Abstract: The present invention is directed to methods of prognosing, treating, or managing treatment of cancer in a subject. These methods involve selecting a subject having cancer, obtaining, from the selected subject, a sample containing exosomes, recovering the exosomes from the sample, and isolating the double-stranded DNA from within the exosomes. The isolated double-stranded DNA is then used to detect the presence or absence of one or more genetic mutations associated with cancer, quantify the amount of isolated double-stranded DNA from the recovered exosomes in the sample, detect the methylation status of the isolated double-stranded DNA, or quantify the amount isolated double-stranded DNA able to enter a recipient cell. The prognosing, treating, or managing treatment is carried out based on this information.

Abstract: The present invention is directed to methods of prognosing, treating, or managing treatment of cancer in a subject. These methods involve selecting a subject having cancer, obtaining, from the selected subject, a sample containing exosomes, recovering the exosomes from the sample, and isolating the double-stranded DNA from within the exosomes. The isolated double-stranded DNA is then used to detect the presence or absence of one or more genetic mutations associated with cancer, quantify the amount of isolated double-stranded DNA from the recovered exosomes in the sample, detect the methylation status of the isolated double-stranded DNA, or quantify the amount isolated double-stranded DNA able to enter a recipient cell. The prognosing, treating, or managing treatment is carried out based on this information.

Abstract: For monitoring samples to be analyzed, the samples are registered in a client data system and a lab order regarding tests to be performed is generated. A data set of each sample is transmitted to a lab system of a commissioned lab and to a sample monitoring system. Samples assigned to the lab are combined to a batch having a specific batch identification code assigned by the client data system. The data sets of the samples of the batch are correlated to the batch identification code. Collection of the batch by a transport service is recorded in the sample monitoring system, and the transport order is correlated to the batch identification code. The lab acknowledges receipt of the batch to the client data system based on batch identification code or sample data sets. The analytical results linked to the sample data sets are transmitted to the client data system.