Patents by Inventor Annemarie Honegger

Annemarie Honegger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies Against IL-1 Beta
    Publication number: 20230203151
    Abstract: The present invention relates to anti-IL-1 beta antibodies and in particular to monovalent high potency IL-1 beta-binding antibody fragments being highly stable. Such antibodies can be used in the treatment of inflammatory and other diseases as well as in diagnostics. Also provided are related nucleic acids, vectors, cells, and compositions.
    Type: Application
    Filed: August 5, 2022
    Publication date: June 29, 2023
    Applicant: Cell Medica, Inc.
    Inventors: Annemarie HONEGGER, Titus KRETZSCHMAR, Simone SCHMITT, Abdijapar SHAMSHIEV, Stefanie GRABULOVSKI
  • Nucleic acids encoding antibodies against IL-1 beta
    Patent number: 11407824
    Abstract: The present invention relates to anti-IL-1 beta antibodies and in particular to monovalent high potency IL-1 beta-binding antibody fragments being highly stable. Such antibodies can be used in the treatment of inflammatory and other diseases as well as in diagnostics. Also provided are related nucleic acids, vectors, cells, and compositions.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: August 9, 2022
    Assignee: Cell Medica, Inc.
    Inventors: Annemarie Honegger, Titus Kretzschmar, Simone Schmitt, Abdijapar Shamshiev, Stefanie Grabulovski
  • Bispecific HER2 Ligands for Cancer Therapy
    Publication number: 20220135700
    Abstract: The invention relates to a bispecific HER2-targeting agent that includes (a) a first polypeptide ligand that binds to HER2 extracellular domain 1, (b) a second polypeptide ligand that binds to HER2 extracellular domain 4, and (c) a linker covalently attaching said first polypeptide ligand to said second polypeptide ligand.
    Type: Application
    Filed: January 17, 2022
    Publication date: May 5, 2022
    Applicant: UNIVERSITÄT ZÜRICH
    Inventors: Andreas Plückthun, Florian Kast, Martin Schwill, Annemarie Honegger, Rastislav Tamaskovic, Christian Jost
  • HER2-BINDING TETRAMERIC POLYPEPTIDES
    Publication number: 20210395396
    Abstract: The invention relates to a tetrameric polypeptide comprising a first polypeptide chain comprising a first VL antigen binding domain and a first CL constant domain, a second polypeptide chain comprising a first VH antigen binding domain, a first CH1 constant domain, a first CH2 constant domain and a first CH3 constant domain, a first ligand binding to a HER2 D4 epitope linked to the N-terminus of said first VL antigen binding domain or said first VH antigen binding domain by a first interdomain amino acid linker, a third polypeptide chain comprising a second VL antigen binding domain and a second CL constant domain, a fourth polypeptide chain comprising a second VH antigen binding domain, a second CH1 constant domain, a second CH2 constant domain and a second CH3 constant domain and a third ligand binding to a HER2 D4 epitope linked to the N-terminus of said second VL antigen binding domain or said second VH antigen binding domain by a second interdomain amino acid linker, wherein the VL antigen binding domain
    Type: Application
    Filed: October 8, 2019
    Publication date: December 23, 2021
    Applicant: UNIVERSITÄT ZÜRICH
    Inventors: Florian KAST, Martin SCHWILL, Annemarie HONEGGER, Jakob STÜBER, Rastislav TAMASKOVIC, Andreas PLÜCKTHUN
  • ANTIBODIES AGAINST IL-1 BETA
    Publication number: 20200362028
    Abstract: The present invention relates to anti-IL-1 beta antibodies and in particular to monovalent high potency IL-1 beta-binding antibody fragments being highly stable. Such antibodies can be used in the treatment of inflammatory and other diseases as well as in diagnostics. Also provided are related nucleic acids, vectors, cells, and compositions.
    Type: Application
    Filed: February 6, 2020
    Publication date: November 19, 2020
    Inventors: Annemarie Honegger, Titus Kretzschmar, Simone Schmitt, Abdijapar Shamshiev, Stefanie Grabulovski
  • Bispecific HER2 Ligands for Cancer Therapy
    Publication number: 20190127481
    Abstract: The invention relates to a bispecific HER2-targeting agent that includes (a) a first polypeptide ligand that binds to HER2 extracellular domain 1, (b) a second polypeptide ligand that binds to HER2 extracellular domain 4, and (c) a linker covalently attaching said first polypeptide ligand to said second polypeptide ligand.
