Patents by Inventor Annette Grot

Annette Grot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200142127
    Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.
    Type: Application
    Filed: June 3, 2019
    Publication date: May 7, 2020
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Ravi SAXENA, Michael Tzu RU, Takashi Whitney ORIMOTO, Annette GROT, Mathieu FOQUET, Hou-Pu CHOU
  • Patent number: 10626457
    Abstract: Arrays of integrated optical devices and their methods for production are provided. The devices include an integrated bandpass filter layer that comprises at least two multi-cavity filter elements with different central bandpass wavelengths. The device arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices provide for the efficient and reliable coupling of optical excitation energy from an optical source to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination. The device arrays are well suited for miniaturization and high throughput.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: April 21, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Ravi Saxena, Annette Grot, Nicolaas Tack, Pilar Gonzalez, Bert Du Bois, Simone Severi
  • Patent number: 10578788
    Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. In some embodiments, the devices comprise an optical waveguide comprising a plurality of optical cores and a cladding, a plurality of nanometer-scale apertures disposed on a surface of the device above the optical waveguide, such that optical energy passing through the plurality of optical cores of the optical waveguide illuminates the plurality of nanometer-scale apertures by an evanescent field that emanates from the waveguide, and a plurality of detectors optically coupled to the plurality of nanometer-scale apertures. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: March 3, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Annette Grot, Shang Wang, Hans Callebaut, Paul Lundquist, Stephen Turner
  • Publication number: 20200018703
    Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
    Type: Application
    Filed: March 14, 2019
    Publication date: January 16, 2020
    Inventors: Annette GROT, Ravi SAXENA, Paul LUNDQUIST
  • Patent number: 10310178
    Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: June 4, 2019
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Ravi Saxena, Michael Tzu Ru, Takashi Whitney Orimoto, Annette Grot, Mathieu Foquet, Hou-Pu Chou
  • Patent number: 10234393
    Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: March 19, 2019
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Annette Grot, Ravi Saxena, Paul Lundquist
  • Publication number: 20190064421
    Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.
    Type: Application
    Filed: July 9, 2018
    Publication date: February 28, 2019
    Inventors: Annette GROT, Shang WANG, Hans CALLEBAUT, Paul LUNDQUIST, Stephen TURNER
  • Publication number: 20180239087
    Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.
    Type: Application
    Filed: April 16, 2018
    Publication date: August 23, 2018
    Inventors: Ravi SAXENA, Michael Tzu RU, Takashi Whitney ORIMOTO, Annette GROT, Mathieu FOQUET, Hou-Pu CHOU
  • Patent number: 10018764
    Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: July 10, 2018
    Assignee: Pacific Biosciences of California
    Inventors: Annette Grot, Shang Wang, Hans Callebaut, Paul Lundquist, Stephen Turner
  • Publication number: 20180180548
    Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
    Type: Application
    Filed: February 20, 2018
    Publication date: June 28, 2018
    Inventors: Annette GROT, Ravi SAXENA, Paul LUNDQUIST
  • Patent number: 9946017
    Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: April 17, 2018
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Ravi Saxena, Michael Tzu Ru, Takashi Whitney Orimoto, Annette Grot, Mathieu Foquet, Hou-Pu Chou
  • Patent number: 9915612
    Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: March 13, 2018
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Annette Grot, Ravi Saxena, Paul Lundquist
  • Publication number: 20170322156
    Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.
    Type: Application
    Filed: May 19, 2017
    Publication date: November 9, 2017
    Inventors: Ravi SAXENA, Michael Tzu RU, Takashi Whitney ORIMOTO, Annette GROT, Mathieu FOQUET, Hou-Pu CHOU
  • Publication number: 20170176335
    Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
    Type: Application
    Filed: March 6, 2017
    Publication date: June 22, 2017
    Inventors: Annette GROT, Ravi SAXENA, Paul LUNDQUIST
  • Publication number: 20170145498
    Abstract: Arrays of integrated optical devices and their methods for production are provided. The devices include an integrated bandpass filter layer that comprises at least two multi-cavity filter elements with different central bandpass wavelengths. The device arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices provide for the efficient and reliable coupling of optical excitation energy from an optical source to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination. The device arrays are well suited for miniaturization and high throughput.
    Type: Application
    Filed: October 28, 2016
    Publication date: May 25, 2017
    Inventors: Ravi SAXENA, Annette GROT, Nicolaas TACK, Pilar GONZALEZ, Bert DU BOIS, Simone SEVERI
  • Patent number: 9658161
    Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: May 23, 2017
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Ravi Saxena, Michael Tzu Ru, Takashi Whitney Orimoto, Annette Grot, Mathieu Foquet, Hou-Pu Chou
  • Patent number: 9606068
    Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: March 28, 2017
    Assignee: PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
    Inventors: Annette Grot, Ravi Saxena, Paul Lundquist
  • Publication number: 20160334334
    Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.
    Type: Application
    Filed: May 19, 2016
    Publication date: November 17, 2016
    Inventors: Ravi SAXENA, Michael Tzu RU, Takashi Whitney ORIMOTO, Annette GROT, Mathieu FOQUET, Hou-Pu CHOU
  • Patent number: 9372308
    Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.
    Type: Grant
    Filed: June 17, 2013
    Date of Patent: June 21, 2016
    Assignee: PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
    Inventors: Ravi Saxena, Michael Tzu Ru, Takashi Whitney Orimoto, Annette Grot, Mathieu Foquet, Hou-Pu Chou
  • Patent number: 9366814
    Abstract: The application relates to methods of manufacture of improved optical containment structures. The invention relates to arrays of zero-mode waveguide structures comprising nanoscale apertures having non-reflective coatings on their walls. The methods provide for selectively coating the walls of the zero mode waveguides, allowing for selective functionalization of the bases.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: June 14, 2016
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Jeremy Gray, Ronald L. Cicero, Annette Grot