Abstract: For the combinatorial synthesis of molecule libraries, substances are embedded in a matrix consisting of a first solvent thereby forming transport units in a solid state of aggregation at a temperature of less than 90° C. and wherein after application to a support, the physical environment of the transport units is modified by the application of a physical process such as a laser printer whereby the substances in the transport units are linked to the support.

Abstract: The invention relates to a method for the production of a protein library, in particular an antibody library, which is highly diverse and for the selection of proteins, in particular antibodies, therefrom.

Abstract: Disclosed is the use of DMBT1, or of the nucleic acid encoding it, for the manufacture of a medicament for the treatment of a patient suffering from a disease caused by an agent, which possesses at least one accessible sulphate and/or at least one accessible phosphate group, uses of DMBT1 as a diagnostic for diagnosing the susceptibility of an individual to sulphate or phosphate groups, as well as methods for diagnosis, prophylaxis or treatment of diseases caused by an agent which possesses at least one accessible sulphate and/or at least one accessible phosphate group.

Abstract: Provided is a method for monitoring the presence and/or progression of prostate tumor in an individual, by measuring the expression level of marker genes out of a novel signature of 39 genes. The invention further discloses a data base and array comprising said identified marker genes for prognosing the tumor progression in an individual suffering from prostate cancer.

Abstract: Disclosed is the use of DMBT1, or of the nucleic acid encoding it, for the manufacture of a medicament for the treatment of a patient suffering from a disease caused by an agent, which possesses at least one accessible sulphate and/or at least one accessible phosphate group, uses of DMBT1 as a diagnostic for diagnosing the susceptibility of an individual to sulphate or phosphate groups, as well as methods for diagnosis, prophylaxis or treatment of diseases caused by an agent which possesses at least one accessible sulphate and/or at least one accessible phosphate group.

Abstract: The invention relates to a method for the production of a protein library, in particular an antibody library, which is highly diverse and for the selection of proteins, in particular antibodies, therefrom.

Abstract: Incontinentia Pigmenti (IP) is a neurocutaneous genodermatosis that segregates as an X-linked dominant disorder with a high probability of prenatal male lethality. A locus in Xq28 containing NF-&kgr;B Essential Modulator, a gene product involved in the activation of NF-kB and central to many pro-inflammatory and apoptotic pathways, contains mutations in the majority of cases of IP. Disclosed are methods, compositions and kits directed to a defect in a NF-&kgr;B related disease such as IP.

Abstract: For synthesis of a support-bound array of oligomers with free ends A, whereby a temporary protecting group is provided on the 5′-OH end of the oligomers and permanent protecting groups on reactive side groups, it is proposed that the temporary protecting group is removed from the end B after combinatorial synthesis of the oligomers onto the support, the free ends B are then cross-linked even before splitting of the permanent protecting groups, then the covalent bond of the synthesised oligomers can be removed via the end A onto the support, resulting in free ends A, and a portion of the synthesised oligomers binds covalently to the support also after removal of the ends A from the support.

Abstract: Incontinentia Pigmenti (IP) is a neurocutaneous genodermatosis that segregates as an X-linked dominant disorder with a high probability of prenatal male lethality. A locus in Xq28 containing NF-&kgr;B Essential Modulator, a gene product involved in the activation of NF-kB and central to many pro-inflammatory and apoptotic pathways, contains mutations in the majority of cases of IP. Disclosed are methods, compositions and kits directed to a defect in a NF-&kgr;B related disease such as IP.

Abstract: The present invention relates to a method for the preselection of shotgun clones, e.g., cosmids, PACs, BACs, etc. of a genome of an organism, or of parts of the genome of an organism that significantly reduces the time and workload associated with the further processing of shotgun clones, for example, in sequencing projects such as the human genome project. The invention relies on a combination of steps including the transfer of shotgun clones to a carrier. e.g., nylon membrane, glass chip, etc. where the clones bind, preferably hybridize to a set of specifically selected probes, e.g., DNA oligonucleotides, PNA oligonucleotides or pools of DNA or/and PNA oligonucleotides, further antibodies, fragments or derivatives thereof which are labeled or unlabeled. Each probe of said set interacts to 1 to 99% (ideally 50%) of all shotgun clones (nucleic acid fragments) in all investigated shotgun libraries.

Abstract: Described is a nucleic acid molecule comprising (a) a nucleic acid sequence encoding the monocyte-chemoattractant-protein-1 (MCP-1) or a protein having the biological activity of the monocyte-chemoattractant-protein-1 (MCP-1) and (b) a hypersensitivity region. Also described are pharmaceutical compositions for the treatment of diseases associated with dysregulation of MCP-1 expression, e.g. atherosclerosis or cancer.

Abstract: The present invention relates to a protein containing an SRCR domain, a nucleic acid encoding such a protein and a method to produce same. The invention further relates to the use of the nucleic acid and the protein and antibodies directed against the protein.

Abstract: The present invention relates to a method for the preselection of shotgun clones, e.g., cosmids, PACs, BACs, etc. of a genome of an organism, or of parts of the genome of an organism that significantly reduces the time and workload associated with the further processing of shotgun clones, for example, in sequencing projects such as the human genome project. The invention relies on a combination of steps including the transfer of shotgun clones to a carrier, e.g., nylon membrane, glass chip, etc. where the clones bind, preferably hybridize to a set of specifically selected probes, e.g., DNA oligonucleotides, PNA oligonucleotides or pools of DNA or/and PNA oligonucleotides, further antibodies, fragments or derivatives thereof which are labeled or unlabeled.

Abstract: According to the method for detecting optical properties, especially luminescence reactions and refraction behavior of molecules which are directly or indirectly bound on a support, electromagnetic waves, especially laser light, are radiated onto the support. The light that is emitted or refracted by the molecules is then detected by a detector. The detector and the support are moved in relation to each other during and after the radiation of the electromagnetic waves. The support used is especially a transparent support with integrated position markings which can be detected by a detector, especially an optoelectronic scanning system. At least one of the integrated position markings is selected while the support and the detector are being moved in relation to each other or thereafter so that the light that is detected by the detector can be associated with a location on the support.

Abstract: According to the inventive method for applying substances to a support, especially monomers for the combinatorial synthesis of molecule libraries, the substances are first embedded in a matrix consisting of at least one solvent, said solvent being in a solid state of aggregation at a temperature below 90° C., preferably below 50° C. The substances that are embedded in the matrix from transport units which are subsequently applied to the support in a solid state of aggregation, at a temperature below 90° C., preferably below 50° C. Alternatively, the transport units can be dissolved with a second solvent part and applied to the support in a liquid state of aggregation, where they adopt a solid or gel-like stage of aggregation after said solvent part has completely or partially evaporated. The substances on the matrix are then mobilized by modifying their physical environment and brought into the vicinity of the support surface through a physical process.

Abstract: The present invention relates to a tyrosine-phosphatase-related protein, a DNA which codes for such a protein and a process for producing such a protein. In addition, the invention concerns the use of the DNA and protein and antibodies directed against the protein.

Abstract: The present invention relates to a transketolase-related protein, a DNA encoding the same and a process for the preparation thereof. In addition, the invention concerns the use of the DNA and the protein as well as antibodies directed against the protein.