Patents by Inventor Annette M. Shadiack

Annette M. Shadiack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Melanocortin receptor-specific compounds
    Patent number: 7964601
    Abstract: A melanocortin receptor-specific compound of the general formula of structure I: where X, R1, R2a, R2b, R3, R4a, R4b, R5a and R5b are as defined in the specification, which compound binds with high affinity to one or more melanocortin receptors and is optionally an agonist, an antagonist, an inverse agonist or an antagonist of an inverse agonist, and may be employed for treatment of one or melanocortin receptor-associated conditions or disorders, and methods for the use of the compounds of the invention.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: June 21, 2011
    Assignee: Palatin Technologies, Inc.
    Inventors: Shubh D. Sharma, Yi-Qun Shi, Ramesh Rajpurohit, Zhijun Wu, Papireddy Purma, Annette M. Shadiack, Kevin D. Burris
  • Peptide compositions for treatment of sexual dysfunction
    Patent number: 7795378
    Abstract: A peptide of the structural formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, m and n are as defined. Further provided are methods for treatment of sexual dysfunction, including erectile dysfunction and female sexual dysfunction, and combination drugs and method of use thereof, including a peptide of the invention and one or more second sexual dysfunction pharmaceutical agents.
    Type: Grant
    Filed: January 7, 2005
    Date of Patent: September 14, 2010
    Assignee: Palatin Technologies, Inc.
    Inventors: Shubh D. Sharma, Annette M. Shadiack, Ramesh Rajpurohit, Wei Yang
  • Naphthalene-containing melanocortin receptor-specific small molecule
    Patent number: 7732451
    Abstract: A method of modulating energy homeostasis in a mammal without eliciting a sexual response by administration of a therapeutically effective amount of a pharmaceutical composition including a melanocortin receptor compound of the formula: where R1 is a bond or a linker unit including from one to six backbone atoms and an unsubstituted naphthalene group, and L, R2, R3 and Rx are as defined in the specification.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: June 8, 2010
    Assignee: Palatin Technologies, Inc.
    Inventors: Shubh D. Sharma, Annette M. Shadiack, Yiqun Shi, Zhijun Wu, Ramesh Rajpurohit, Kevin D. Burris, Papireddy Purma
  • Melanocortin receptor-specific compounds
    Patent number: 7456184
    Abstract: A melanocortin receptor-specific compound of the general formula of structure I: where X, R1, R2a, R2b, R3, R4a, R4b, R5a and R5b are as defined in the specification, which compound binds with high affinity to one or more melanocortin receptors and is optionally an agonist, an antagonist, an inverse agonist or an antagonist of an inverse agonist, and may be employed for treatment of one or melanocortin receptor-associated conditions or disorders, and methods for the use of the compounds of the invention.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: November 25, 2008
    Assignee: Palatin Technologies Inc.
    Inventors: Shubh D. Sharma, Yi-Qun Shi, Zhijun Wu, Ramesh Rajpurohit, Annette M. Shadiack, Papireddy Purma, Kevin D. Burris
  • Melanocortin Receptor-Specific Compounds
    Publication number: 20080234289
    Abstract: A melanocortin receptor-specific compound of the general formula of structure I: where X, R1, R2a, R2b, R3, R4a, R4b, R5a and R5b are as defined in the specification, which compound binds with high affinity to one or more melanocortin receptors and is optionally an agonist, an antagonist, an inverse agonist or an antagonist of an inverse agonist, and may be employed for treatment of one or melanocortin receptor-associated conditions or disorders, and methods for the use of the compounds of the invention.
    Type: Application
    Filed: June 2, 2008
    Publication date: September 25, 2008
    Applicant: Palatin Technologies, Inc.
    Inventors: Shubh D. Sharma, Yi-Qun Shi, Ramesh Rajpurohit, Zhijun Wu, Papireddy Purma, Annette M. Shadiack, Kevin D. Burris
  • Linear and cyclic melanocortin receptor-specific peptides
    Patent number: 7417027
    Abstract: Linear and cyclic peptides are provided specific to one or melanocortin receptors, and which exhibit agonist, antagonist, or mixed agonist-antagonist activity.
    Type: Grant
    Filed: January 12, 2004
    Date of Patent: August 26, 2008
    Assignee: Palatin Technologies, Inc.
    Inventors: Shubh D. Sharma, Annette M. Shadiack, Wei Yang, Ramesh Rajpurohit
  • Metallopeptide compositions for treatment of sexual dysfunction
    Patent number: 7396814
    Abstract: Metallopeptide compositions are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. The metallopeptides include at least one, and preferably two, aromatic amino acid side chain moieties, and are further characterized in that the metallopeptides preferably do not bind or significantly bind to a melanocortin receptor.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: July 8, 2008
    Assignee: Palatin Technologies, Inc.