    Type: Application
    Filed: October 8, 2018
    Publication date: May 2, 2019
    Applicant: UNIVERSITÄT ZÜRICH
    Inventors: Andreas Plückthun, Florian Kast, Martin Schwill, Annemarie Honegger, Rastislav Tamaskovic, Christian Jost
  • ANTIBODIES AGAINST IL-1 BETA
    Publication number: 20180258165
    Abstract: The present invention relates to anti-IL-1 beta antibodies and in particular to monovalent high potency IL-1 beta-binding antibody fragments being highly stable. Such antibodies can be used in the treatment of inflammatory and other diseases as well as in diagnostics. Also provided are related nucleic acids, vectors, cells, and compositions.
    Type: Application
    Filed: February 14, 2018
    Publication date: September 13, 2018
    Inventors: Annemarie Honegger, Titus Kretzschmar, Simone Schmitt, Abdijapar Shamshiev, Stefanie Grabulovski
  • Antibodies against IL-1 beta
    Patent number: 9914772
    Abstract: The present invention relates to anti-IL-1 beta antibodies and in particular to monovalent high potency IL-1 beta-binding antibody fragments being highly stable. Such antibodies can be used in the treatment of inflammatory and other diseases as well as in diagnostics. Also provided are related nucleic acids, vectors, cells, and compositions.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: March 13, 2018
    Assignee: Cell Medica Switzerland AG
    Inventors: Annemarie Honegger, Titus Kretzschmar, Simone Schmitt, Abdijapar Shamshiev, Stefanie Grabulovski
  • ANTIBODIES AGAINST IL-1 BETA
    Publication number: 20160194392
    Abstract: The present invention relates to anti-IL-1 beta antibodies and in particular to monovalent high potency IL-1 beta-binding antibody fragments being highly stable. Such antibodies can be used in the treatment of inflammatory and other diseases as well as in diagnostics. Also provided are related nucleic acids, vectors, cells, and compositions.
    Type: Application
    Filed: June 16, 2015
    Publication date: July 7, 2016
    Inventors: Annemarie Honegger, Titus Kretzschmar, Simone Schmitt, Abdijapar Shamshiev, Stefanie Grabulovski
  • Method for the stabilization of chimeric immunoglobulins or immunoglobulin fragments, and stabilized anti-EGP-2 scFv fragment
    Patent number: 8137932
    Abstract: The present invention relates to a method for stabilizing chimeric immunoglobulins or immunoglobulin fragments. Furthermore, the invention also provides a stabilized anti-EGP-2 scFv fragment.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: March 20, 2012
    Assignee: University of Zurich
    Inventors: Andreas Plückthun, Annemarie Honegger, Jörg Willuda
  • Novel Method for the Stabilization of Chimeric Immunoglobulins or Immunoglobulin Fragments, and Stabilized Anti-EGP-2 SCFV Fragment
    Publication number: 20110136173
    Abstract: The present invention relates to a method for stabilizing chimeric immunoglobulins or immunoglobulin fragments. Furthermore, the invention also provides a stabilized anti-EGP-2 scFv fragment.
    Type: Application
    Filed: December 7, 2010
    Publication date: June 9, 2011
    Inventors: ANDREAS PLÜCKTHUN, ANNEMARIE HONEGGER, JÖRG WILLUDA
  • Method for the stabilization of chimeric immunoglobulins or immunoglobulin fragments, and stabilized anti-EGP-2 scFv fragment
    Patent number: 7858088
    Abstract: The present invention relates to a method for stabilizing chimeric immunoglobulins or immunoglobulin fragments. Furthermore, the invention also provides a stabilized anti-EGP-2 scFv fragment.
