Hz to about 60 Hz.

Abstract: A method is provided for treating a recipient with a biological product obtained from at least one donor that may be the same as, or different from, the recipient. The method includes identifying a targeted level of gene expression of a first gene in a biological product to be transferred from at least one donor to a recipient; treating the at least one donor to achieve the targeted level of gene expression of the first gene in the biological product; and transferring the biological product from the at least one donor to the recipient.

Abstract: Immobilizable antimicrobial compounds incorporating antimicrobial and/or antifouling components, as can be adhered to various device structures and components.

Abstract: A polytherapy of orally available compounds is disclosed that synergistically modulates and induces the expression of the cathelicidin gene (CAMP), which encodes the host defense peptide LL-37. By providing a number of different CAMP-inducing compounds together at the same time, stronger gene induction is achieved than with just one or two compounds, because the mechanism of induction broadens. Induction also may vary in different parts of the body depending on which compounds are used, and at what levels. We show for the first time that the polytherapy can induce cathelicidin expression in the brain, which may help to treat or prevent Alzheimer's Disease. Systemic cathelicidin gene induction may help treat numerous other conditions including Type 2 Diabetes/Metabolic Syndrome, or chronic bacterial, viral, or fungal infections associated with increased cancer risk or neurodegeneration.

Abstract: The present invention relates to systems, compositions, and methods for nucleic acid sequencing and analysis in free-solution using protein polymer drag-tags. As such, the present invention provides protein-based molecular compositions that find use as drag-tags for use in sequencing and nucleic acid analysis methods and provides systems and methods for automated sequencing and analysis of nucleic acids in free solution.

Abstract: The present disclosure provides substantially monodisperse random coil polypeptides, vectors encoding the polypeptides, conjugates containing the polypeptides, methods for their preparation, and their uses in nucleic acid separations, DNA sequencing, and other applications requiring high monodispersity.