Abstract: A detection device for detecting contamination of an optical element. The detection device includes a coupling device, including a first coupling element for coupling light of at least one wavelength from a light source into the optical element, and a second coupling element for coupling light out from the optical element, at least one of the coupling elements including a hologram, and having a detector for acquiring the coupled-out light.

Abstract: The present inventions relates to substances which are capable of controlling the inclusion of exon (10) of the tau gene. The substances can reverse “wrong” tau splicing pattern and. Since “wrong” tau splicing patterns are associated with tauopathies that cause dementia, the substances can be used as therapeutic agents. The invention also provides a method for testing substances that control tau exon (10) inclusion. The method is suitable for a high throughput screening. Additional products which are useful for changing tau exon (10) expression or for performing the test method are described as well.