    Type: Grant
    Filed: January 3, 2008
    Date of Patent: December 28, 2010
    Assignee: University of Zurich
    Inventors: Andreas Plückthun, Annemarie Honegger, Jörg Willuda
  • NOVEL METHOD FOR THE STABILIZATION OF CHIMERIC IMMUNOGLOBULIN OR IMMUNOGLOBULIN FRAGMENTS AND, AND STABILIZED ANTI-EGP-2 SCFV FRAGMENT
    Publication number: 20080299124
    Abstract: The present invention relates to a method for stabilizing chimeric immunoglobulins or immunoglobulin fragments. Furthermore, the invention also provides a stabilized anti-EGP-2 scFv fragment.
    Type: Application
    Filed: January 3, 2008
    Publication date: December 4, 2008
    Inventors: Andreas Pluckthun, Annemarie Honegger, Jorg Willuda
  • Method for the stabilization of chimeric immunoglobulins or immunoglobulin fragments, and stabilized anti-EGP-2 scFv fragment
    Patent number: 7341722
    Abstract: The present invention relates to a method for stabilizing chimeric immunoglobulins or immunoglobulin fragments. Furthermore, the invention also provides a stabilized anti-EGP-2 scFv fragment.
    Type: Grant
    Filed: December 30, 2004
    Date of Patent: March 11, 2008
    Assignee: University of Zurich
    Inventors: Andreas Pluckthun, Annemarie Honegger, Joerg Willuda
  • Novel method for the stabilization of chimeric immunoglobulins or immunoglobulin fragments, and stabilized anti-EGP-2 scFv fragment
    Publication number: 20060159683
    Abstract: The present invention relates to a method for stabilizing chimeric immunoglobulins or immunoglobulin fragments. Furthermore, the invention also provides a stabilized anti-EGP-2 scFv fragment.
    Type: Application
    Filed: December 30, 2004
    Publication date: July 20, 2006
    Applicant: University of Zurich
    Inventors: Andreas Pluckthun, Annemarie Honegger, Jorg Willuda
  • Modification of human variable domains
    Publication number: 20060127893
    Abstract: The present invention relates to a method for the optimization of isolated human immunoglobulin variable heavy (VH) and light (VL) constructs.
    Type: Application
    Filed: July 19, 2002
    Publication date: June 15, 2006
    Inventors: Stefan Ewert, Thomas Huber, Annemarie Honegger, Andreas Pluckthun
  • Method for the stabilization of chimeric immunoglobulins or immunoglobulin fragments, and stabilized anti-EGP-2 scFv fragment
    Patent number: 7033798
    Abstract: The present invention relates to a method for stabilizing chimeric immunoglobulins or immunoglobulin fragments. Furthermore, the invention also provides a stabilized anti-EGP-2 scFv fragment.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: April 25, 2006
    Assignee: University of Zurich
    Inventors: Andreas Plückthun, Annemarie Honegger, Jörg Willuda
  • Immunoglobulin superfamily domains and fragments with increased solubility
    Patent number: 6815540
    Abstract: The present invention relates to the modification of immunoglobulin superfamily (IgSF) domains, IgSF fragments and fusion proteins thereof, especially to the modification of antibody derivatives, so as to improve their solubility, and hence the yield, and ease of handling. The inventors have found that this can be achieved by making the region which comprised the interface with domains adjoined to said IgSF domain in a larger fragment or a full IgSF protein, and which becomes exposed in the IgSF domain, more hydrophilic by modification. The present invention describes DNA sequences encoding modified IgSF domains or fragments and fusion proteins thereof, vectors and hosts containing these DNA sequences, IgSF domains or fragments or fusion proteins obtainable by expressing said DNA sequences in suitable expression systems, and a method for modifying IgSF domains, so as to improve their solubility, expressibility and ease of handling.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: November 9, 2004
    Assignee: University of Zurich
    Inventors: Andreas Plückthun, Lars Nieba, Annemarie Honegger
  • Novel method for the stabilization of chimeric immunoglobulins or immunoglobulin fragments, and stabilized anti-EGP-2 scFv fragment
    Publication number: 20020146846
    Abstract: The present invention relates to a method for stabilizing chimeric immunoglobulins or immunoglobulin fragments. Furthermore, the invention also provides a stabilized anti-EGP-2 scFv fragment.
    Type: Application
    Filed: October 4, 2001
    Publication date: October 10, 2002
    Inventors: Andreas Pluckthun, Annemarie Honegger, Jorg Willuda