Patents by Inventor Annibale Salvi

Annibale Salvi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of r(+) alpha-lipoic acid
    Publication number: 20030187279
    Abstract: Process for the synthesis of R(+)&agr;-lipoic acid comprising the following stages: a) Salifying of racemic thioctic acid with R(+)&agr;-methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt of R(+)&agr;-lipoic acid-R(+)&agr;-methylbenzylamine; c) purification by re-crystallization of the diastereoisomeric salt of R(+)&agr;-lipoic acid-R(+)&agr;-methylbenzylamine, in which the re-crystallization solvent consists of a mixture of non-polar/polar solvents; d) separation of the diastereoisomeric salt to obtain R(+)&agr;-lipoic acid by reaction of said salt with acids selected from the group consisting of aliphatic hydroxy-carboxylic acids having 3 to 6 carbon atoms and aqueous phosphoric acid.
    Type: Application
    Filed: April 9, 2003
    Publication date: October 2, 2003
    Inventors: Flavio Villani, Antonio Nardi, Annibale Salvi, Giovanna Falabella