Patents by Inventor Annibale Alessandro PUCA

Annibale Alessandro PUCA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variant of a BPIFB4 protein
    Patent number: 11891421
    Abstract: The present invention relates to a variant of BPIFB4 protein (Bactericidal/Permeability Increasing protein family B, member 4) and to a polynucleotide or a vector encoding said variant of BPIFB4 protein and to their use for the treatment of pathologies involving impairment of nitric oxide signalling.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: February 6, 2024
    Assignee: LGVI S.R.L.
    Inventors: Annibale Alessandro Puca, Carmine Vecchione
  • VARIANT OF A BPIFB4 PROTEIN
    Publication number: 20220169686
    Abstract: The present invention relates to a variant of BPIFB4 protein (Bactericidal/Permeability Increasing protein family B, member 4) and to a polynucleotide or a vector encoding said variant of BPIFB4 protein and to their use for the treatment of pathologies involving impairment of nitric oxide signalling.
    Type: Application
    Filed: November 12, 2021
    Publication date: June 2, 2022
    Inventors: Annibale Alessandro PUCA, Carmine Vecchione
  • Viral vector suitable for gene therapy encoding a variant of a BPIFB4 protein
    Patent number: 11208447
    Abstract: The present invention relates inter alia to a polynucleotide or viral vector encoding a variant of BPIFB4 (Bactericidal/Permeability Increasing protein family B, member 4) protein and to their use for the treatment of pathologies involving impairment of nitric oxide signalling.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: December 28, 2021
    Assignee: ROXIANT APS
    Inventors: Annibale Alessandro Puca, Carmine Vecchione
  • VTFT ISOFORM OF A BPIFB4 PROTEIN FOR USE IN NEURONAL DISEASES AND INJURIES
    Publication number: 20210128681
    Abstract: The invention relates inter alia to a protein which is a VTFT isoform of a BPIFB4 protein or a functional fragment thereof for use in the treatment or prophylaxis of a condition selected from neuronal diseases and injuries, said diseases and injuries being associated with mitochondrial dysfunction and/or protein aggregation and/or ameliorated by CXCR4 activation.
    Type: Application
    Filed: August 16, 2018
    Publication date: May 6, 2021
    Inventor: Annibale Alessandro Puca
  • VIRAL VECTOR SUITABLE FOR GENE THERAPY ENCODING A VARIANT OF A BPIFB4 PROTEIN
    Publication number: 20210017244
    Abstract: The present invention relates inter alia to a polynucleotide or viral vector encoding a variant of BPIFB4 (Bactericidal/Permeability Increasing protein family B, member 4) protein and to their use for the treatment of pathologies involving impairment of nitric oxide signalling.
    Type: Application
    Filed: July 15, 2019
    Publication date: January 21, 2021
    Inventors: Annibale Alessandro Puca, Carmine Vecchione
  • VARIANT OF BPIFB4 PROTEIN
    Publication number: 20150344536
    Abstract: The present invention relates to a variant of BPIFB4 (Bactericidal/Permeability Increasing protein family B, member 4) protein and to its use for the treatment of pathologies involving impairment of nitric oxide signalling.
    Type: Application
    Filed: December 27, 2013
    Publication date: December 3, 2015
    Inventors: Annibale Alessandro PUCA, Carmine CHIONE