Patents by Inventor Annette Grot
Annette Grot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230417975Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.Type: ApplicationFiled: May 1, 2023Publication date: December 28, 2023Applicant: Pacific Biosciences of California, Inc.Inventors: Annette GROT, Shang WANG, Hans CALLEBAUT, Paul LUNDQUIST, Stephen TURNER
-
Publication number: 20230314325Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.Type: ApplicationFiled: October 10, 2022Publication date: October 5, 2023Applicant: Pacific Biosciences of California, Inc.Inventors: Annette GROT, Ravi SAXENA, Paul LUNDQUIST
-
Patent number: 11640022Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.Type: GrantFiled: October 4, 2021Date of Patent: May 2, 2023Assignee: Pacific Biosciences of California, Inc.Inventors: Annette Grot, Shang Wang, Hans Callebaut, Paul Lundquist, Stephen Turner
-
Publication number: 20230035224Abstract: Arrays of integrated analytical devices are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. In particular, the arrays provide increased efficiency of optical collection and decreased background signal as the lateral dimensions of the unit cell of devices within the array are decreased, for example as they are decreased to 2 ?m, or even less.Type: ApplicationFiled: May 4, 2022Publication date: February 2, 2023Inventors: Hans CALLEBAUT, Mark MCDONALD, Arghavan ARJMAND, Annette GROT, Mathieu FOQUET, Ravi SAXENA, Michael Tzu RU
-
Patent number: 11467089Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.Type: GrantFiled: December 7, 2020Date of Patent: October 11, 2022Assignee: Pacific Biosciences of California, Inc.Inventors: Annette Grot, Ravi Saxena, Paul Lundquist
-
Publication number: 20220171114Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.Type: ApplicationFiled: October 4, 2021Publication date: June 2, 2022Inventors: Annette GROT, Shang WANG, Hans CALLEBAUT, Paul LUNDQUIST, Stephen TURNER
-
Patent number: 11272132Abstract: Provided are pixels, devices, systems, and methods relating to active pixel sensor in which each active pixel puts out a signal that represents a temporal differential. The output of the active pixel represents a comparison or difference between successive frames. The differential can represent the state of the sensor element in the pixel at the end of one frame compared to the state of the sensor element of the frame, at the end of the prior frame.Type: GrantFiled: June 5, 2020Date of Patent: March 8, 2022Assignee: Pacific Biosciences of California, Inc.Inventors: Annette Grot, Stephen Turner, Steven Benjamin Warren
-
Publication number: 20210325306Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.Type: ApplicationFiled: December 7, 2020Publication date: October 21, 2021Applicant: Pacific Biosciences of California, Inc.Inventors: Annette GROT, Ravi SAXENA, Paul LUNDQUIST
-
Patent number: 11137532Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.Type: GrantFiled: March 1, 2020Date of Patent: October 5, 2021Assignee: Pacific Biosciences of California, Inc.Inventors: Annette Grot, Shang Wang, Hans Callebaut, Paul Lundquist, Stephen Turner
-
Publication number: 20210285881Abstract: Provided herein are highly multiplexed optical analytical systems for improved nucleic acid sequencing. The systems include a plurality of highly multiplexed optical chips, at least one optical source, and a plurality of optical delivery devices for illuminating an array of nanoscale rection regions on each of the optical chips. In use, the reaction regions contain fluorescent nucleic acid sequencing reagents and are arranged to report nucleic acid sequence information to optical detectors associated with the multiplexed optical chips in real time. The systems enable a massive increase in the scale of nucleic acid sequencing reactions capable of being performed within a single instrument without a corresponding increase in size, complexity, or cost of the instrument.Type: ApplicationFiled: February 18, 2021Publication date: September 16, 2021Inventors: Alexey KURITSYN, Mark MCDONALD, Aaron RULISON, Annette GROT
-
Publication number: 20210124115Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.Type: ApplicationFiled: September 4, 2020Publication date: April 29, 2021Applicant: Pacific Biosciences of California, Inc.Inventors: Ravi SAXENA, Michael Tzu RU, Takashi Whitney ORIMOTO, Annette GROT, Mathieu FOQUET, Hou-Pu CHOU
-
Publication number: 20200389616Abstract: Provided are pixels, devices, systems, and methods relating to active pixel sensor in which each active pixel puts out a signal that represents a temporal differential. The output of the active pixel represents a comparison or difference between successive frames. The differential can represent the state of the sensor element in the pixel at the end of one frame compared to the state of the sensor element of the frame, at the end of the prior frame.Type: ApplicationFiled: June 5, 2020Publication date: December 10, 2020Inventors: Annette Grot, Stephen Turner, Steven Benjamin Warren
-
Patent number: 10859497Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.Type: GrantFiled: March 14, 2019Date of Patent: December 8, 2020Assignee: Pacific Biosciences of California, Inc.Inventors: Annette Grot, Ravi Saxena, Paul Lundquist
-
Publication number: 20200341181Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.Type: ApplicationFiled: March 1, 2020Publication date: October 29, 2020Inventors: Annette GROT, Shang WANG, Hans CALLEBAUT, Paul LUNDQUIST, Stephen TURNER
-
Patent number: 10768362Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.Type: GrantFiled: June 3, 2019Date of Patent: September 8, 2020Assignee: Pacific Biosciences of California, Inc.Inventors: Ravi Saxena, Michael Tzu Ru, Takashi Whitney Orimoto, Annette Grot, Mathieu Foquet, Hou-Pu Chou
-
Publication number: 20200142127Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.Type: ApplicationFiled: June 3, 2019Publication date: May 7, 2020Applicant: Pacific Biosciences of California, Inc.Inventors: Ravi SAXENA, Michael Tzu RU, Takashi Whitney ORIMOTO, Annette GROT, Mathieu FOQUET, Hou-Pu CHOU
-
Patent number: 10626457Abstract: Arrays of integrated optical devices and their methods for production are provided. The devices include an integrated bandpass filter layer that comprises at least two multi-cavity filter elements with different central bandpass wavelengths. The device arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices provide for the efficient and reliable coupling of optical excitation energy from an optical source to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination. The device arrays are well suited for miniaturization and high throughput.Type: GrantFiled: October 28, 2016Date of Patent: April 21, 2020Assignee: Pacific Biosciences of California, Inc.Inventors: Ravi Saxena, Annette Grot, Nicolaas Tack, Pilar Gonzalez, Bert Du Bois, Simone Severi
-
Patent number: 10578788Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. In some embodiments, the devices comprise an optical waveguide comprising a plurality of optical cores and a cladding, a plurality of nanometer-scale apertures disposed on a surface of the device above the optical waveguide, such that optical energy passing through the plurality of optical cores of the optical waveguide illuminates the plurality of nanometer-scale apertures by an evanescent field that emanates from the waveguide, and a plurality of detectors optically coupled to the plurality of nanometer-scale apertures. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions.Type: GrantFiled: July 9, 2018Date of Patent: March 3, 2020Assignee: Pacific Biosciences of California, Inc.Inventors: Annette Grot, Shang Wang, Hans Callebaut, Paul Lundquist, Stephen Turner
-
Publication number: 20200018703Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.Type: ApplicationFiled: March 14, 2019Publication date: January 16, 2020Inventors: Annette GROT, Ravi SAXENA, Paul LUNDQUIST
-
Patent number: 10310178Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.Type: GrantFiled: April 16, 2018Date of Patent: June 4, 2019Assignee: Pacific Biosciences of California, Inc.Inventors: Ravi Saxena, Michael Tzu Ru, Takashi Whitney Orimoto, Annette Grot, Mathieu Foquet, Hou-Pu Chou