    Inventors: Shubh D. Sharma, Annette M. Shadiack, Wei Yang, Ramesh Rajpurohit
  • Cyclic peptides for treatment of cachexia
    Patent number: 7345144
    Abstract: A highly selective melanocortin-4 receptor antagonist cyclic hexapeptide of the formula where R1, R2, R3a, R3b, R4, R5, x, y and z are as defined in the specification, and a method of treating body weight disorders, including cachexia, sarcopenia and wasting syndrome or disease, and treating inflammation and immune disorders.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: March 18, 2008
    Assignee: Palatin Technologies, Inc.
    Inventors: Shubh D. Sharma, Ramesh Rajpurohit, Annette M. Shadiack, Yi-Qun Shi, Kevin D. Burris
  • Cyclic peptides for treatment for cachexia
    Patent number: 7342089
    Abstract: A highly selective melanocortin-4 receptor antagonist cyclic peptide of the formula where R1, R2, R3, R4a, R4b, R5, R6, R7, x, y and z are as defined in the specification, and a method of treating body weight disorders, including cachexia, sarcopenia and wasting syndrome or disease, and treating inflammation and immune disorders.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: March 11, 2008
    Assignee: Palatin Technologies, Inc.
    Inventors: Shubh D. Sharma, Ramesh Rajpurohit, Annette M. Shadiack, Yi-Qun Shi, Kevin D. Burris
  • Multiple agent therapy for sexual dysfunction
    Patent number: 7235625
    Abstract: Multiple agent therapy for treatment of sexual dysfunction, including male erectile dysfunction, with sequential administration a type V phosphodiesterase inhibitor (PDE-5), such as sildenafil, preferably wherein the PDE-5 inhibitor is administered by oral dose means, and a melanocortin 3 and/or 4 receptor agonist, such as Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH (PT-141) preferably wherein the PT-141 is formulated for and administered by intranasal means, and further preferably wherein the PDE-5 inhibitor is administered prior to PT-141.
    Type: Grant
    Filed: May 26, 2005
    Date of Patent: June 26, 2007
    Assignee: Palatin Technologies, Inc.
    Inventors: Lisa E. Diamond, Dennis C. Earle, Annette M. Shadiack, Shubh D. Sharma, Carl Spana
  • Melanocortin receptor-specific compounds
    Publication number: 20040224957
    Abstract: A melanocortin receptor-specific compound of the general formula of structure I: 1
    Type: Application
    Filed: April 30, 2004
    Publication date: November 11, 2004
    Applicant: Palatin Technologies, Inc.
    Inventors: Shubh D. Sharma, Yi-Qun Shi, Ramesh Rajpurohit, Zhijun Wu, Papireddy Purma, Annette M. Shadiack, Kevin D. Burris
  • Compositions and methods for treatment of sexual dysfunction
    Patent number: 6794489
    Abstract: Compositions and methods are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. In one embodiment, a peptide-based composition including the peptide sequence Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH is administered. Methods of administration include injection, oral, nasal and mucosal administration.
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: September 21, 2004
    Assignee: Palatin Technologies, Inc.
    Inventors: Christine H. Blood, Annette M. Shadiack, Joanna K. Bernstein, Guy H. Herbert
  • Cyclic peptide compositions and methods for treatment of sexual dysfunction
    Publication number: 20040138136
    Abstract: A cyclic peptide of the structural formula: 1
    Type: Application
    Filed: August 8, 2003
    Publication date: July 15, 2004
    Inventors: Shubh D. Sharma, Annette M. Shadiack, Ramesh Rajpurohit, Wei Yang
  • Melanocortin metallopeptides for treatment of sexual dysfunction
    Publication number: 20040038897
    Abstract: Metallopeptides are provided for use in treatment of sexual dysfunction in mammals. The metallopeptides are agonists for at least one of melanocortin-3 or melanocortin-4 receptors. The metallopeptides are conformationally fixed on complexation of a metal ion-binding portion thereof with a metal ion. Also provided are metallopeptides that are antagonists for at least one of melanocortin-3 or melanocortin-4 receptors.
    Type: Application
    Filed: August 13, 2003
    Publication date: February 26, 2004
    Inventors: Shubh D. Sharma, Annette M. Shadiack, Yi-Qun Shi, Wei Yang, Hui-Zhi Cai
  • Compositions and methods for treatment of sexual dysfunction
    Patent number: 6579968
    Abstract: Compositions and methods are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. In one embodiment, a peptide-based composition including the peptide sequence Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH is administered. Methods of administration include injection, oral, nasal and mucosal administration.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: June 17, 2003
    Assignee: Palatin Technologies, Inc.
    Inventors: Christine H. Blood, Annette M. Shadiack, Joanna K. Bernstein, Guy H. Herbert
  • Compositions and methods for treatment of sexual dysfunction
    Publication number: 20020107182
    Abstract: Compositions and methods are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. In one embodiment, a peptide-based composition including the peptide sequence Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH is administered. Methods of administration include injection, oral, nasal and mucosal administration.
    Type: Application
    Filed: January 4, 2002
    Publication date: August 8, 2002
    Inventors: Christine H. Blood, Annette M. Shadiack, Joanna K. Bernstein, Guy H. Herbert