Patents by Inventor Annette Kim

Annette Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tyrosine kinase inhibitors
    Patent number: 7348431
    Abstract: The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a benzazocine moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: March 25, 2008
    Assignee: Merck & Co., Inc.
    Inventor: Annette Kim
  • Tyrosine kinase inhibitors
    Publication number: 20070173525
    Abstract: The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a benzazocine moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
    Type: Application
    Filed: April 2, 2007
    Publication date: July 26, 2007
    Inventors: Annette Kim, Craig Stump, Christopher Dinsmore, Samuel Graham, Theresa Williams, Diem Nguyen, B. Trotter
  • Tyrosine kinase inhibitors
    Publication number: 20060276514
    Abstract: The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a substituted pyrrole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
    Type: Application
    Filed: July 20, 2004
    Publication date: December 7, 2006
    Inventor: Annette Kim
  • Tyrosine kinase inhibitors
    Publication number: 20060189577
    Abstract: The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a substituted pyrrole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
    Type: Application
    Filed: July 20, 2004
    Publication date: August 24, 2006
    Inventors: Annette Kim, Xufang Zhang
  • Tyrosine kinase inhibitors
    Publication number: 20060167036
    Abstract: The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a benzazocine moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
    Type: Application
    Filed: April 8, 2003
    Publication date: July 27, 2006
    Inventor: Annette Kim
  • Tyrosine kinase inhibitors
    Publication number: 20050239815
    Abstract: The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a benzazocine moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
    Type: Application
    Filed: April 8, 2003
    Publication date: October 27, 2005
    Inventors: Annette Kim, Craig Stump, Christopher Dinsmore, Samuel Graham, Theresa Williams, Diem Nguyen, B. Wesley Trotter
  • Synthetic lethal screen using RNA interference
    Publication number: 20050181385
    Abstract: The invention provides a method for identifying one or more genes in a cell of a cell type which interact with, e.g., modulate the effect of, an agent, e.g., a drug. For example, an identified gene may confer resistance or sensitivity to a drug, i.e., reduces or enhances the effect of the drug. The invention also provides STK6 and TPX2 as a gene that exhibits synthetic lethal interactions with KSP encoding a kinesin-like motor protein, and methods and compositions for treatment of diseases, e.g., cancers, by modulating the expression of STK6 or TPX2 gene and/or the activity of STK6 or TPX2 gene product. The invention also provides genes involved in cellular response to DNA damage, and their therapeutic uses.
    Type: Application
    Filed: September 22, 2004
    Publication date: August 18, 2005
    Inventors: Peter Linsley, Mao Mao, Annette Kim, Stephen Friend, Steven Bartz, Michele Cleary